王华林

姓名：王华林

职称职务：研究员

电子邮箱：h.wang@wh.iov.cn

研究方向

1.研究病毒与宿主相互作用

2.研究病毒侵染机理及致病的分子机制

3.构建抗病毒药物及新基因筛选等基因工程技术平台

4.溶瘤病毒、新疫苗、抗病毒药物及诊断试剂和方法

教育及工作经历

1992.9-1997.7复旦大学微生物学专业，学士，其中1992.9-1993.7 在大连陆军学院军事训练一年；

1997.9-2000.7中国科学院武汉病毒研究所微生物学专业，硕士；

2000.7-2003.12中国科学院水生生物研究所遗传学专业，博士；

2000.8-2001.4获荷兰NUFFIC 奖学金资助在Wageningen 大学开展Sandwich-PhD访问研究；

2001.5-2003.4获德国DAAD 奖学金资助，在德国Staatliche Lehr-Und ForschungsAnstalt，Neustadt/Weinstrasse（SLFA）研究所开展Sandwich-PhD 访问研究；

2001.5-2003.4德国SLFA 研究所，Sandwich-PhD 访问学者；

2000.8-2001.4荷兰Wageningen 大学，Sandwich-PhD 访问学者；

2000.7-2002.8中国科学院武汉病毒研究所，助理研究员；

2002.9-2007.8中国科学院武汉病毒研究所，副研究员；

2007.9-至今中国科学院武汉病毒研究所，研究员。

近五年承担项目

1.科技部，国家重点研发计划重点专项，生物安全关键技术研发，2743万元，在研，主持

2.科技部，国家重点研发计划重点专项，高致病性病毒转录复制过程关键蛋白质机器的功能及调控机制，168.43万元，在研，参与

3.国家自然科学基金委员会，病毒感染及入侵机制的研究，80万元，在研，主持

4.国家自然科学基金委员会，国家自然科学基金委创新研究群体科学基金延续项目，病毒与宿主相互作用的分子机理，100万元，已结题，主持

5.国家自然科学基金委员会，国家杰出青年科学基金项目，病毒膜融合蛋白研究，200万元，已结题，主持

6.中国科学院，中国科学院重点部署项目，快速检测技术和产品研发，275万元，已结题，参与

近五年代表性论文

1.Chen T,Duan X,Hu H,Shang Y,Hu Y,Deng F,Wang H,Wang M,Hu Z. Systematic Analysis of 42 Autographa Californica Multiple Nucleopolyhedrovirus Genes Identifies An Additional Six Genes Involved in the Production of Infectious Budded Virus. Virol Sin. 2021 Mar 8. doi: 10.1007/s12250-021-00355-1. Epub ahead of print. PMID: 33683665.

2.He L,Shao W,Li J,Deng F,Wang H,Hu Z,Wang M. Systematic analysis of nuclear localization of Autographa californica multiple nucleopolyhedrovirus proteins. J Gen Virol. 2021 Jan 18. doi: 10.1099/jgv.0.001517. Epub ahead of print. PMID: 33459587.

3.Mo Q,Xu Z,Deng F,Wang H,Ning YJ. Host restriction of emerging high-pathogenic bunyaviruses via MOV10 by targeting viral nucleoprotein and blocking ribonucleoprotein assembly. PLoS Pathog. 2020 Dec 7;16(12):e1009129. doi: 10.1371/journal.ppat.1009129. PMID: 33284835;PMCID:PMC7746268.

4.Min YQ,Mo Q,Wang J,Deng F,Wang H,Ning YJ. SARS-CoV-2 nsp1: Bioinformatics,Potential Structural and Functional Features,and Implications for Drug/Vaccine Designs. Front Microbiol. 2020 Sep 29;11:587317. doi: 10.3389/fmicb.2020.587317. PMID: 33133055;PMCID:PMC7550470.

5.Wu X,Li M,Zhang Y,Liang B,Shi J,Fang Y,Su Z,Li M,Zhang W,Xu L,Wang J,Wu Q,Tang S,Wang H,Zhang T,Peng C,Zheng X,Deng F,Shen S. Novel SFTSV Phylogeny Reveals New Reassortment Events and Migration Routes. Virol Sin. 2020 Sep 22. doi: 10.1007/s12250-020-00289-0. Epub ahead of print. PMID: 32960400.

