曹晟

研究方向

（1）研究病毒膜蛋白在病毒入侵宿主细胞过程中发挥的结构与功能作用，为设计新的抗病毒药物提供靶点结构信息。

（2）依托武汉病毒所冷冻电镜研究平台，研究各种病毒的高分辨率结构。

（3）研究病毒蛋白的体外组装模型，开发具有应用前景的新型生物纳米材料。

教育及工作经历

2014-至今，中国科学院武汉病毒研究所，研究员 

2009-2012，明尼苏达大学，博士后

2008-2009，美国康奈尔大学威尔医学院，博士后

2004-2007，中国科学院生物物理研究所，博士

2001-2004，武汉大学，硕士

1997-2001，武汉大学，学士

近五年承担项目

国家重点研发计划（2022YFC2303300），中国科学院基础与交叉前沿科研先导专项（B类，XDB0490401）等。

近五年代表性论文

1．Jia H, Liu S, Rao G, Liu Q, Wu J, Cao S, Gong P. 2025. An evolutionarily unique viral RdRP suggests a common dual-function feature of the priming element. Sci Adv 11:eadv9640.

2．Hu H, Leng C, Shu Y, Peng L, Wu F, Liu J, Zhang X, Zhou W, Xiao Q, Li Y, Wu B, Shen J, Li J, Gong R, Yan B, Deng F, Hu Z, Cao S, Wang M. 2025. Structural insights into hybridoma-derived neutralizing monoclonal antibodies against Omicron BA.5 and XBB.1.16 variants of SARS-CoV-2. J Virol:e0130724.

3．Li Z, Xia H, Rao G, Fu Y, Chong T, Tian K, Yuan Z, Cao S. 2024. Cryo-EM structures of Banna virus in multiple states reveal stepwise detachment of viral spikes. Nat Commun 15:2284.

4．Li H, Zhang Y, Rao G, Zhang C, Guan Z, Huang Z, Li S, Lozach PY, Cao S, Peng K. 2024. Rift Valley fever virus coordinates the assembly of a programmable E3 ligase to promote viral replication. Cell 187:6896-6913 e15.

5．Yang M, Rao G, Li L, Qi L, Ma C, Zhang H, Gong J, Wei B, Zhang XE, Chen G, Cao S, Li F. 2024. Transformation of a Viral Capsid from Nanocages to Nanotubes and Then to Hydrogels: Redirected Self-Assembly and Effects on Immunogenicity. ACS Nano 18:13755-13767.

6．Li L, Chong T, Peng L, Liu Y, Rao G, Fu Y, Shu Y, Shen J, Xiao Q, Liu J, Li J, Deng F, Yan B, Hu Z, Cao S, Wang M. 2024. Neutralizing monoclonal antibodies against the Gc fusion loop region of Crimean-Congo hemorrhagic fever virus. PLoS Pathog 20:e1011948.

7．Liu Q, Zhao H, Li Z, Zhang Z, Huang R, Gu M, Zhuang K, Xiong Q, Chen X, Yu W, Qian S, Zhang Y, Tan X, Zhang M, Yu F, Guo M, Huang Z, Wang X, Xiang W, Wu B, Mei F, Cai K, Zhou L, Zhou L, Wu Y, Yan H, Cao S, Lan K, Chen Y. 2023. Broadly neutralizing antibodies derived from the earliest COVID-19 convalescents protect mice from SARS-CoV-2 variants challenge. Signal Transduct Target Ther 8:347.

8．Yin J, Fu Y, Rao G, Li Z, Tian K, Chong T, Kuang K, Wang M, Hu Z, Cao S. 2022. Structural transitions during the cooperative assembly of baculovirus single-stranded DNA-binding protein on ssDNA. Nucleic Acids Res 50:13100-13113.

9．Li Z, Zhang H, Li Z, Fu Y, Wang X, Li J, Wang K, Wang Z, Zhang T, Wang M, Hu Z, Cao S. 2022. Structural Characterization of Per Os Infectivity Factor 5 (PIF5) Reveals the Essential Role of Intramolecular Interactions in Baculoviral Oral Infectivity. J Virol 96:e0080622.

10．Li N, Rao G, Li Z, Yin J, Chong T, Tian K, Fu Y, Cao S. 2022. Cryo-EM structure of glycoprotein C from Crimean-Congo hemorrhagic fever virus. Virol Sin 37:127-137.

11．Zhang W, Jia Q, Teng Y, Yang M, Zhang H, Zhang XE, Wang P, Ge J, Cao S, Li F. 2021. An Ultrastable Virus-Like Particle with a Carbon Dot Core and Expanded Sequence Plasticity. Small 17:e2101717.