邓菲

姓       名：邓菲

职称职务：研究员/国家病毒资源库主任

电子邮箱：df@wh.iov.cn

研究方向

1.（蜱传）新病毒资源的发现、收集、保藏

2.蜱传病毒病原学、流行病学调查研究

3.蜱传病毒传播、感染、致病机制研究

4.蜱传病毒抗病毒药物筛选评价与新型疫苗研制

5.以病毒为载体的新型生物技术的研发

教育及工作经历

1994.09-1998.07    华东理工大学                           生物工程        学士

1998.09-2003.07    中国科学院水生生物研究所       遗传学           博士

2003.07-2007.08    中国科学院武汉病毒研究所       助理研究员

2007.09-2013.08    中国科学院武汉病毒研究所       副研究员

2013.09-至今           中国科学院武汉病毒研究所       研究员

近五年承担项目

主持和承担国家重点研发计划、科技部基础性工作专项、国家科技资源服务共享平台项目、中国科学院战略生物资源能力建设项目、中国科学院战略先导科技专项、中科院应急公关专项、湖北省卫健委创新团体项目等多项国家级、省级科研及平台建设项目。

近五年代表性论文

发表论文

1.Mo Q, Xu Z, Deng F, Wang H, Ning YJ. Host restriction of emerging high-pathogenic bunyaviruses via MOV10 by targeting viral nucleoprotein and blocking ribonucleoprotein assembly. PLoS Pathog. 2020 Dec 7;16(12):e1009129. doi: 10.1371/journal.ppat.1009129. PMID: 33284835; PMCID: PMC7746268.

2.Min YQ, Mo Q, Wang J, Deng F, Wang H, Ning YJ. SARS-CoV-2 nsp1: Bioinformatics, Potential Structural and Functional Features, and Implications for Drug/Vaccine Designs. Front Microbiol. 2020 Sep 29;11:587317. doi: 10.3389/fmicb.2020.587317. PMID: 33133055; PMCID: PMC7550470.

3.Yuan C, Wu J, Peng Y, Li Y, Shen S, Deng F, Hu Z, Zhou J, Wang M, Zou Z. Transcriptome analysis of the innate immune system of Hyalomma asiaticum. J Invertebr Pathol. 2020 Nov;177:107481. doi: 10.1016/j.jip.2020.107481. Epub 2020 Oct 6. PMID: 33035534.

4.Zhang ZR, Zhang YN, Li XD, Zhang HQ, Xiao SQ, Deng F, Yuan ZM, Ye HQ, Zhang B. A cell-based large-scale screening of natural compounds for inhibitors of SARS-CoV-2. Signal Transduct Target Ther. 2020 Oct 3;5(1):218. doi: 10.1038/s41392-020-00343-z. PMID: 33011739; PMCID: PMC7532339.

5.Wu X, Li M, Zhang Y, Liang B, Shi J, Fang Y, Su Z, Li M, Zhang W, Xu L, Wang J, Wu Q, Tang S, Wang H, Zhang T, Peng C, Zheng X, Deng F, Shen S. Novel SFTSV Phylogeny Reveals New Reassortment Events and Migration Routes. Virol Sin. 2020 Sep 22. doi: 10.1007/s12250-020-00289-0. Epub ahead of print. PMID: 32960400.

6.Mu J, Fang Y, Yang Q, Shu T, Wang A, Huang M, Jin L, Deng F, Qiu Y, Zhou X. SARS-CoV-2 N protein antagonizes type I interferon signaling by suppressing phosphorylation and nuclear translocation of STAT1 and STAT2. Cell Discov. 2020 Sep 15;6:65. doi: 10.1038/s41421-020-00208-3. PMID: 32953130; PMCID: PMC7490572.

7.Zhang L, Liu J, Cao R, Xu M, Wu Y, Shang W, Wang X, Zhang H, Jiang X, Sun Y, Hu H, Li Y, Zou G, Zhang M, Zhao L, Li W, Guo X, Zhuang X, Yang XL, Shi ZL, Deng F, Hu Z, Xiao G, Wang M, Zhong W. Comparative Antiviral Efficacy of Viral Protease Inhibitors against the Novel SARS-CoV-2 In Vitro. Virol Sin. 2020 Sep 10:1–9. doi: 10.1007/s12250-020-00288-1. Epub ahead of print. PMID: 32910347; PMCID: PMC7481761.

8.Tu D, Shu J, Wu X, Li H, Xia Z, Zhang Y, Fang Y, Shen S, Guan W, Wang H, Huang Z, Wang G, Zhou X, Deng F. Immunological detection of serum antibodies in pediatric medical workers exposed to varying levels of SARS-CoV-2. J Infect. 2020 Jul 25:S0163-4453(20)30504-1. doi: 10.1016/j.jinf.2020.07.023. Epub ahead of print. PMID: 32721505; PMCID: PMC7382336.

9.Zohaib A, Zhang J, Saqib M, Athar MA, Hussain MH, Chen J, Sial AU, Tayyab MH, Batool M, Khan S, Luo Y, Waruhiu C, Taj Z, Hayder Z, Ahmed R, Siddique AB, Yang X, Qureshi MA, Ujjan IU, Lail A, Khan I; Sajjad-Ur-Rahman, Zhang T, Deng F, Shi Z, Shen S. Serologic Evidence of Severe Fever with Thrombocytopenia Syndrome Virus and Related Viruses in Pakistan. Emerg Infect Dis. 2020 Jul;26(7):1513-1516. doi: 10.3201/eid2607.190611. PMID: 32568060; PMCID: PMC7323538.

