沈姝

姓       名：沈姝

职称职务：青年研究员

电子邮箱：shenshu@wh.iov.cn

研究方向

1.发现、鉴定和分离（蜱传）新病毒

2.蜱传病毒潜在感染致病风险调查与致病机制研究

3.病毒感染与血小板应答和出血机制研究

4.蜱类携带病毒与传播分子机制及防治手段研究

教育及工作经历

2001.09-2005.07   武汉大学生命科学院        生物科学    学士

2006.09-2012.07   中国科学院武汉病毒研究所  微生物学    博士

2012.08-2018.07   中国科学院武汉病毒研究所  助理研究员

2018.08--至今      中国科学院武汉病毒研究所  副研究员

2021.08-至今      中国科学院武汉病毒研究所  青年研究员

近五年承担项目

主持和承担国家重点研发计划、国家自然科学基金青年项目、中国科学院战略先导科技专项、湖北省自然科学基金项目等。

近五年代表性论文

1: Shen S, Zhang Y, Yin Z, Zhu Q, Zhang J, Wang T, Fang Y, Wu X, Bai Y, Dai S, Liu X, Jin J, Tang S, Liu J, Wang M, Guo Y, Deng F. Antiviral activity and mechanism of the antifungal drug, anidulafungin, suggesting its potential to promote treatment of viral diseases. BMC Med. 2022 Oct 21;20(1):359. doi: 10.1186/s12916-022-02558-z. PMID: 36266654; PMCID: PMC9585728.

2: Yin Z, Ren F, Zhou M, Chen S, Deng Y, Hu S, Deng F, Shen S, Shi J. Roles of the functional domains and conserved residues of the severe fever with thrombocytopenia syndrome virus L protein provide insights into the viral RNA transcription/replication mechanism. Virol Sin. 2022 Sep 3:S1995-820X(22)00148-1. doi: 10.1016/j.virs.2022.08.009. Epub ahead of print. PMID: 36064095.

3: Wang J, Xiao J, Zhu Z, Wang S, Zhang L, Fan Z, Deng Y, Hu Z, Peng F, Shen S, Deng F. Diverse viromes in polar regions: A retrospective study of metagenomic data from Antarctic animal feces and Arctic frozen soil in 2012-2014. Virol Sin. 2022 Aug 24:S1995-820X(22)00145-6. doi: 10.1016/j.virs.2022.08.006. Epub ahead of print. PMID: 36028202.

4: Bai Y, Zhang Y, Su Z, Tang S, Wang J, Wu Q, Yang J, Moming A, Zhang Y, Bell-Sakyi L, Sun S, Shen S, Deng F. Discovery of Tick-Borne Karshi Virus Implies Misinterpretation of the Tick-Borne Encephalitis Virus Seroprevalence in Northwest China. Front Microbiol. 2022 May 3;13:872067. doi:10.3389/fmicb.2022.872067. PMID: 35685931; PMCID: PMC9173002.

5: Zhang P, Su H, Peng R, Chan JF, Bai S, Wang G, Huang Y, Hu X, Luo J, Liu S, Li Y, Xue L, Yang F, Zhao M, Zhang Y, Tang C, Shen S, Cui X, Niu L, Lu G, Yuen KY, Deng F, Zhang W, Yin F, Du J. Identification of a Novel Astrovirus in Pinnipeds. Front Microbiol. 2022 May 4;13:845601. doi:10.3389/fmicb.2022.845601. PMID: 35602043; PMCID: PMC9116510.

6: Chen S, Xu M, Wu X, Bai Y, Shi J, Zhou M, Wu Q, Tang S, Deng F, Qin B, Shen S. A new luciferase immunoprecipitation system assay provided serological evidence for missed diagnosis of severe fever with thrombocytopenia syndrome. Virol Sin. 2022 Feb;37(1):107-114. doi: 10.1016/j.virs.2022.01.018. Epub 2022 Jan 20. PMID: 35234635; PMCID: PMC8922417.