6.Tu D,Shu J,Wu X,Li H,Xia Z,Zhang Y,Fang Y,Shen S,Guan W,Wang H,Huang Z,Wang G,Zhou X,Deng F. Immunological detection of serum antibodies in pediatric medical workers exposed to varying levels of SARS-CoV-2. J Infect. 2021 Jan;82(1):159-198. doi: 10.1016/j.jinf.2020.07.023. Epub 2020 Jul 25. PMID: 32721505;PMCID:PMC7382336.

7.Wang J,Liu X,Zhu Q,Wu Q,Tang S,Zhang L,Fan Z,Hu Z,Wang H,Deng F,Shen S. Identification,Isolation,and Characterization of an Ectromelia Virus New Strain from an Experimental Mouse. Virol Sin. 2020 Jul 21. doi: 10.1007/s12250-020-00263-w. Epub ahead of print. PMID: 32696398.

8.Min YQ,Ning YJ,Wang H,Deng F. A RIG-I-like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination. J Biol Chem. 2020 Jul 10;295(28):9691-9711. doi: 10.1074/jbc.RA120.013973. Epub 2020 May 29. PMID: 32471869;PMCID:PMC7363118.

9.Zhang H,Kuang W,Chen C,Shang Y,Ma X,Deng F,Wang H,Wang M,Hu Z. Per Os Infectivity Factor 5 Identified as a Substrate of P33 in the Baculoviral Disulfide Bond Formation Pathway. J Virol. 2020 Jul 16;94(15):e00615-20. doi: 10.1128/JVI.00615-20. PMID: 32434885;PMCID:PMC7375385.

10.Ren F,Zhou M,Deng F,Wang H,Ning YJ. Combinatorial Minigenome Systems for Emerging Banyangviruses Reveal Viral Reassortment Potential and Importance of a Protruding Nucleotide in Genome"Panhandle"for Promoter Activity and Reassortment. Front Microbiol. 2020 Apr 8;11:599. doi: 10.3389/fmicb.2020.00599. PMID: 32322247;PMCID:PMC7156889.

11.Min YQ,Shi C,Yao T,Feng K,Mo Q,Deng F,Wang H,Ning YJ. The Nonstructural Protein of Guertu Virus Disrupts Host Defenses by Blocking Antiviral Interferon Induction and Action. ACS Infect Dis. 2020 May 8;6(5):857-870. doi: 10.1021/acsinfecdis.9b00492. Epub 2020 Mar 20. PMID: 32167734.

12.Li Y,Hu L,Chen T,Chang M,Deng F,Hu Z,Wang H,Wang M. Host AAA+ ATPase TER94 Plays Critical Roles in Building the Baculovirus Viral Replication Factory and Virion Morphogenesis. J Virol. 2020 Feb 28;94(6):e01674-19. doi: 10.1128/JVI.01674-19. PMID: 31896597;PMCID:PMC7158741.

13.Liu X,Wang H,Liu X,Li Y,Chen J,Zhang J,Wang X,Shen S,Wang H,Deng F,Wang M,Guan W,Hu Z. Genomic and transcriptional analyses of novel parvoviruses identified from dead peafowl. Virology. 2020 Jan 2;539:80-91. doi: 10.1016/j.virol.2019.10.013. Epub 2019 Oct 31. PMID: 31706163.

14.Li J,Duan X,Wang Q,Zhang L,Deng F,Wang H,Hu Z,Wang M,Wang J. Genome Analysis of a Novel Clade II.b Alphabaculovirus Obtained from Artaxa digramma. Viruses. 2019 Oct 9;11(10):925. doi: 10.3390/v11100925. PMID: 31601038;PMCID:PMC6832367.

15.Hou D,Kuang W,Luo S,Zhang F,Zhou F,Chen T,Zhang Y,Wang H,Hu Z,Deng F,Wang M. Baculovirus ODV-E66 degrades larval peritrophic membrane to facilitate baculovirus oral infection. Virology. 2019 Nov;537:157-164. doi: 10.1016/j.virol.2019.08.027. Epub 2019 Aug 29. PMID: 31493654.