10.Wang J, Liu X, Zhu Q, Wu Q, Tang S, Zhang L, Fan Z, Hu Z, Wang H, Deng F, Shen S. Identification, Isolation, and Characterization of an Ectromelia Virus New Strain from an Experimental Mouse. Virol Sin. 2020 Jul 21. doi: 10.1007/s12250-020-00263-w. Epub ahead of print. PMID: 32696398.

11.Zheng X, Wang H, Su Z, Li W, Yang D, Deng F, Chen J. Co-infection of SARS-CoV-2 and Influenza virus in Early Stage of the COVID-19 Epidemic in Wuhan, China. J Infect. 2020 Aug;81(2):e128-e129. doi: 10.1016/j.jinf.2020.05.041. Epub 2020 May 28. PMID: 32474045; PMCID: PMC7255712.

12.Min YQ, Ning YJ, Wang H, Deng F. A RIG-I-like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination. J Biol Chem. 2020 Jul 10;295(28):9691-9711. doi: 10.1074/jbc.RA120.013973. Epub 2020 May 29. PMID: 32471869; PMCID: PMC7363118.

13.Zhang H, Kuang W, Chen C, Shang Y, Ma X, Deng F, Wang H, Wang M, Hu Z. Per Os Infectivity Factor 5 Identified as a Substrate of P33 in the Baculoviral Disulfide Bond Formation Pathway. J Virol. 2020 Jul 16;94(15):e00615-20. doi: 10.1128/JVI.00615-20. PMID: 32434885; PMCID: PMC7375385.

14.Wang X, Cao R, Zhang H, Liu J, Xu M, Hu H, Li Y, Zhao L, Li W, Sun X, Yang X, Shi Z, Deng F, Hu Z, Zhong W, Wang M. The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro. Cell Discov. 2020 May 2;6:28. doi: 10.1038/s41421-020-0169-8. PMID: 32373347; PMCID: PMC7195821.

15.Wang P, Liu L, Liu A, Yan L, He Y, Shen S, Hu M, Guo Y, Liu H, Liu C, Lu Y, Wang P, Deng F, Rao Z, Lou Z. Structure of severe fever with thrombocytopenia syndrome virus L protein elucidates the mechanisms of viral transcription initiation. Nat Microbiol. 2020 Jun;5(6):864-871. doi: 10.1038/s41564-020-0712-2. Epub 2020 Apr 27. PMID: 32341479.

16.Ren F, Zhou M, Deng F, Wang H, Ning YJ. Combinatorial Minigenome Systems for Emerging Banyangviruses Reveal Viral Reassortment Potential and Importance of a Protruding Nucleotide in Genome "Panhandle" for Promoter Activity and Reassortment. Front Microbiol. 2020 Apr 8;11:599. doi: 10.3389/fmicb.2020.00599. PMID: 32322247; PMCID: PMC7156889.

17.Zohaib A, Saqib M, Athar MA, Hussain MH, Sial AU, Tayyab MH, Batool M, Sadia H, Taj Z, Tahir U, Jakhrani MY, Tayyab J, Kakar MA, Shahid MF, Yaqub T, Zhang J, Wu Q, Deng F, Corman VM, Shen S, Khan I, Shi ZL. Crimean-Congo Hemorrhagic Fever Virus in Humans and Livestock, Pakistan, 2015-2017. Emerg Infect Dis. 2020 Apr;26(4):773-777. doi: 10.3201/eid2604.191154. PMID: 32187506; PMCID: PMC7101105.

18.Min YQ, Shi C, Yao T, Feng K, Mo Q, Deng F, Wang H, Ning YJ. The Nonstructural Protein of Guertu Virus Disrupts Host Defenses by Blocking Antiviral Interferon Induction and Action. ACS Infect Dis. 2020 May 8;6(5):857-870. doi: 10.1021/acsinfecdis.9b00492. Epub 2020 Mar 20. PMID: 32167734.

19.Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, Si HR, Zhu Y, Li B, Huang CL, Chen HD, Chen J, Luo Y, Guo H, Jiang RD, Liu MQ, Chen Y, Shen XR, Wang X, Zheng XS, Zhao K, Chen QJ, Deng F, Liu LL, Yan B, Zhan FX, Wang YY, Xiao GF, Shi ZL. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020 Mar;579(7798):270-273. doi: 10.1038/s41586-020-2012-7. Epub 2020 Feb 3. PMID: 32015507; PMCID: PMC7095418.

20.Shi J, Li W, Wang Y, Chen Q, Deng F. Meta-Transcriptome Profiling of Novel Invasive Pest Spodoptera frugiperda in Yunnan, China. Virol Sin. 2020 Apr;35(2):240-244. doi: 10.1007/s12250-019-00188-z. Epub 2020 Jan 8. PMID: 31916023; PMCID: PMC7198670.

21.Liu X, Wang H, Liu X, Li Y, Chen J, Zhang J, Wang X, Shen S, Wang H, Deng F, Wang M, Guan W, Hu Z. Genomic and transcriptional analyses of novel parvoviruses identified from dead peafowl. Virology. 2020 Jan 2;539:80-91. doi: 10.1016/j.virol.2019.10.013. Epub 2019 Oct 31. PMID: 31706163.