7: Shi J, Zhou M, Tang S, Wu Q, Deng F, Bell-Sakyi L, Shen S. Differential characteristics of mammalian and tick-derived promoters to trigger protein expression in transfected tick cell lines. Ticks Tick Borne Dis. 2022 May;13(3):101906. doi: 10.1016/j.ttbdis.2022.101906. Epub 2022 Jan 17. PMID:35114561.

8: Ren F, Shen S, Wang Q, Wei G, Huang C, Wang H, Ning YJ, Zhang DY, Deng F. Recent Advances in Bunyavirus Reverse Genetics Research: Systems Development, Applications, and Future Perspectives. Front Microbiol. 2021 Dec 7;12:771934. doi: 10.3389/fmicb.2021.771934. PMID: 34950119; PMCID: PMC8689132.

9: Liu Q, Xiong Q, Mei F, Ma C, Zhang Z, Hu B, Xu J, Jiang Y, Zhan F, Zhou S, Tao L, Chen X, Guo M, Wang X, Fang Y, Shen S, Liu Y, Liu F, Zhou L, Xu K, Ke C, Deng F, Cai K, Yan H, Chen Y, Lan K. Antibody neutralization to SARS-CoV-2 and variants after 1 year in Wuhan, China. Innovation (Camb). 2022 Jan 25;3(1):100181. doi: 10.1016/j.xinn.2021.100181. Epub 2021 Nov 3. PMID: 34746904; PMCID: PMC8563080.

10: Wang G, Huang Y, Zhang W, Peng R, Luo J, Liu S, Bai S, Hu X, Wu Z, Yang F, Shen S, Zhang Y, Tang C, Cui X, Niu L, Lu G, Li S, Deng F, Zhang P, Du J, Yin F. Identification and genome analysis of a novel picornavirus from captive belugas (Delphinapterus leucas) in China. Sci Rep. 2021 Oct 25;11(1):21018. doi: 10.1038/s41598-021-00605-y. PMID: 34697355; PMCID: PMC8549006.

11: Zhang Y, Hu B, Agwanda B, Fang Y, Wang J, Kuria S, Yang J, Masika M, Tang S, Lichoti J, Fan Z, Shi Z, Ommeh S, Wang H, Deng F, Shen S. Viromes and surveys of RNA viruses in camel-derived ticks revealing transmission patterns of novel tick-borne viral pathogens in Kenya. Emerg Microbes Infect. 2021 Dec;10(1):1975-1987. doi: 10.1080/22221751.2021.1986428. PMID: 34570681; PMCID: PMC8525980.

12: Wu J, Liang BY, Fang YH, Wang H, Yang XL, Shen S, Chen LK, Li SM, Lu SH, Xiang TD, Liu J, Le-Trilling VTK, Lu MJ, Yang DL, Deng F, Dittmer U, Trilling M, Zheng X. Occurrence of COVID-19 Symptoms During SARS-CoV-2 Infection Defines Waning of Humoral Immunity. Front Immunol. 2021 Aug 16;12:722027. doi:10.3389/fimmu.2021.722027. PMID: 34489971; PMCID: PMC8416539. 

13: Ren F, Shen S, Ning YJ, Wang Q, Dai S, Shi J, Zhou M, Wang H, Huang C, Zhang DY, Deng F. Non-structural Proteins of Severe Fever With Thrombocytopenia Syndrome Virus Suppress RNA Synthesis in a Transcriptionally Active cDNA-Derived Viral RNA Synthesis System. Front Microbiol. 2021 Aug 16;12:709517. doi:10.3389/fmicb.2021.709517. PMID: 34484148; PMCID: PMC8415556.

14: Yang Y, Csakai A, Jiang S, Smith C, Tanji H, Huang J, Jones T, Sakaniwa K,Broadwell L, Shi C, Soti S, Ohto U, Fang Y, Shen S, Deng F, Shimizu T, Yin H. Tetrasubstituted imidazoles as incognito Toll-like receptor 8？a(nta)gonists. Nat Commun. 2021 Jul 16;12(1):4351. doi: 10.1038/s41467-021-24536-4. PMID: 34272380; PMCID: PMC8285539.