16.Zhu L,Yin F,Moming A,Zhang J,Wang B,Gao L,Ruan J,Wu Q,Wu N,Wang H,Deng F,Lu G,Shen S. First case of laboratory-confirmed severe fever with thrombocytopenia syndrome disease revealed the risk of SFTSV infection in Xinjiang,China. Emerg Microbes Infect. 2019;8(1):1122-1125. doi: 10.1080/22221751.2019.1645573. PMID: 31347462;PMCID:PMC6711166.

17.Li S,Wang Y,Hou D,Guan Z,Shen S,Peng K,Deng F,Chen X,Hu Z,Wang H,Wang M. Host factor heat-shock protein 90 contributes to baculovirus budded virus morphogenesis via facilitating nuclear actin polymerization. Virology. 2019 Sep;535:200-209. doi: 10.1016/j.virol.2019.07.006. Epub 2019 Jul 5. PMID: 31319277.

18.Shao W,He L,Chen Q,Li J,Deng F,Wang H,Hu Z,Wang M. Functional Characterization of the Group I Alphabaculovirus Specific Gene ac73. Virol Sin. 2019 Dec;34(6):701-711. doi: 10.1007/s12250-019-00146-9. Epub 2019 Jul 17. PMID: 31317397;PMCID:PMC6888964.

19.Zhou F,Kuang W,Wang X,Hou D,Huang H,Sun X,Deng F,Wang H,van Oers MM,Wang M,Hu Z. The cysteine-rich region of a baculovirus VP91 protein contributes to the morphogenesis of occlusion bodies. Virology. 2019 Sep;535:144-153. doi: 10.1016/j.virol.2019.06.016. Epub 2019 Jul 3. PMID: 31302508.

20.Hu L,Li Y,Deng F,Hu Z,Wang H,Wang M. Improving Baculovirus Transduction of Mammalian Cells by Incorporation of Thogotovirus Glycoproteins. Virol Sin. 2019 Aug;34(4):454-466. doi: 10.1007/s12250-019-00133-0. Epub 2019 Jun 14. PMID: 31201733;PMCID:PMC6687793.

21.Ning YJ,Mo Q,Feng K,Min YQ,Li M,Hou D,Peng C,Zheng X,Deng F,Hu Z,Wang H. Interferon-γ-Directed Inhibition of a Novel High-Pathogenic Phlebovirus and Viral Antagonism of the Antiviral Signaling by Targeting STAT1. Front Immunol. 2019 May 28;10:1182. doi: 10.3389/fimmu.2019.01182. PMID: 31191546;PMCID:PMC6546826.

22.Hu L,Li Y,Ning YJ,Deng F,Vlak JM,Hu Z,Wang H,Wang M. The Major Hurdle for Effective Baculovirus Transduction into Mammalian Cells Is Passing Early Endosomes. J Virol. 2019 Jul 17;93(15):e00709-19. doi: 10.1128/JVI.00709-19. PMID: 31092570;PMCID:PMC6639295.