22.Wang J, Yang M, Xiao H, Huang GH, Deng F, Hu Z. Genome Analysis of Dasineura jujubifolia Toursvirus 2, A Novel Ascovirus. Virol Sin. 2020 Apr;35(2):134-142. doi: 10.1007/s12250-019-00177-2. Epub 2019 Nov 29. PMID: 31784872; PMCID: PMC7198669.

23.Liu D, Guo S, Zou M, Chen C, Deng F, Xie Z, Hu S, Wu L. A dengue fever predicting model based on Baidu search index data and climate data in South China. PLoS One. 2019 Dec 30;14(12):e0226841. doi: 10.1371/journal.pone.0226841. PMID: 31887118; PMCID: PMC6936853.

24.Zhang J, Simayi A, Wang M, Moming A, Xu W, Wang C, Li Y, Ding J, Deng F, Zhang Y, Sun S. Fine mapping epitope on glycoprotein Gc from Crimean-Congo hemorrhagic fever virus. Comp Immunol Microbiol Infect Dis. 2019 Dec;67:101371. doi: 10.1016/j.cimid.2019.101371. Epub 2019 Oct 10. PMID: 31627038.

25.Zhang J, Moming A, Yue X, Shen S, Liu D, Xu WX, Wang C, Ding J, Li Y, Deng F, Zhang Y, Sun S. Fine epitope mapping of glycoprotein Gn in Guertu virus. PLoS One. 2019 Oct 16;14(10):e0223978. doi: 10.1371/journal.pone.0223978. PMID: 31618247; PMCID: PMC6795428.

26.Li J, Duan X, Wang Q, Zhang L, Deng F, Wang H, Hu Z, Wang M, Wang J. Genome Analysis of a Novel Clade II.b Alphabaculovirus Obtained from Artaxa digramma. Viruses. 2019 Oct 9;11(10):925. doi: 10.3390/v11100925. PMID: 31601038; PMCID: PMC6832367.

27.Hou D, Kuang W, Luo S, Zhang F, Zhou F, Chen T, Zhang Y, Wang H, Hu Z, Deng F, Wang M. Baculovirus ODV-E66 degrades larval peritrophic membrane to facilitate baculovirus oral infection. Virology. 2019 Nov;537:157-164. doi: 10.1016/j.virol.2019.08.027. Epub 2019 Aug 29. PMID: 31493654.

28.Li H, Zhang LK, Li SF, Zhang SF, Wan WW, Zhang YL, Xin QL, Dai K, Hu YY, Wang ZB, Zhu XT, Fang YJ, Cui N, Zhang PH, Yuan C, Lu QB, Bai JY, Deng F, Xiao GF, Liu W, Peng K. Calcium channel blockers reduce severe fever with thrombocytopenia syndrome virus (SFTSV) related fatality. Cell Res. 2019 Sep;29(9):739-753. doi: 10.1038/s41422-019-0214-z. Epub 2019 Aug 23. PMID: 31444469; PMCID: PMC6796935.

29.Zhu L, Yin F, Moming A, Zhang J, Wang B, Gao L, Ruan J, Wu Q, Wu N, Wang H, Deng F, Lu G, Shen S. First case of laboratory-confirmed severe fever with thrombocytopenia syndrome disease revealed the risk of SFTSV infection in Xinjiang, China. Emerg Microbes Infect. 2019;8(1):1122-1125. doi: 10.1080/22221751.2019.1645573. PMID: 31347462; PMCID: PMC6711166.

30.Li S, Wang Y, Hou D, Guan Z, Shen S, Peng K, Deng F, Chen X, Hu Z, Wang H, Wang M. Host factor heat-shock protein 90 contributes to baculovirus budded virus morphogenesis via facilitating nuclear actin polymerization. Virology. 2019 Sep;535:200-209. doi: 10.1016/j.virol.2019.07.006. Epub 2019 Jul 5. PMID: 31319277.

31.Shao W, He L, Chen Q, Li J, Deng F, Wang H, Hu Z, Wang M. Functional Characterization of the Group I Alphabaculovirus Specific Gene ac73. Virol Sin. 2019 Dec;34(6):701-711. doi: 10.1007/s12250-019-00146-9. Epub 2019 Jul 17. PMID: 31317397; PMCID: PMC6888964.

32.Zhou F, Kuang W, Wang X, Hou D, Huang H, Sun X, Deng F, Wang H, van Oers MM, Wang M, Hu Z. The cysteine-rich region of a baculovirus VP91 protein contributes to the morphogenesis of occlusion bodies. Virology. 2019 Sep;535:144-153. doi: 10.1016/j.virol.2019.06.016. Epub 2019 Jul 3. PMID: 31302508.

33.Li LL, Liu MM, Shen S, Zhang YJ, Xu YL, Deng HY, Deng F, Duan ZJ. Detection and characterization of a novel hepacivirus in long-tailed ground squirrels (Spermophilus undulatus) in China. Arch Virol. 2019 Sep;164(9):2401-2410. doi: 10.1007/s00705-019-04303-z. Epub 2019 Jun 18. PMID: 31243554.

34.Hu L, Li Y, Deng F, Hu Z, Wang H, Wang M. Improving Baculovirus Transduction of Mammalian Cells by Incorporation of Thogotovirus Glycoproteins. Virol Sin. 2019 Aug;34(4):454-466. doi: 10.1007/s12250-019-00133-0. Epub 2019 Jun 14. PMID: 31201733; PMCID: PMC6687793.