15: Xiang T, Liang B, Fang Y, Lu S, Li S, Wang H, Li H, Yang X, Shen S, Zhu B, Wang B, Wu J, Liu J, Lu M, Yang D, Dittmer U, Trilling M, Deng F, Zheng X. Declining Levels of Neutralizing Antibodies Against SARS-CoV-2 in Convalescent COVID-19 Patients One Year Post Symptom Onset. Front Immunol. 2021 Jun 16;12:708523. doi: 10.3389/fimmu.2021.708523. PMID: 34220870; PMCID: PMC8242354.

16: Guo Y, Huang L, Zhang G, Yao Y, Zhou H, Shen S, Shen B, Li B, Li X, Zhang Q, Chen M, Chen D, Wu J, Fu D, Zeng X, Feng M, Pi C, Wang Y, Zhou X, Lu M, Li Y, Fang Y, Lu YY, Hu X, Wang S, Zhang W, Gao G, Adrian F, Wang Q, Yu F, Peng Y, Gabibov AG, Min J, Wang Y, Huang H, Stepanov A, Zhang W, Cai Y, Liu J, Yuan Z, Zhang C, Lou Z, Deng F, Zhang H, Shan C, Schweizer L, Sun K, Rao Z. A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes. Nat Commun. 2021 May 11;12(1):2623. doi:10.1038/s41467-021-22926-2. PMID: 33976198; PMCID: PMC8113581.

17: Fu D, Zhang G, Wang Y, Zhang Z, Hu H, Shen S, Wu J, Li B, Li X, Fang Y, Liu J, Wang Q, Zhou Y, Wang W, Li Y, Lu Z, Wang X, Nie C, Tian Y, Chen D, Wang Y, Zhou X, Wang Q, Yu F, Zhang C, Deng C, Zhou L, Guan G, Shao N, Lou Z, Deng F, Zhang H, Chen X, Wang M, Liu L, Rao Z, Guo Y. Structural basis for SARS-CoV-2 neutralizing antibodies with novel binding epitopes. PLoS Biol. 2021 May 7;19(5):e3001209. doi: 10.1371/journal.pbio.3001209. PMID: 33961621; PMCID: PMC8133496.

18: Shen S, Zhang J, Fang Y, Lu S, Wu J, Zheng X, Deng F. SARS-CoV-2 interacts with platelets and megakaryocytes via ACE2-independent mechanism. J Hematol Oncol. 2021 Apr 29;14(1):72. doi: 10.1186/s13045-021-01082-6. PMID: 33926500; PMCID: PMC8082485.

19: Wang P, Liu L, Liu A, Yan L, He Y, Shen S, Hu M, Guo Y, Liu H, Liu C, Lu Y, Wang P, Deng F, Rao Z, Lou Z. Author Correction: Structure of severe fever with thrombocytopenia syndrome virus L protein elucidates the mechanisms of viral transcription initiation. Nat Microbiol. 2021 May;6(5):697-698. doi:10.1038/s41564-021-00906-y. Erratum for: Nat Microbiol. 2020 Jun;5(6):864-871. PMID: 33883698.

20: Dai S, Wu Q, Wu X, Peng C, Liu J, Tang S, Zhang T, Deng F, Shen S. Differential Cell Line Susceptibility to Crimean-Congo Hemorrhagic Fever Virus. Front Cell Infect Microbiol. 2021 Mar 24;11:648077. doi:10.3389/fcimb.2021.648077. PMID: 33869079; PMCID: PMC8044861.

21: Wu J, Liang B, Chen C, Wang H, Fang Y, Shen S, Yang X, Wang B, Chen L, Chen Q, Wu Y, Liu J, Yang X, Li W, Zhu B, Zhou W, Wang H, Li S, Lu S, Liu D, Li H, Krawczyk A, Lu M, Yang D, Deng F, Dittmer U, Trilling M, Zheng X. SARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19. Nat Commun. 2021 Mar 22;12(1):1813. doi:10.1038/s41467-021-22034-1. PMID: 33753738; PMCID: PMC7985370.

