邓增钦

研究方向

课题组主要利用生物化学、生物物理学以及病毒学等手段从事以下研究：1）病原微生物关键酶的催化机制研究；2）病毒-宿主互作的分子机制研究；3）传染病防治手段研发。

教育及工作经历

2021.03-至今，中国科学院武汉病毒研究所，研究员

2019.09-2021.02，Washington University in St. Louis，讲师

2014.09-2019.08，Washington University in St. Louis，博士后

2009.09-2014.07，中国农业大学，博士

2005.09-2009.07，中国农业大学，学士

近五年承担项目

1. 国家自然科学基金面上项目，主持，项目名称：KSHV核糖核苷酸还原酶的酶活性调控及其拮抗宿主限制因子的结构生物学研究

2. 国家自然科学基金青年科学基金项目，主持，项目名称：蜱传布尼亚病毒SFTSV和CCHFV核糖核蛋白体形成的结构基础与分子机制

3. 国家重点研发计划项目，骨干，项目名称：高致病性出血热致病机制和干预策略

4. 国家重点研发计划项目，骨干，项目名称：结核杆菌感染和宿主抗感染免疫过程中的关键生物大分子鉴定、调控机制和应用研究

5. 湖北省青年A类项目，主持

近五年代表性论文

1. Jie Han#, Bin Liu#, Jingjing Tang#, Shuqin Zhang#, Xiaoshen Wang, Xuzichao Li, Qian Zhang, Zhikun Liu, Wanyao Wang, Yingcan Liu, Ruimin Zhou, Hang Yin, Yong Wei, Zhuang Li, Minjie Zhang*, Zengqin Deng*, and Heng Zhang*；Non-coding RNA mediates the defense-associated reverse transcriptase (DRT) anti-phage oligomerization transition；EMBO J，2025

2. Cheng-Bao Ma#, Chen Liu#, Young-Jun Park#, Jingjing Tang#, Jing Chen#, Qing Xiong, Jimin Lee, Cameron Stewart, Daniel Asarnow, Jack Brown, M Alejandra Tortorici, Xiao Yang, Ye-Hui Sun, Yuan-Mei Chen, Xiao Yu, Jun-Yu Si, Peng Liu, Fei Tong, Mei-Ling Huang, Jing Li, Zheng-Li Shi*, Zengqin Deng*, David Veesler*, Huan Yan*; Multiple independent acquisitions of ACE2 usage in MERS-related coronaviruses; Cell, 2025, 188(6):1693-1710

3. Qiyin An#, Yong Wang#, Zhenhua Tian#, Jie Han#, Jinyue Li, Fumeng Liao, Feiyang Yu, Haiyan Zhao, Yancheng Wen, Heng Zhang, Zengqin Deng*;   Molecular and structural basis of an ATPase-nuclease dual-enzyme anti-phage defense complex; Cell Research, 2024, 34(8):545-555

4. Jie Yang#, Xuzichao Li#, Qiuqiu He#, Xiaoshen Wang#, Jingjing Tang#, Tongyao Wang#, Yi Zhang, Feiyang Yu, Shuqin Zhang, Zhikun Liu, Lingling Zhang, Fumeng Liao, Hang Yin, Haiyan Zhao, Zengqin Deng*, Heng Zhang*; Structural basis for the activity of the type VII CRISPR-Cas system; Nature, 2024, 633(8029):465-472

5. Xuanxiu Ren#, Jiawen Sun#, Wenhua Kuang#, Feiyang Yu, Bingjie Wang, Yong Wang, Wei Deng, Zhao Xu, Shangyu Yang, Hualin Wang, Yangbo Hu, Zengqin Deng*, Yun-Jia Ning*, Haiyan Zhao*; A broadly protective antibody targeting glycoprotein Gn inhibits severe fever with thrombocytopenia syndrome virus   infection, Nature Communications, 2024, 15(1):7009

6. Wenhua Kuang#*, Yan Zhao#, Jinyue Li, Zengqin Deng*; Structure-function analysis of the ATPase domain of African swine fever virus topoisomerase；mBio, 2024, 15(4):e0308623

7. Dan Zhou#, Rao Cheng#, Yanfeng Yao#, Gan Zhang, Xin Li, Bingjie Wang, Yong Wang, Feiyang Yu, Shangyu Yang, Hang Liu, Ge Gao, Yun Peng, Miaoyu Chen, Zengqin Deng*, Haiyan Zhao*; An attachment glycoprotein nanoparticle elicits broadly neutralizing antibodies and protects against lethal Nipah virus infection; npj Vaccines, 2024, 9(1):1581

8. Yan Zhao#, Wenhua Kuang#*, Qiyin An, Jinyue Li, Yong Wang, Zengqin Deng*; Cryo-EM structures of African swine fever virus topoisomerase; mBio, 2023, 14(5):e0122823

9. Shangyu Yang#, Yong Wang#, Feiyang Yu#, Rao Cheng, Yiwei Zhang, Dan Zhou, Xuanxiu Ren, Zengqin Deng*, Haiyan Zhao*; Structural and functional insights into the modulation of T cell costimulation by monkeypox virus protein M2; Nature Communications, 2023, 14(1):5186

10. Xiaoshen Wang#, Xuzichao Li#, Guimei Yu#, Lingling Zhang#, Chendi Zhang#, Yong Wang#, Fumeng Liao, Yanan Wen, Hang Yin, Xiang Liu, Yong Wei, Zhuang Li*, Zengqin Deng*, Heng Zhang*; Structural insights into mechanisms of Argonaute protein-associated NADase activation in bacterial immunity; Cell   Research, 2023, 33(9):699-711

11. Guimei Yu#, Xiaoshen Wang#, Yi Zhang#, Qiyin An#, Yanan Wen, Xuzichao Li, Hang Yin, Zengqin Deng*, Heng Zhang*; Structure and function of a bacterial type III-E CRISPR–Cas7-11 complex；Nature Microbiology, 2022, 7(12):2078-2088

12. Xiaoshen Wang#, Guimei Yu#, Yanan Wen#, Qiyin An#, Xuzichao Li, Fumeng Liao, Chengwei Lian, Kai Zhang, Hang Yin, Yong Wei, Zengqin Deng*, Heng Zhang*; Target RNA-guided protease activity in type III-E CRISPR–Cas system；Nucleic Acids Research, 2022, 50(22):12913-12923