邓增钦

研究方向

主要利用结构生物学、生物化学、细胞生物学和病毒学等研究手段揭示病毒感染过程中关键蛋白复合物的生化功能和分子机制。

教育及工作经历

2005.9-2009.7, 中国农业大学, 生物科学, 学士

2009.9-2014.7, 中国农业大学, 生物化学与分子生物学, 博士

2014.9-2019.8, Washington University in St. Louis, 博士后

2019.9-2021.2, Washington University in St. Louis, 讲师

2021.3-现在,   中国科学院武汉病毒研究所,研究员

近五年承担项目

1.国家自然科学基金青年项目，2023/1-2025/12，在研，主持

2.中科院引才计划择优支持项目，2022/1-2024/12，在研，主持

3.武汉市知识创新专项项目，2022/6-2024/6，在研，主持

3.国家重点研发计划重点专项，2023/1-2025/12，在研，骨干

4.国家重点研发计划重点专项，2023/1-2027/12，在研，骨干

近五年代表性论文

1. Kuang, Wenhua#*; Zhao, Yan#; Li, Jinyue; Deng, Zengqin*; Structure-function analysis of the ATPase domain of African swine fever virus topoisomerase, mBio, 2024，e0308623.   

2. Zhao, Yan#; Kuang, Wenhua#*; An, Qiyin; Li, Jinyue; Wang, Yong; Deng, Zengqin*; Cryo-EM structures of African swine fever virus topoisomerase, mBio, 2023, e0122823.

3. Yang, Shangyu#; Wang, Yong#; Yu, Feiyang#; Cheng, Rao; Zhang, Yiwei; Zhou, Dan; Ren, Xuanxiu; Deng, Zengqin*; Zhao, Haiyan*; Structural and functional insights into the modulation of T cell costimulation by monkeypox virus protein M2, Nature Communications, 2023, 14 (1) :5186.  

4. Wang, Xiaoshen#; Li, Xuzichao#; Yu, Guimei#; Zhang, Lingling#; Zhang, Chendi#; Wang, Yong#; Liao, Fumeng; Wen, Yanan; Yin, Hang; Liu, Xiang; Wei, Yong; Li, Zhuang*; Deng, Zengqin*; Zhang, Heng*; Structural insights into mechanisms of Argonaute protein-associated NADase activation in bacterial immunity, Cell Research, 2023, 0: 1-13.  

5. Yu, Guimei#; Wang, Xiaoshen#; Zhang, Yi#; An, Qiyin#; Wen, Yanan; Li, Xuzichao; Yin, Hang; Deng, Zengqin*; Zhang, Heng*; Structure and function of a bacterial type III-E CRISPR–Cas7-11 complex, Nature Microbiology, 2022, 7(12): 2078-2088. 

6. Wang, Xiaoshen#; Yu, Guimei#; Wen, Yanan#; An, Qiyin#; Li, Xuzichao; Liao, Fumeng; Lian, Chengwei; Zhang, Kai; Yin, Hang; Wei, Yong; Deng, Zengqin*; Zhang, Heng*; Target RNA-guided protease activity in type III-E CRISPR–Cas system, Nucleic Acids Research, 2022, 50(22): 12913-12923.   

7. Deng, Zengqin; Zhao, Yonghui; Feng, Jing; Zhang, Jingying; Zhao, Haiyan; Rau, Michael J.; Fitzpatrick, James A. J.; Hu, Hongzhen; Yuan, Peng*; Cryo-EM structure of a proton-activated chloride channel TMEM206, Science Advances, 2021, 7(9): eabe5983.         

8. Deng, Zengqin#; He, Zhihui#; Maksaev, Grigory; Bitter, Ryan M.; Rau, Michael; Fitzpatrick, James A. J.; Yuan, Peng*; Cryo-EM structures of the ATP release channel pannexin 1, Nature Structural & Molecular Biology, 2020, 27(4): 373-381.      

9. Deng, Zengqin#; Maksaev, Grigory#; Rau, Michael; Xie, Zili; Hu, Hongzhen; Fitzpatrick, James A. J.; Yuan, Peng*; Gating of human TRPV3 in a lipid bilayer, Nature Structural & Molecular Biology, 2020, 27(7): 635-644.     

10. Deng, Zengqin; Maksaev, Grigory; Schlegel, Angela M.; Zhang, Jingying; Rau, Michael; Fitzpatrick, James A. J.; Haswell, Elizabeth S.; Yuan, Peng*; Structural mechanism for gating of a eukaryotic mechanosensitive channel of small conductance, Nature Communications, 2020, 11(1): 3690.      

11. Deng, Zengqin; Paknejad, Navid; Maksaev, Grigory; Sala, Rabanal Monica; Nichols, Colin G.; Hite, Richard K.*; Yuan, Peng*, Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms, Nature Structural & Molecular Biology, 2018, 25(3): 252-260.