22: Moming A, Shi S, Shen S, Qiao J, Yue X, Wang B, Ding J, Hu Z, Deng F, Zhang Y, Sun S. Fine mapping epitope on Glycoprotein-Gn from Severe Fever with Thrombocytopenia Syndrome Virus. PLoS One. 2021 Mar 2;16(3):e0248005. doi:10.1371/journal.pone.0248005. PMID: 33651850; PMCID: PMC7924767.

23: Shi J, Shen S, Wu H, Zhang Y, Deng F. Metagenomic Profiling of Viruses Associated with Rhipicephalus microplus Ticks in Yunnan Province, China. Virol Sin. 2021 Aug;36(4):623-635. doi: 10.1007/s12250-020-00319-x. Epub 2021 Jan 5. PMID: 33400089; PMCID: PMC8379324.

24: Yuan C, Wu J, Peng Y, Li Y, Shen S, Deng F, Hu Z, Zhou J, Wang M, Zou Z. Transcriptome analysis of the innate immune system of Hyalomma asiaticum. J Invertebr Pathol. 2020 Nov;177:107481. doi: 10.1016/j.jip.2020.107481. Epub 2020 Oct 6. PMID: 33035534.

25: Zohaib A, Zhang J, Saqib M, Athar MA, Hussain MH, Chen J, Sial AU, Tayyab MH, Batool M, Khan S, Luo Y, Waruhiu C, Taj Z, Hayder Z, Ahmed R, Siddique AB, Yang X, Qureshi MA, Ujjan IU, Lail A, Khan I; Sajjad-Ur-Rahman, Zhang T, Deng F, Shi Z, Shen S. Serologic Evidence of Severe Fever with Thrombocytopenia Syndrome Virus and Related Viruses in Pakistan. Emerg Infect Dis. 2020 Jul;26(7):1513-1516. doi: 10.3201/eid2607.190611. PMID: 32568060; PMCID: PMC7323538.

26: Zohaib A, Saqib M, Athar MA, Hussain MH, Sial AU, Tayyab MH, Batool M, Sadia H, Taj Z, Tahir U, Jakhrani MY, Tayyab J, Kakar MA, Shahid MF, Yaqub T, Zhang J, Wu Q, Deng F, Corman VM, Shen S, Khan I, Shi ZL. Crimean-Congo Hemorrhagic Fever Virus in Humans and Livestock, Pakistan, 2015-2017. Emerg Infect Dis. 2020 Apr;26(4):773-777. doi: 10.3201/eid2604.191154. PMID: 32187506; PMCID: PMC7101105.

27: Wu X, Li M, Zhang Y, Liang B, Shi J, Fang Y, Su Z, Li M, Zhang W, Xu L, Wang J, Wu Q, Tang S, Wang H, Zhang T, Peng C, Zheng X, Deng F, Shen S. Novel SFTSV Phylogeny Reveals New Reassortment Events and Migration Routes. Virol Sin. 2021 Apr;36(2):300-310. doi: 10.1007/s12250-020-00289-0. Epub 2020 Sep 22. PMID:32960400; PMCID: PMC8087752.

28: Tu D, Shu J, Wu X, Li H, Xia Z, Zhang Y, Fang Y, Shen S, Guan W, Wang H, Huang Z, Wang G, Zhou X, Deng F. Immunological detection of serum antibodies in pediatric medical workers exposed to varying levels of SARS-CoV-2. J Infect. 2021 Jan;82(1):159-198. doi: 10.1016/j.jinf.2020.07.023. Epub 2020 Jul 25. PMID:32721505; PMCID: PMC7382336.

29: Wang J, Liu X, Zhu Q, Wu Q, Tang S, Zhang L, Fan Z, Hu Z, Wang H, Deng F, Shen S. Identification, Isolation, and Characterization of an Ectromelia Virus New Strain from an Experimental Mouse. Virol Sin. 2021 Feb;36(1):155-158. doi: 10.1007/s12250-020-00263-w. Epub 2020 Jul 21. PMID: 32696398; PMCID: PMC7973332.