35.Ning YJ, Mo Q, Feng K, Min YQ, Li M, Hou D, Peng C, Zheng X, Deng F, Hu Z, Wang H. Interferon-γ-Directed Inhibition of a Novel High-Pathogenic Phlebovirus and Viral Antagonism of the Antiviral Signaling by Targeting STAT1. Front Immunol. 2019 May 28;10:1182. doi: 10.3389/fimmu.2019.01182. PMID: 31191546; PMCID: PMC6546826.

36.Li W, Li N, Dai S, Hou G, Guo K, Chen X, Yi C, Liu W, Deng F, Wu Y, Cao X. Zika virus circumvents host innate immunity by targeting the adaptor proteins MAVS and MITA. FASEB J. 2019 Sep;33(9):9929-9944. doi: 10.1096/fj.201900260R. Epub 2019 Jun 10. PMID: 31180720.

37.Hu L, Li Y, Ning YJ, Deng F, Vlak JM, Hu Z, Wang H, Wang M. The Major Hurdle for Effective Baculovirus Transduction into Mammalian Cells Is Passing Early Endosomes. J Virol. 2019 Jul 17;93(15):e00709-19. doi: 10.1128/JVI.00709-19. PMID: 31092570; PMCID: PMC6639295.

38.Abudurexiti A, Adkins S, Alioto D, Alkhovsky SV, Av？i？-？upanc T, Ballinger MJ, Bente DA, Beer M, Bergeron é, Blair CD, Briese T, Buchmeier MJ, Burt FJ, Calisher CH, Cháng C, Charrel RN, Choi IR, Clegg JCS, de la Torre JC, de Lamballerie X, Dèng F, Di Serio F, Digiaro M, Drebot MA, Duàn X, Ebihara H, Elbeaino T, Ergünay K, Fulhorst CF, Garrison AR, Gāo GF, Gonzalez JJ, Groschup MH, Günther S, Haenni AL, Hall RA, Hepojoki J, Hewson R, Hú Z, Hughes HR, Jonson MG, Junglen S, Klempa B, Klingstr？m J, Kòu C, Laenen L, Lambert AJ, Langevin SA, Liu D, Lukashevich IS, Luò T, Lǚ C, Maes P, de Souza WM, Marklewitz M, Martelli GP, Matsuno K, Mielke-Ehret N, Minutolo M, Mirazimi A, Moming A, Mühlbach HP, Naidu R, Navarro B, Nunes MRT, Palacios G, Papa A, Pauvolid-Corrêa A, Paw？ska JT, Qiáo J, Radoshitzky SR, Resende RO, Romanowski V, Sall AA, Salvato MS, Sasaya T, Shěn S, Shí X, Shirako Y, Simmonds P, Sironi M, Song JW, Spengler JR, Stenglein MD, Sū Z, Sūn S, Táng S, Turina M, Wáng B, Wáng C, Wáng H, Wáng J, Wèi T, Whitfield AE, Zerbini FM, Zhāng J, Zhāng L, Zhāng Y, Zhang YZ, Zhāng Y, Zhou X, Zhū L, Kuhn JH. Taxonomy of the order Bunyavirales: update 2019. Arch Virol. 2019 Jul;164(7):1949-1965. doi: 10.1007/s00705-019-04253-6. Epub 2019 May 7. PMID: 31065850; PMCID: PMC6641860.

39.Feng K, Deng F, Hu Z, Wang H, Ning YJ. Heartland virus antagonizes type I and III interferon antiviral signaling by inhibiting phosphorylation and nuclear translocation of STAT2 and STAT1. J Biol Chem. 2019 Jun 14;294(24):9503-9517. doi: 10.1074/jbc.RA118.006563. Epub 2019 Apr 30. PMID: 31040183; PMCID: PMC6579454.

40.Zhang LK, Wang B, Xin Q, Shang W, Shen S, Xiao G, Deng F, Wang H, Hu Z, Wang M. Quantitative Proteomic Analysis Reveals Unfolded-Protein Response Involved in Severe Fever with Thrombocytopenia Syndrome Virus Infection. J Virol. 2019 May 1;93(10):e00308-19. doi: 10.1128/JVI.00308-19. PMID: 30842332; PMCID: PMC6498065.

41.Dong F, Li D, Wen D, Li S, Zhao C, Qi Y, Jangra RK, Wu C, Xia D, Zhang X, Deng F, Chandran K, Zou Z, Yuan F, Zheng A. Single dose of a rVSV-based vaccine elicits complete protection against severe fever with thrombocytopenia syndrome virus. NPJ Vaccines. 2019 Jan 25;4:5. doi: 10.1038/s41541-018-0096-y. PMID: 30701094; PMCID: PMC6347601.

42.Wang X, Shang Y, Chen C, Liu S, Chang M, Zhang N, Hu H, Zhang F, Zhang T, Wang Z, Liu X, Lin Z, Deng F, Wang H, Zou Z, Vlak JM, Wang M, Hu Z. Baculovirus Per Os Infectivity Factor Complex: Components and Assembly. J Virol. 2019 Mar 5;93(6):e02053-18. doi: 10.1128/JVI.02053-18. PMID: 30602603; PMCID: PMC6401453.

43.Liu J, Xu M, Tang B, Hu L, Deng F, Wang H, Pang DW, Hu Z, Wang M, Zhou Y. Single-Particle Tracking Reveals the Sequential Entry Process of the Bunyavirus Severe Fever with Thrombocytopenia Syndrome Virus. Small. 2019 Feb;15(6):e1803788. doi: 10.1002/smll.201803788. Epub 2018 Dec 27. PMID: 30589216.