23. Abudurexiti A,Adkins S,Alioto D,Alkhovsky SV,Av?i?-?upanc T,Ballinger MJ,Bente DA,Beer M,Bergeron é,Blair CD,Briese T,Buchmeier MJ,Burt FJ,Calisher CH,Cháng C,Charrel RN,Choi IR,Clegg JCS,de la TorreJC,de Lamballerie X,Dèng F,Di Serio F,Digiaro M,Drebot MA,Duàn X,Ebihara H,Elbeaino T,Ergünay K,Fulhorst CF,Garrison AR,Gāo GF,Gonzalez JJ,Groschup MH,Günther S,Haenni AL,Hall RA,Hepojoki J,Hewson R,Hú Z,Hughes HR,Jonson MG,Junglen S,Klempa B,Klingstr?m J,Kòu C,Laenen L,Lambert AJ,Langevin SA,Liu D,Lukashevich IS,Luò T,Lǚ C,Maes P,de Souza WM,Marklewitz M,Martelli GP,Matsuno K,Mielke-Ehret N,Minutolo M,Mirazimi A,Moming A,Mühlbach HP,Naidu R,Navarro B,Nunes MRT,Palacios G,Papa A,Pauvolid-Corrêa A,Paw?ska JT,Qiáo J,Radoshitzky SR,Resende RO,Romanowski V,Sall AA,Salvato MS,Sasaya T,Shěn S,Shí X,Shirako Y,Simmonds P,Sironi M,Song JW,Spengler JR,Stenglein MD,Sū Z,Sūn S,Táng S,Turina M,Wáng B,Wáng C,Wáng H,Wáng J,Wèi T,Whitfield AE,Zerbini FM,Zhāng J,Zhāng L,Zhāng Y,Zhang YZ,Zhāng Y,Zhou X,Zhū L,Kuhn JH. Taxonomy of the order Bunyavirales: update 2019. Arch Virol. 2019 Jul;164(7):1949-1965. doi: 10.1007/s00705-019-04253-6. Epub 2019 May 7. PMID: 31065850;PMCID:PMC6641860.

24.Feng K,Deng F,Hu Z,Wang H,Ning YJ. Heartland virus antagonizes type I and III interferon antiviral signaling by inhibiting phosphorylation and nuclear translocation of STAT2 and STAT1. J Biol Chem. 2019 Jun 14;294(24):9503-9517. doi: 10.1074/jbc.RA118.006563. Epub 2019 Apr 30. PMID: 31040183;PMCID:PMC6579454.

25.Zhang LK,Wang B,Xin Q,Shang W,Shen S,Xiao G,Deng F,Wang H,Hu Z,Wang M. Quantitative Proteomic Analysis Reveals Unfolded-Protein Response Involved in Severe Fever with Thrombocytopenia Syndrome Virus Infection. J Virol. 2019 May 1;93(10):e00308-19. doi: 10.1128/JVI.00308-19. PMID: 30842332;PMCID:PMC6498065.

26.Wang X,Shang Y,Chen C,Liu S,Chang M,Zhang N,Hu H,Zhang F,Zhang T,Wang Z,Liu X,Lin Z,Deng F,Wang H,Zou Z,Vlak JM,Wang M,Hu Z. Baculovirus Per Os Infectivity Factor Complex: Components and Assembly. J Virol. 2019 Mar 5;93(6):e02053-18. doi: 10.1128/JVI.02053-18. PMID: 30602603;PMCID:PMC6401453.

27.Liu J,Xu M,Tang B,Hu L,Deng F,Wang H,Pang DW,Hu Z,Wang M,Zhou Y. Single-Particle Tracking Reveals the Sequential Entry Process of the Bunyavirus Severe Fever with Thrombocytopenia Syndrome Virus. Small. 2019 Feb;15(6):e1803788. doi: 10.1002/smll.201803788. Epub 2018 Dec 27. PMID: 30589216.

28.Zhu Z,Wang J,Wang Q,Yin F,Liu X,Hou D,Zhang L,Liu H,Li J,Arif BM,Wang H,Deng F,Hu Z,Wang M. Genome Characteristics of the Cyclophragma Undans Nucleopolyhedrovirus: A Distinct Species in Group I of Alphabaculovirus. Virol Sin. 2018 Aug;33(4):359-368. doi: 10.1007/s12250-018-0047-9. Epub 2018 Aug 28. PMID: 30155853;PMCID:PMC6178095.

29.Dai S,Zhang Y,Zhang T,Zhang B,Wang H,Deng F. Establishment of Baculovirus-Expressed VLPs Induced Syncytial Formation Assay for Flavivirus Antiviral Screening. Viruses. 2018 Jul 11;10(7):365. doi: 10.3390/v10070365. PMID: 29997331;PMCID:PMC6071280.

30.Shen S,Duan X,Wang B,Zhu L,Zhang Y,Zhang J,Wang J,Luo T,Kou C,Liu D,Lv C,Zhang L,Chang C,Su Z,Tang S,Qiao J,Moming A,Wang C,Abudurexiti A,Wang H,Hu Z,Zhang Y,Sun S,Deng F. A novel tick-borne phlebovirus,closely related to severe fever with thrombocytopenia syndrome virus and Heartland virus,is a potential pathogen. Emerg Microbes Infect. 2018 May 25;7(1):95. doi: 10.1038/s41426-018-0093-2. PMID: 29802259;PMCID:PMC5970217.