30: Wang P, Liu L, Liu A, Yan L, He Y, Shen S, Hu M, Guo Y, Liu H, Liu C, Lu Y, Wang P, Deng F, Rao Z, Lou Z. Structure of severe fever with thrombocytopenia syndrome virus L protein elucidates the mechanisms of viral transcription initiation. Nat Microbiol. 2020 Jun;5(6):864-871. doi:10.1038/s41564-020-0712-2. Epub 2020 Apr 27. Erratum in: Nat Microbiol. 2021May;6(5):697-698. PMID: 32341479.

31: Liu X, Wang H, Liu X, Li Y, Chen J, Zhang J, Wang X, Shen S, Wang H, Deng F, Wang M, Guan W, Hu Z. Genomic and transcriptional analyses of novel parvoviruses identified from dead peafowl. Virology. 2020 Jan 2;539:80-91. doi:10.1016/j.virol.2019.10.013. Epub 2019 Oct 31. PMID: 31706163.

32: Zhang J, Moming A, Yue X, Shen S, Liu D, Xu WX, Wang C, Ding J, Li Y, Deng F, Zhang Y, Sun S. Fine epitope mapping of glycoprotein Gn in Guertu virus. PLoS One. 2019 Oct 16;14(10):e0223978. doi: 10.1371/journal.pone.0223978. PMID:31618247; PMCID: PMC6795428.

33: Zhu L, Yin F, Moming A, Zhang J, Wang B, Gao L, Ruan J, Wu Q, Wu N, Wang H, Deng F, Lu G, Shen S. First case of laboratory-confirmed severe fever with thrombocytopenia syndrome disease revealed the risk of SFTSV infection in Xinjiang, China. Emerg Microbes Infect. 2019;8(1):1122-1125. doi:10.1080/22221751.2019.1645573. PMID: 31347462; PMCID: PMC6711166.

34: Li S, Wang Y, Hou D, Guan Z, Shen S, Peng K, Deng F, Chen X, Hu Z, Wang H, Wang M. Host factor heat-shock protein 90 contributes to baculovirus budded virus morphogenesis via facilitating nuclear actin polymerization. Virology. 2019 Sep;535:200-209. doi: 10.1016/j.virol.2019.07.006. Epub 2019 Jul 5. PMID:31319277.

35: Li LL, Liu MM, Shen S, Zhang YJ, Xu YL, Deng HY, Deng F, Duan ZJ. Detection and characterization of a novel hepacivirus in long-tailed ground squirrels (Spermophilus undulatus) in China. Arch Virol. 2019 Sep;164(9):2401-2410. doi:10.1007/s00705-019-04303-z. Epub 2019 Jun 18. PMID: 31243554.

36: Abudurexiti A, Adkins S, Alioto D, Alkhovsky SV, Av？i？-？upanc T, Ballinger MJ, Bente DA, Beer M, Bergeron é, Blair CD, Briese T, Buchmeier MJ, Burt FJ, Calisher CH, Cháng C, Charrel RN, Choi IR, Clegg JCS, de la Torre JC, de Lamballerie X, Dèng F, Di Serio F, Digiaro M, Drebot MA, Duàn X, Ebihara H, Elbeaino T, Ergünay K, Fulhorst CF, Garrison AR, Gāo GF, Gonzalez JJ, Groschup MH, Günther S, Haenni AL, Hall RA, Hepojoki J, Hewson R, Hú Z, Hughes HR, Jonson MG, Junglen S, Klempa B, Klingstr？m J, Kòu C, Laenen L, Lambert AJ, Langevin SA, Liu D, Lukashevich IS, LuòT, LǚC, Maes P, de Souza WM, Marklewitz M, Martelli GP, Matsuno K, Mielke-Ehret N, Minutolo M, Mirazimi A, Moming A, Mühlbach HP, Naidu R, Navarro B, Nunes MRT, Palacios G, Papa A, Pauvolid-Corrêa A, Paw？ska JT, Qiáo J, Radoshitzky SR, Resende RO, Romanowski V, Sall AA, Salvato MS, Sasaya T, Shěn S, Shí X, Shirako Y, Simmonds P, Sironi M, Song JW, Spengler JR, Stenglein MD, Sū Z, Sūn S, Táng S, Turina M, Wáng B, Wáng C, Wáng H, Wáng J, Wèi T, Whitfield AE, Zerbini FM, Zhāng J, Zhāng L, Zhāng Y, Zhang YZ, Zhāng Y, Zhou X, Zhū L, Kuhn JH. Taxonomy of the order Bunyavirales: update 2019. Arch Virol. 2019 Jul;164(7):1949-1965. doi: 10.1007/s00705-019-04253-6. Epub 2019 May 7. PMID: 31065850; PMCID: PMC6641860.

