王云

研究方向

高致病性大DNA病毒的防治与新型病毒载体的构建

教育及工作经历

1994-1999 湖北医科大学，临床医学学士

1999-2002 武汉大学第一临床学院，临床医学硕士

2002-2004 武汉科技大学，教师

2004-2008 中国科学院武汉病毒研究所，理学博士

2008-2009 Loyola   University Medical Center,Research Associate

2009-2011中国科学院武汉病毒研究所，助理研究员

2011-2021 中国科学院武汉病毒研究所，副研究员

2021-至今  中国科学院武汉病毒研究所，研究员

近五年承担项目

(1) 科学技术部,国家重大科技专项,2018ZX10711001-006,生物危害4级病原体检测技术及应用评价研究

(2) 中国科学院,院重点部署项目,KJZD-SW-L06-02,非洲猪瘟应急项目

(3) 科学技术部,国家重点研发计划,2020YFC0845900,新冠病毒分子溯源研究

(4) 企业委托，非洲猪瘟双基因缺失疫苗反向遗传系统

(5) 企业委托，猴痘病毒mRNA疫苗免疫原性研究

近五年代表性论文

1. Vaccinia virus tiantan strain is inefficient in eliciting cross-reactive immunity against the emerging monkeypox virus strain. Tian L,Zhang Y,Liu Q,Ruan L,Ren F,Han Y,Zhang Y,Yang L,Li S,Sun H,Zhang Y,Zhou Y,Pei R,Deng F,Huang C,Chen X,Wang Y. Emerg Microbes Infect. 2024 Dec;13(1):2306967.

2. Potential threat of human pathogenic orthopoxviruses to public health and control strategies. Zhang Y,Zhou Y,Pei R,Chen X,Wang Y. J Biosaf Biosecur. 2023 Mar;5(1):1-7

3. Immunization of mice with vaccinia virus Tiantan strain yields antibodies cross-reactive with protective antigens of monkeypox virus. Yang L,Chen Y,Li S,Zhou Y,Zhang Y,Pei R,Chen X,Wang Y. Virol Sin. 2023 Feb;38(1):162-164.

4. Comparison of viral propagation and drug response among SARS-CoV-2 VOCs using replicons capable of recapitulating virion assembly and release. Tian L,Liu Q,Pei R,Chen Y,Xu C,Tang J,Sun H,Liu K,Yang Q,Yang L,Li L,Zhang Y,Zhou Y,Shan C,Hu X,Chen X,Wang Y. Virol Sin. 2022 Oct;37(5):695-703.

5. Efficient assembly of a large fragment of monkeypox virus genome as a qPCR template using dual-selection based transformation-associated recombination. Yang L,Tian L,Li L,Liu Q,Guo X,Zhou Y,Pei R,Chen X,Wang Y. Virol Sin. 2022 Jun;37(3):341-347.

6. Effects of CRM1-dependent nuclear export inhibition on viral structural protein nuclear accumulation during Autographa californica multiple nucleopolyhedrovirus infection. Hu X,Tian L,Li J,Zhou Y,Chen X,Mu J,Bai H,Zhang Y,Wang Y. Virus Res. 2021 Oct 2;303:198504.

7. Major capsid protein of Autographa californica multiple nucleopolyhedrovirus contributes to the promoter activity of the very late viral genes. Bai H,Hu Y,Hu X,Li J,Mu J,Zhou Y,Chen X,Wang Y. Virus Res. 2019 Nov;273:197758.

8. Ac102 Participates in Nuclear Actin Polymerization by Modulating BV/ODV-C42 Ubiquitination during Autographa californica Multiple Nucleopolyhedrovirus Infection. Zhang Y,Hu X,Mu J,Hu Y,Zhou Y,Zhao H,Wu C,Pei R,Chen J,Chen X,Wang Y. J Virol. 2018 May 29;92(12):e00005-18.