李淑芬

研究方向

高致病性病毒感染诱发重度炎症机制及干预策略研究教育及工作经历

教育及工作经历

2023.10-至今，中国科学院武汉病毒研究所，青年研究员近五

2021.10-2023.10，中国科学院武汉病毒研究所，副研究员

2017.07-2021.10，中国科学院武汉病毒研究所，助理研究员

2015.07-2017.06，广东出入境检验检疫局/广州医科大学，博士后

2009.09-2015.06，中国科学院武汉病毒研究所，博士

2005.09-2009.06，南昌大学，学士

近五年承担项目

1. 国家自然科学基金面上项目  2024.01-2027.12  在研  项目负责人

2.国家自然科学基金青年项目  2020.01-2022.12  结题  项目负责人

3.中国科学院重点部署项目  2022.01-2023.12  结题  项目负责人

4.中国科学院先导专项  2023.09-2028.08  在研  项目骨干

5. 国家重点研发计划  2023.12-2026.11  在研  课题骨干

6.国家重点研发计划  2018.05-2023.04  结题  课题骨干

近五年代表性论文

1. Shufen Li#, Hao Li#, Zhenxing Zhou#, Meidi Ye, Yifei Wang, Wenqin Li, Zhenqiong Guan, Zihan Guan, Chongtao Zhang, Yulan Zhang, Wei Liu, Ke Peng*. A viral necrosome mediates direct RIPK3 activation to promote inflammatory necroptosis. PNAS. 2025, 122(22): e2420245122.

2. Shufen Li#, Yulan Zhang#, Zhenqiong Guan#, Meidi Ye, Huiling Li, Miaomiao You, Zhenxing Zhou, Chongtao Zhang, Fan Zhang, Ben Lu*, Peng Zhou*, Ke Peng*. SARS-CoV-2 Z-RNA activates the ZBP1-RIPK3 pathway to promote virus-induced inflammatory responses. Cell Research. 2023, 33(3):201-214.

3. Shufen Li#, Hao Li#, YuLan Zhang, Qi-Lin Xin, Zhen-Qiong Guan, Xi Chen Xiao-Ai Zhang, Xiao-Kun Li, Geng-Fu Xiao, Pierre-Yves Lozach, Jun Cui, Wei Liu * Lei-Ke Zhang* and Ke Peng*. SFTSV Infection Induces BAK/BAX-Dependent Mitochondrial DNA Release to Trigger NLRP3 Inflammasome Activation. Cell Reports. 2020, 30(13):4370-4385.

4. Shufen Li#, Yulan Zhang#, Zhenqiong Guan#, Huiling Li, Meidi Ye, Xi Chen, Jun Shen, Yiwu Zhou, Zhengli Shi, Peng Zhou* and Ke Peng*. SARS-CoV-2 triggers inflammatory responses and cell death through caspase-8 activation. Signal Transduction and Targeted Therapy. 2020, 5(1):235.

5. Shufen Li*#, Meidi Ye#, Yuanqiao Chen, Yulan Zhang, Jiachen Li, Wei Liu, Hao Li* and Ke Peng*. Screening of a Small Molecule Compound Library Identifies Toosendanin as an Inhibitor Against Bunyavirus and SARS-CoV-2. Frontiers in Pharmacology. 2021, 11:735223.

6. Shufen Li, Xiangtao Zhu, Zhenqiong Guan, Wenfeng Huang, Yulan Zhang, Jeroen Kortekaas, Pierre-Yves Lozach and Ke Peng*. NSs Filament Formation Is Important but Not Sufficient for RVFV Virulence In Vivo. Viruses. 2019, 11(9):834.

7. Shufen Li, Yun Wang, Dianhai Hou, Zhenqiong Guan, Shu Shen, Ke Peng, Fei Deng, Xinwen Chen, Zhihong Hu, Hualin Wang and Manli Wang*. Host factor heat-shock protein 90 contributes to baculovirus budded virus morphogenesis via facilitating nuclear actin polymerization. Virology. 2019, 535: 200-209.

8. Haiyu Xu#, Shufen Li#, Jiayuan Liu#, Jinlong Cheng, Liping Kang, Weijie Li, Yute Zhong, Chaofa Wei, Lifeng Fu, Jianxun Qi, Yulan Zhang, Miaomiao You, Zhenxing Zhou, Chongtao Zhang, Haixia Su, Sheng Yao, Zhaoyin Zhou, Yulong Shi, Ran Deng, Qi Lv, Fengdi Li, Feifei Qi, Jie Chen, Siqin Zhang, Xiaojing Ma, Zhijian Xu, Shao Li, Yechun Xu, Ke Peng, Yi Shi, Hualiang Jiang, George F Gao*, Luqi Huang*. Bioactive compounds from Huashi Baidu decoction possess both antiviral and anti-inflammatory effects against COVID-19. PNAS. 2023, 120(18): e2301775120.

9. Yuanling Yu#, Meiyu Wang#, Xiaoai Zhang#, Shufen Li#, Qingbin Lu, Haolong Zeng, Hongyan Hou, Hao Li, Mengyi Zhang, Fei Jiang, Jiajing Wu, Ruxia Ding, Zehua Zhou, Min Liu, Weixue Si, Tao Zhu, Hangwen Li, Jie Ma, Yuanyuan Gu, Guangbiao She, Xiaokun Li, Yulan Zhang, Ke Peng, Weijin Huang*, Wei Liu* and Youchun Wang*. Antibody-dependent cellular cytotoxicity response to SARS-CoV-2 in COVID-19 patients. Signal Transduction and Targeted Therapy. 2021, 6(1):346.

10. Xu-Rui Shen#, Rong Geng#, Qian Li#, Ying Chen#, Shu-Fen Li#, Qi Wang, Juan Min, Yong Yang, Bei Li, Ren-Di Jiang, Xi Wang, Xiao-Shuang Zheng, Yan Zhu, Jing-Kun Jia, Xing-Lou Yang, Mei-Qin Liu, Qian-Chun Gong, Yu-Lan Zhang, Zhen-Qiong Guan, Hui-Ling Li, Zhen-Hua Zheng, Zheng-Li Shi, Hui-Lan Zhang*, Ke Peng, Peng Zhou*. ACE2-independent infection of T lymphocytes by SARS-CoV-2. Signal Transduction and Targeted Therapy. 2022, 7(1):83.