31.Dai S,Zhang T,Zhang Y,Wang H,Deng F. Zika Virus Baculovirus-Expressed Virus-Like Particles Induce Neutralizing Antibodies in Mice. Virol Sin. 2018 Jun;33(3):213-226. doi: 10.1007/s12250-018-0030-5. Epub 2018 May 17. PMID: 29774519;PMCID:PMC6013542.

32.Li Y,Shen S,Hu L,Deng F,Vlak JM,Hu Z,Wang H,Wang M. The Functional Oligomeric State of Tegument Protein GP41 Is Essential for Baculovirus Budded Virion and Occlusion-Derived Virion Assembly. J Virol. 2018 May 29;92(12):e02083-17. doi: 10.1128/JVI.02083-17. PMID: 29643237;PMCID:PMC5974493.

33.Makalliwa GA,Wang X,Zhang H,Zhang N,Chen C,Li J,Deng F,Wang H,Wang M,Hu Z. HearNPV Pseudotyped with PIF1,2,and 3 from MabrNPV: Infectivity and Complex Stability. Virol Sin. 2018 Apr;33(2):187-196. doi: 10.1007/s12250-018-0014-5. Epub 2018 Mar 16. PMID: 29549650;PMCID:PMC6178116.

34.Li Y,Ni L,Chen J,Yang J,Deng F,Wang H. Development of Multi-analyte Suspension Assay for Simultaneously Efficient Detection of Avian Influenza Virus A Subtypes. Virol Sin. 2018 Feb;33(1):111-115. doi: 10.1007/s12250-018-0018-1. Epub 2018 Mar 2. PMID: 29500693;PMCID:PMC6178083.

35.Wang X,Chen C,Zhang N,Li J,Deng F,Wang H,Vlak JM,Hu Z,Wang M. The group I alphabaculovirus-specific protein,AC5,is a novel component of the occlusion body but is not associated with ODVs or the PIF complex. J Gen Virol. 2018 Apr;99(4):585-595. doi: 10.1099/jgv.0.001031. Epub 2018 Feb 21. PMID: 29465345.

36.Wang J,Hou D,Wang Q,Kuang W,Zhang L,Li J,Shen S,Deng F,Wang H,Hu Z,Wang M. Genome analysis of a novel Group I alphabaculovirus obtained from Oxyplax ochracea. PLoS One. 2018 Feb 1;13(2):e0192279. doi: 10.1371/journal.pone.0192279. PMID: 29390020;PMCID:PMC5794183.

37.Du R,Wang L,Xu H,Wang Z,Zhang T,Wang M,Ning Y,Deng F,Hu Z,Wang H,Li Y. A novel glycoprotein D-specific monoclonal antibody neutralizes herpes simplex virus. Antiviral Res. 2017 Nov;147:131-141. doi: 10.1016/j.antiviral.2017.10.013. Epub 2017 Oct 20. PMID: 29061442;PMCID:PMC7113901.

38.Ning YJ,Kang Z,Xing J,Min YQ,Liu D,Feng K,Wang M,Deng F,Zhou Y,Hu Z,Wang H. Ebola virus mucin-like glycoprotein (Emuc) induces remarkable acute inflammation and tissue injury: evidence for Emuc pathogenicity in vivo. Protein Cell. 2018 Apr;9(4):389-393. doi: 10.1007/s13238-017-0471-x. PMID: 28956289;PMCID:PMC5876185.

39.Kuang W,Zhang H,Wang M,Zhou NY,Deng F,Wang H,Gong P,Hu Z. Three Conserved Regions in Baculovirus Sulfhydryl Oxidase P33 Are Critical for Enzymatic Activity and Function. J Virol. 2017 Nov 14;91(23):e01158-17. doi: 10.1128/JVI.01158-17. PMID: 28904203;PMCID:PMC5686738.