44.Chen Y, Qi B, Zheng G, Zhang Y, Deng F, Wan F, Li C. Identification and genomic sequence analysis of a new Spodoptera exigua multiple nucleopolyhedrovirus, SeMNPV-QD, isolated from Qingdao, China. J Invertebr Pathol. 2019 Jan;160:8-17. doi: 10.1016/j.jip.2018.11.006. Epub 2018 Nov 26. PMID: 30496755.

45.Hao H, Hao S, Chen H, Chen Z, Zhang Y, Wang J, Wang H, Zhang B, Qiu J, Deng F, Guan W. N6-methyladenosine modification and METTL3 modulate enterovirus 71 replication. Nucleic Acids Res. 2019 Jan 10;47(1):362-374. doi: 10.1093/nar/gky1007. PMID: 30364964; PMCID: PMC6326802.

46.Shen S, Duan X, Wang B, Zhu L, Zhang Y, Zhang J, Wang J, Luo T, Kou C, Liu D, Lv C, Zhang L, Chang C, Su Z, Tang S, Qiao J, Moming A, Wang C, Abudurexiti A, Wang H, Hu Z, Zhang Y, Sun S, Deng F. A novel tick-borne phlebovirus, closely related to severe fever with thrombocytopenia syndrome virus and Heartland virus, is a potential pathogen. Emerg Microbes Infect. 2018 May 25;7(1):95. doi: 10.1038/s41426-018-0093-2. PMID: 29802259; PMCID: PMC5970217.

47.Shalitanati A, Yu H, Liu D, Xu WX, Yue X, Guo R, Li Y, Deng F, Yang J, Zhang Y, Sun S. Fine mapping epitope on glycoprotein-Gn from Crimean-Congo hemorrhagic fever virus. Comp Immunol Microbiol Infect Dis. 2018 Aug;59:24-31. doi: 10.1016/j.cimid.2018.09.003. Epub 2018 Sep 11. PMID: 30290884.

48.Moming A, Tuoken D, Yue X, Xu W, Guo R, Liu D, Li Y, Hu Z, Deng F, Zhang Y, Sun S. Mapping of B-cell epitopes on the N- terminal and C-terminal segment of nucleocapsid protein from Crimean-Congo hemorrhagic fever virus. PLoS One. 2018 Sep 20;13(9):e0204264. doi: 10.1371/journal.pone.0204264. PMID: 30235312; PMCID: PMC6147494.

49.Zhu Z, Wang J, Wang Q, Yin F, Liu X, Hou D, Zhang L, Liu H, Li J, Arif BM, Wang H, Deng F, Hu Z, Wang M. Genome Characteristics of the Cyclophragma Undans Nucleopolyhedrovirus: A Distinct Species in Group I of Alphabaculovirus. Virol Sin. 2018 Aug;33(4):359-368. doi: 10.1007/s12250-018-0047-9. Epub 2018 Aug 28. PMID: 30155853; PMCID: PMC6178095.

50.Dai S, Zhang Y, Zhang T, Zhang B, Wang H, Deng F. Establishment of Baculovirus-Expressed VLPs Induced Syncytial Formation Assay for Flavivirus Antiviral Screening. Viruses. 2018 Jul 11;10(7):365. doi: 10.3390/v10070365. PMID: 29997331; PMCID: PMC6071280.

51.Dai S, Zhang T, Zhang Y, Wang H, Deng F. Zika Virus Baculovirus-Expressed Virus-Like Particles Induce Neutralizing Antibodies in Mice. Virol Sin. 2018 Jun;33(3):213-226. doi: 10.1007/s12250-018-0030-5. Epub 2018 May 17. PMID: 29774519; PMCID: PMC6013542.

52.Li Y, Shen S, Hu L, Deng F, Vlak JM, Hu Z, Wang H, Wang M. The Functional Oligomeric State of Tegument Protein GP41 Is Essential for Baculovirus Budded Virion and Occlusion-Derived Virion Assembly. J Virol. 2018 May 29;92(12):e02083-17. doi: 10.1128/JVI.02083-17. PMID: 29643237; PMCID: PMC5974493.

53.Makalliwa GA, Wang X, Zhang H, Zhang N, Chen C, Li J, Deng F, Wang H, Wang M, Hu Z. HearNPV Pseudotyped with PIF1, 2, and 3 from MabrNPV: Infectivity and Complex Stability. Virol Sin. 2018 Apr;33(2):187-196. doi: 10.1007/s12250-018-0014-5. Epub 2018 Mar 16. PMID: 29549650; PMCID: PMC6178116.

54.Shi J, Hu Z, Deng F, Shen S. Tick-Borne Viruses. Virol Sin. 2018 Feb;33(1):21-43. doi: 10.1007/s12250-018-0019-0. Epub 2018 Mar 13. PMID: 29536246; PMCID: PMC5866268.

55.Moming A, Yue X, Shen S, Chang C, Wang C, Luo T, Zhang Y, Guo R, Hu Z, Zhang Y, Deng F, Sun S. Prevalence and Phylogenetic Analysis of Crimean-Congo Hemorrhagic Fever Virus in Ticks from Different Ecosystems in Xinjiang, China. Virol Sin. 2018 Feb;33(1):67-73. doi: 10.1007/s12250-018-0016-3. Epub 2018 Mar 9. PMID: 29524182; PMCID: PMC6178079.