37: Zhang LK, Wang B, Xin Q, Shang W, Shen S, Xiao G, Deng F, Wang H, Hu Z, Wang M. Quantitative Proteomic Analysis Reveals Unfolded-Protein Response Involved in Severe Fever with Thrombocytopenia Syndrome Virus Infection. J Virol. 2019 May 1;93(10):e00308-19. doi: 10.1128/JVI.00308-19. PMID: 30842332; PMCID:PMC6498065.

38: Shen S, Duan X, Wang B, Zhu L, Zhang Y, Zhang J, Wang J, Luo T, Kou C, Liu D, Lv C, Zhang L, Chang C, Su Z, Tang S, Qiao J, Moming A, Wang C, Abudurexiti A, Wang H, Hu Z, Zhang Y, Sun S, Deng F. A novel tick-borne phlebovirus, closely related to severe fever with thrombocytopenia syndrome virus and Heartland virus, is a potential pathogen. Emerg Microbes Infect. 2018 May 25;7(1):95. doi:10.1038/s41426-018-0093-2. PMID: 29802259; PMCID: PMC5970217.

39: Li Y, Shen S, Hu L, Deng F, Vlak JM, Hu Z, Wang H, Wang M. The Functional Oligomeric State of Tegument Protein GP41 Is Essential for Baculovirus Budded Virion and Occlusion-Derived Virion Assembly. J Virol. 2018 May 29;92(12):e02083-17. doi: 10.1128/JVI.02083-17. PMID: 29643237; PMCID:PMC5974493.

40: Shi J, Hu Z, Deng F, Shen S. Tick-Borne Viruses. Virol Sin. 2018 Feb;33(1):21-43. doi: 10.1007/s12250-018-0019-0. Epub 2018 Mar 13. PMID:29536246; PMCID: PMC5866268.

41: Moming A, Yue X, Shen S, Chang C, Wang C, Luo T, Zhang Y, Guo R, Hu Z, Zhang Y, Deng F, Sun S. Prevalence and Phylogenetic Analysis of Crimean-Congo Hemorrhagic Fever Virus in Ticks from Different Ecosystems in Xinjiang, China. Virol Sin. 2018 Feb;33(1):67-73. doi: 10.1007/s12250-018-0016-3. Epub 2018 Mar 9. PMID: 29524182; PMCID: PMC6178079.

42: Zhang Y, Shen S, Fang Y, Liu J, Su Z, Liang J, Zhang Z, Wu Q, Wang C, Abudurexiti A, Hu Z, Zhang Y, Deng F. Isolation, Characterization, and Phylogenetic Analysis of Two New Crimean-Congo Hemorrhagic Fever Virus Strains from the Northern Region of Xinjiang Province, China. Virol Sin. 2018 Feb;33(1):74-86. doi: 10.1007/s12250-018-0020-7. Epub 2018 Mar 8. PMID:29520745; PMCID: PMC6178084.

43: Wang J, Hou D, Wang Q, Kuang W, Zhang L, Li J, Shen S, Deng F, Wang H, Hu Z, Wang M. Genome analysis of a novel Group I alphabaculovirus obtained from Oxyplax ochracea. PLoS One. 2018 Feb 1;13(2):e0192279. doi:10.1371/journal.pone.0192279. PMID: 29390020; PMCID: PMC5794183.