40.Ning YJ,Feng K,Min YQ,Deng F,Hu Z,Wang H. Heartland virus NSs protein disrupts host defenses by blocking the TBK1 kinase-IRF3 transcription factor interaction and signaling required for interferon induction. J Biol Chem. 2017 Oct 6;292(40):16722-16733. doi: 10.1074/jbc.M117.805127. Epub 2017 Aug 28. PMID: 28848048;PMCID:PMC5633133.

41.Wang X,Liu X,Makalliwa GA,Li J,Wang H,Hu Z,Wang M. Per os infectivity factors: a complicated and evolutionarily conserved entry machinery of baculovirus. Sci China Life Sci. 2017 Aug;60(8):806-815. doi: 10.1007/s11427-017-9127-1. Epub 2017 Jul 27. PMID: 28755302.

42.Wang M,Shen S,Wang H,Hu Z,Becnel J,Vlak JM. Deltabaculoviruses encode a functional type I budded virus envelope fusion protein. J Gen Virol. 2017 Apr;98(4):847-852. doi: 10.1099/jgv.0.000745. Epub 2017 Apr 28. PMID: 28452294.

43.Shang Y,Wang M,Xiao G,Wang X,Hou D,Pan K,Liu S,Li J,Wang J,Arif BM,Vlak JM,Chen X,Wang H,Deng F,Hu Z. Construction and Rescue of a Functional Synthetic Baculovirus. ACS Synth Biol. 2017 Jul 21;6(7):1393-1402. doi: 10.1021/acssynbio.7b00028. Epub 2017 Apr 6. PMID: 28383905.

44.Zou Z,Liu J,Wang Z,Deng F,Wang H,Hu Z,Wang M,Zhang T. Characterization of two monoclonal antibodies,38F10 and 44D11,against the major envelope fusion protein of Helicoverpa armigera nucleopolyhedrovirus. Virol Sin. 2016 Dec;31(6):490-499. doi: 10.1007/s12250-016-3831-4. Epub 2016 Dec 16. PMID: 27995421.

45.Shi J,Hu S,Liu X,Yang J,Liu D,Wu L,Wang H,Hu Z,Deng F,Shen S. Migration,recombination,and reassortment are involved in the evolution of severe fever with thrombocytopenia syndrome bunyavirus. Infect Genet Evol. 2017 Jan;47:109-117. doi: 10.1016/j.meegid.2016.11.015. Epub 2016 Nov 21. PMID: 27884653.

46.Ning YJ,Deng F,Hu Z,Wang H. The roles of ebolavirus glycoproteins in viral pathogenesis. Virol Sin. 2017 Feb;32(1):3-15. doi: 10.1007/s12250-016-3850-1. Epub 2016 Nov 14. PMID: 27853993;PMCID:PMC6791933.

47.Song J,Wang X,Hou D,Huang H,Liu X,Deng F,Wang H,Arif BM,Hu Z,Wang M. The Host Specificities of Baculovirus per os Infectivity Factors. PLoS One. 2016 Jul 25;11(7):e0159862. doi: 10.1371/journal.pone.0159862. PMID: 27454435;PMCID:PMC4959699.

48.Liu J,Dai S,Wang M,Hu Z,Wang H,Deng F. Virus like particle-based vaccines against emerging infectious disease viruses. Virol Sin. 2016 Aug;31(4):279-87. doi: 10.1007/s12250-016-3756-y. Epub 2016 Jul 11. PMID: 27405928;PMCID:PMC7090901.

49.Zhang Y,Du R,Huang S,Zhang T,Liu J,Zhu B,Wang H,Deng F,Cao S. [Generation of Japanese Encephalitis Virus-like Particle Vaccine and Preliminary Evaluation of Its Protective Efficiency]. Bing Du Xue Bao. 2016 Mar;32(2):150-5. Chinese. PMID: 27396157.

50.Xing J,Liu D,Shen S,Su Z,Zhang L,Duan Y,Tong F,Liang Y,Wang H,Deng F,Hu Z,Zhou Y. Pathologic Studies of Fatal Encephalomyelitis in Children Caused by Enterovirus 71. Am J Clin Pathol. 2016 Jul;146(1):95-106. doi: 10.1093/ajcp/aqw089. Epub 2016 Jun 29. PMID: 27357294.