56.Zhang Y, Shen S, Fang Y, Liu J, Su Z, Liang J, Zhang Z, Wu Q, Wang C, Abudurexiti A, Hu Z, Zhang Y, Deng F. Isolation, Characterization, and Phylogenetic Analysis of Two New Crimean-Congo Hemorrhagic Fever Virus Strains from the Northern Region of Xinjiang Province, China. Virol Sin. 2018 Feb;33(1):74-86. doi: 10.1007/s12250-018-0020-7. Epub 2018 Mar 8. PMID: 29520745; PMCID: PMC6178084.

57.Li Y, Ni L, Chen J, Yang J, Deng F, Wang H. Development of Multi-analyte Suspension Assay for Simultaneously Efficient Detection of Avian Influenza Virus A Subtypes. Virol Sin. 2018 Feb;33(1):111-115. doi: 10.1007/s12250-018-0018-1. Epub 2018 Mar 2. PMID: 29500693; PMCID: PMC6178083.

58.Wang X, Chen C, Zhang N, Li J, Deng F, Wang H, Vlak JM, Hu Z, Wang M. The group I alphabaculovirus-specific protein, AC5, is a novel component of the occlusion body but is not associated with ODVs or the PIF complex. J Gen Virol. 2018 Apr;99(4):585-595. doi: 10.1099/jgv.0.001031. Epub 2018 Feb 21. PMID: 29465345.

59.Wang J, Hou D, Wang Q, Kuang W, Zhang L, Li J, Shen S, Deng F, Wang H, Hu Z, Wang M. Genome analysis of a novel Group I alphabaculovirus obtained from Oxyplax ochracea. PLoS One. 2018 Feb 1;13(2):e0192279. doi: 10.1371/journal.pone.0192279. PMID: 29390020; PMCID: PMC5794183.

60.Ning YJ, Kang Z, Xing J, Min YQ, Liu D, Feng K, Wang M, Deng F, Zhou Y, Hu Z, Wang H. Ebola virus mucin-like glycoprotein (Emuc) induces remarkable acute inflammation and tissue injury: evidence for Emuc pathogenicity in vivo. Protein Cell. 2018 Apr;9(4):389-393. doi: 10.1007/s13238-017-0471-x. PMID: 28956289; PMCID: PMC5876185.

61.Liu SQ, Li X, Zhang YN, Gao AL, Deng CL, Li JH, Jehan S, Jamil N, Deng F, Wei H, Zhang B. Detection, isolation, and characterization of chikungunya viruses associated with the Pakistan outbreak of 2016-2017. Virol Sin. 2017 Dec;32(6):511-519. doi: 10.1007/s12250-017-4059-7. Epub 2017 Dec 21. PMID: 29285673; PMCID: PMC6598907.

62.Shi J, Su Z, Fan Z, Wang J, Liu S, Zhang B, Wei H, Jehan S, Jamil N, Shen S, Deng F. Extensive evolution analysis of the global chikungunya virus strains revealed the origination of CHIKV epidemics in Pakistan in 2016. Virol Sin. 2017 Dec;32(6):520-532. doi: 10.1007/s12250-017-4077-5. Epub 2017 Dec 11. PMID: 29243070; PMCID: PMC6598911.

63.Du R, Wang L, Xu H, Wang Z, Zhang T, Wang M, Ning Y, Deng F, Hu Z, Wang H, Li Y. A novel glycoprotein D-specific monoclonal antibody neutralizes herpes simplex virus. Antiviral Res. 2017 Nov;147:131-141. doi: 10.1016/j.antiviral.2017.10.013. Epub 2017 Oct 20. PMID: 29061442; PMCID: PMC7113901.

64.Kuang W, Zhang H, Wang M, Zhou NY, Deng F, Wang H, Gong P, Hu Z. Three Conserved Regions in Baculovirus Sulfhydryl Oxidase P33 Are Critical for Enzymatic Activity and Function. J Virol. 2017 Nov 14;91(23):e01158-17. doi: 10.1128/JVI.01158-17. PMID: 28904203; PMCID: PMC5686738.

65.Ning YJ, Feng K, Min YQ, Deng F, Hu Z, Wang H. Heartland virus NSs protein disrupts host defenses by blocking the TBK1 kinase-IRF3 transcription factor interaction and signaling required for interferon induction. J Biol Chem. 2017 Oct 6;292(40):16722-16733. doi: 10.1074/jbc.M117.805127. Epub 2017 Aug 28. PMID: 28848048; PMCID: PMC5633133.

66.Huang D, Jiang Y, Liu X, Wang B, Shi J, Su Z, Wang H, Wang T, Tang S, Liu H, Hu Z, Deng F, Shen S. A Cluster of Symptomatic and Asymptomatic Infections of Severe Fever with Thrombocytopenia Syndrome Caused by Person-to-Person Transmission. Am J Trop Med Hyg. 2017 Aug;97(2):396-402. doi: 10.4269/ajtmh.17-0059. Epub 2017 Jul 19. PMID: 28722592; PMCID: PMC5544100.

67.Xin QL, Deng CL, Chen X, Wang J, Wang SB, Wang W, Deng F, Zhang B, Xiao G, Zhang LK. Quantitative Proteomic Analysis of Mosquito C6/36 Cells Reveals Host Proteins Involved in Zika Virus Infection. J Virol. 2017 May 26;91(12):e00554-17. doi: 10.1128/JVI.00554-17. PMID: 28404849; PMCID: PMC5446628.

68.Shang Y, Wang M, Xiao G, Wang X, Hou D, Pan K, Liu S, Li J, Wang J, Arif BM, Vlak JM, Chen X, Wang H, Deng F, Hu Z. Construction and Rescue of a Functional Synthetic Baculovirus. ACS Synth Biol. 2017 Jul 21;6(7):1393-1402. doi: 10.1021/acssynbio.7b00028. Epub 2017 Apr 6. PMID: 28383905.

69.Guo R, Shen S, Zhang Y, Shi J, Su Z, Liu D, Liu J, Yang J, Wang Q, Hu Z, Zhang Y, Deng F. A new strain of Crimean-Congo hemorrhagic fever virus isolated from Xinjiang, China. Virol Sin. 2017 Feb;32(1):80-88. doi: 10.1007/s12250-016-3936-9. Epub 2017 Feb 27. PMID: 28251517; PMCID: PMC6598972.

70.Zhang Y, Shen S, Shi J, Su Z, Li M, Zhang W, Li M, Hu Z, Peng C, Zheng X, Deng F. Isolation, characterization, and phylogenic analysis of three new severe fever with thrombocytopenia syndrome bunyavirus strains derived from Hubei Province, China. Virol Sin. 2017 Feb;32(1):89-96. doi: 10.1007/s12250-017-3953-3. Epub 2017 Feb 24. PMID: 28251516; PMCID: PMC6598898.

71.Moming A, Zhang Y, Chang C, Yu H, Wang M, Hu Z, Deng F, Sun S. Antigenicity of severe fever with thrombocytopenia syndrome virus nucleocapsid protein and its potential application in the virus serodiagnosis. Virol Sin. 2017 Feb;32(1):97-100. doi: 10.1007/s12250-016-3928-9. PMID: 28120219; PMCID: PMC6598900.

72.Shi J, Hu S, Liu X, Yang J, Liu D, Wu L, Wang H, Hu Z, Deng F, Shen S. Migration, recombination, and reassortment are involved in the evolution of severe fever with thrombocytopenia syndrome bunyavirus. Infect Genet Evol. 2017 Jan;47:109-117. doi: 10.1016/j.meegid.2016.11.015. Epub 2016 Nov 21. PMID: 27884653.

73.Ning YJ, Deng F, Hu Z, Wang H. The roles of ebolavirus glycoproteins in viral pathogenesis. Virol Sin. 2017 Feb;32(1):3-15. doi: 10.1007/s12250-016-3850-1. Epub 2016 Nov 14. PMID: 27853993; PMCID: PMC6791933.

74.Zou Z, Liu J, Wang Z, Deng F, Wang H, Hu Z, Wang M, Zhang T. Characterization of two monoclonal antibodies, 38F10 and 44D11, against the major envelope fusion protein of Helicoverpa armigera nucleopolyhedrovirus. Virol Sin. 2016 Dec;31(6):490-499. doi: 10.1007/s12250-016-3831-4. Epub 2016 Dec 16. PMID: 27995421.

75.Ning YJ, Deng F, Hu Z, Wang H. The roles of ebolavirus glycoproteins in viral pathogenesis. Virol Sin. 2017 Feb;32(1):3-15. doi: 10.1007/s12250-016-3850-1. Epub 2016 Nov 14. PMID: 27853993; PMCID: PMC6791933.

76.Wu L, Deng F, Xie Z, Hu S, Shen S, Shi J, Liu D. Spatial Analysis of Severe Fever with Thrombocytopenia Syndrome Virus in China Using a Geographically Weighted Logistic Regression Model. Int J Environ Res Public Health. 2016 Nov 11;13(11):1125. doi: 10.3390/ijerph13111125. PMID: 27845737; PMCID: PMC5129335.

77.Wang X, Li B, Guo Y, Shen S, Zhao L, Zhang P, Sun Y, Sui SF, Deng F, Lou Z. Molecular basis for the formation of ribonucleoprotein complex of Crimean-Congo hemorrhagic fever virus. J Struct Biol. 2016 Dec;196(3):455-465. doi: 10.1016/j.jsb.2016.09.013. Epub 2016 Sep 22. PMID: 27666016.

78.Song J, Wang X, Hou D, Huang H, Liu X, Deng F, Wang H, Arif BM, Hu Z, Wang M. The Host Specificities of Baculovirus per os Infectivity Factors. PLoS One. 2016 Jul 25;11(7):e0159862. doi: 10.1371/journal.pone.0159862. PMID: 27454435; PMCID: PMC4959699.

79.Liu J, Dai S, Wang M, Hu Z, Wang H, Deng F. Virus like particle-based vaccines against emerging infectious disease viruses. Virol Sin. 2016 Aug;31(4):279-87. doi: 10.1007/s12250-016-3756-y. Epub 2016 Jul 11. PMID: 27405928; PMCID: PMC7090901.

80.Xing J, Liu D, Shen S, Su Z, Zhang L, Duan Y, Tong F, Liang Y, Wang H, Deng F, Hu Z, Zhou Y. Pathologic Studies of Fatal Encephalomyelitis in Children Caused by Enterovirus 71. Am J Clin Pathol. 2016 Jul;146(1):95-106. doi: 10.1093/ajcp/aqw089. Epub 2016 Jun 29. PMID: 27357294.

81.Kuang W, Zhang H, Hou D, Wang M, Deng F, Wang H, Hu Z. P33 of Helicoverpa armigera single nucleocapsid nucleopolyhedrovirus is a functional homolog of AcP33. Virol Sin. 2016 Aug;31(4):346-9. doi: 10.1007/s12250-016-3771-z. PMID: 27167377.