51.Kuang W,Zhang H,Hou D,Wang M,Deng F,Wang H,Hu Z. P33 of Helicoverpa armigera single nucleocapsid nucleopolyhedrovirus is a functional homolog of AcP33. Virol Sin. 2016 Aug;31(4):346-9. doi: 10.1007/s12250-016-3771-z. PMID: 27167377.

52.Wang J,Zhu Z,Zhang L,Hou D,Wang M,Arif B,Kou Z,Wang H,Deng F,Hu Z. Genome Sequencing and Analysis of Catopsilia pomona nucleopolyhedrovirus: A Distinct Species in Group I Alphabaculovirus. PLoS One. 2016 May 11;11(5):e0155134. doi: 10.1371/journal.pone.0155134. PMID: 27166956;PMCID:PMC4864199.

53.Yin F,Du R,Kuang W,Yang G,Wang H,Deng F,Hu Z,Wang M. Characterization of the viral fibroblast growth factor homolog of Helicoverpa armigera single nucleopolyhedrovirus. Virol Sin. 2016 Jun;31(3):240-8. doi: 10.1007/s12250-016-3710-z. Epub 2016 Apr 28. PMID: 27142667.

54.Shen S,Shi J,Wang J,Tang S,Wang H,Hu Z,Deng F. Phylogenetic analysis revealed the central roles of two African countries in the evolution and worldwide spread of Zika virus. Virol Sin. 2016 Apr;31(2):118-30. doi: 10.1007/s12250-016-3774-9. Epub 2016 Apr 26. PMID: 27129451.

55.Shen S,Wang M,Li X,Li S,van Oers MM,Vlak JM,Braakman I,Hu Z,Deng F,Wang H. Mutational and functional analysis of N-linked glycosylation of envelope fusion protein F of Helicoverpa armigera nucleopolyhedrovirus. J Gen Virol. 2016 Apr;97(4):988-999. doi: 10.1099/jgv.0.000404. Epub 2016 Jan 14. PMID: 26769631.

56.Guo Y,Wang W,Sun Y,Ma C,Wang X,Wang X,Liu P,Shen S,Li B,Lin J,Deng F,Wang H,Lou Z. Crystal Structure of the Core Region of Hantavirus Nucleocapsid Protein Reveals the Mechanism for Ribonucleoprotein Complex Formation. J Virol. 2015 Nov 11;90(2):1048-61. doi: 10.1128/JVI.02523-15. PMID: 26559827;PMCID:PMC4702685.

已授权的专利8项：

1、中国棉铃虫重组基因工程病毒，申请人：王华林、陈新文、孙修炼、胡志红，专利号：ZL00131154.9

2、 一种用于检测乙型肝炎病毒的生物用品，发明人：王华林、周颖、 邓菲、袁丽、胡志红，专利号：ZL200610018346.X

3、 一种用于检测禽流感病毒H5N1亚型的液相芯片，发明人：王华林、夏骏、袁丽、邓菲、胡志红，专利号：ZL 2006 1 0018603.X

4、 高效表达SARS冠状病毒S蛋白的重组杆状病毒及构建，发明人：李娟、王华林、邓菲、胡志红，专 利 号：ZL 2007 1 0052485.9

5、 重组杆状病毒AcBac△cc-GP41及其构建方法，发明人：苏正元、李娟、王华林、邓菲、胡志红、袁丽，专利号：ZL2007 1 0052629.0

6、 用于乙型肝炎病毒共价闭合DNA的检测用品及其应用，发明人：许君、尹飞飞、王华林、邓菲、胡志红，专利号：ZL200810197526.8

7、 用液相芯片检测虫媒或接触传播病原的引物和探针及方法。发明人：王华林、尹飞飞、邓菲、胡志红、袁勤芬。专利号：ZL201110067025.x

8、 用液相芯片检测呼吸道传染病病原的引物和探针及方法。发 明 人：王华林、尹飞飞、邓菲、胡志红，专 利 号：ZL201110067021.1