82.Wang J, Zhu Z, Zhang L, Hou D, Wang M, Arif B, Kou Z, Wang H, Deng F, Hu Z. Genome Sequencing and Analysis of Catopsilia pomona nucleopolyhedrovirus: A Distinct Species in Group I Alphabaculovirus. PLoS One. 2016 May 11;11(5):e0155134. doi: 10.1371/journal.pone.0155134. PMID: 27166956; PMCID: PMC4864199.

83.Yin F, Du R, Kuang W, Yang G, Wang H, Deng F, Hu Z, Wang M. Characterization of the viral fibroblast growth factor homolog of Helicoverpa armigera single nucleopolyhedrovirus. Virol Sin. 2016 Jun;31(3):240-8. doi: 10.1007/s12250-016-3710-z. Epub 2016 Apr 28. PMID: 27142667.

84.Shen S, Shi J, Wang J, Tang S, Wang H, Hu Z, Deng F. Phylogenetic analysis revealed the central roles of two African countries in the evolution and worldwide spread of Zika virus. Virol Sin. 2016 Apr;31(2):118-30. doi: 10.1007/s12250-016-3774-9. Epub 2016 Apr 26. PMID: 27129451.

85.Liu S, Li M, Su Z, Deng F, Chen J. A 3-year follow-up study of the seroprevalence of antibodies to avian influenza A H5, H6, H7 and H10 viruses among the general population of Wuhan, China. J Clin Virol. 2016 Apr;77:109-10. doi: 10.1016/j.jcv.2016.02.018. Epub 2016 Feb 22. PMID: 26945873.

86.Shen S, Wang M, Li X, Li S, van Oers MM, Vlak JM, Braakman I, Hu Z, Deng F, Wang H. Mutational and functional analysis of N-linked glycosylation of envelope fusion protein F of Helicoverpa armigera nucleopolyhedrovirus. J Gen Virol. 2016 Apr;97(4):988-999. doi: 10.1099/jgv.0.000404. Epub 2016 Jan 14. PMID: 26769631.

87.Guo Y, Wang W, Sun Y, Ma C, Wang X, Wang X, Liu P, Shen S, Li B, Lin J, Deng F, Wang H, Lou Z. Crystal Structure of the Core Region of Hantavirus Nucleocapsid Protein Reveals the Mechanism for Ribonucleoprotein Complex Formation. J Virol. 2015 Nov 11;90(2):1048-61. doi: 10.1128/JVI.02523-15. PMID: 26559827; PMCID: PMC4702685.

88.Zhang S, Zhu Z, Sun S, Chen Q, Deng F, Yang K. Genome sequencing and analysis of a granulovirus isolated from the Asiatic rice leafroller, Cnaphalocrocis medinalis. Virol Sin. 2015 Dec;30(6):417-24. doi: 10.1007/s12250-015-3658-4. Epub 2015 Dec 18. PMID: 26712716.

89.Du R, Wang M, Hu Z, Wang H, Deng F. An in vitro recombination-based reverse genetic system for rapid mutagenesis of structural genes of the Japanese encephalitis virus. Virol Sin. 2015 Oct;30(5):354-62. doi: 10.1007/s12250-015-3623-2. Epub 2015 Sep 30. PMID: 26463213.

90.Yin F, Wu Z, Fang W, Wu C, Rayner S, Han M, Deng F, Du R, Liu J, Wang M, Wang H, Ning Q, Hu Z. Resistant mutations and quasispecies complexity of hepatitis B virus during telbivudine treatment. J Gen Virol. 2015 Nov;96(11):3302-3312. doi: 10.1099/jgv.0.000285. Epub 2015 Sep 16. PMID: 26382925.

91.Yin F, Zhu Z, Liu X, Hou D, Wang J, Zhang L, Wang M, Kou Z, Wang H, Deng F, Hu Z. The Complete Genome of a New Betabaculovirus from Clostera anastomosis. PLoS One. 2015 Jul 13;10(7):e0132792. doi: 10.1371/journal.pone.0132792. PMID: 26168260; PMCID: PMC4500397.

92.Li S, Wang M, Shen S, Hu Z, Wang H, Deng F. The FP25K Acts as a Negative Factor for the Infectivity of AcMNPV Budded Virus. PLoS One. 2015 May 28;10(5):e0128471. doi: 10.1371/journal.pone.0128471. PMID: 26020780; PMCID: PMC4447387.

93.Ning YJ, Feng K, Min YQ, Cao WC, Wang M, Deng F, Hu Z, Wang H. Disruption of type I interferon signaling by the nonstructural protein of severe fever with thrombocytopenia syndrome virus via the hijacking of STAT2 and STAT1 into inclusion bodies. J Virol. 2015 Apr;89(8):4227-36. doi: 10.1128/JVI.00154-15. Epub 2015 Jan 28. PMID: 25631085; PMCID: PMC4442386.

94.Du R, Yin F, Wang M, Hu Z, Wang H, Deng F. Glycoprotein E of the Japanese encephalitis virus forms virus-like particles and induces syncytia when expressed by a baculovirus. J Gen Virol. 2015 May;96(Pt 5):1006-1014. doi: 10.1099/vir.0.000052. Epub 2015 Jan 15. PMID: 25593161.

专利：

一种可进行生物安全操作的冷冻干燥装置；唐霜，邓菲，吴巧丽，张忠，唐小东；ZL 2017 2 1487074.8；中国科学院武汉病毒研究所