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博士生导师

袁志明

来源: 时间:2021-11-18


名:袁志明

职称职务:研究员

电子邮箱:yzm@wh.iov.cn

研究方向



1.蚊传病毒特性和传播风险

2.蚊传病毒与媒介相互作用

3.新发病毒的防控技术研究

教育及工作经历

1980年9月-1984年6月 湖北大学 生物系 获得学士学位

1984年9月-1987年6月 云南大学 生物系 获得硕士学位

1989年9月-2000年6月 中山大学 微生物学 博士学位

1987年10月-1989年11月,在云南大学生科院任助教;

1989年11月-1996年03月,在中科院武汉病毒所任助理研究员 ;

1996年03月-1999年05月,在中科院武汉病毒所任副研究员;

1999年05月-现在,在中科院武汉病毒所任研究员,虫媒病毒媒介控制学科组组长;

1995年-2003年期间,分别在法国CIRAD、巴斯德研究所、丹麦皇家农业和畜牧大学、丹麦国立环境研究所和美国ILLINOIS大学从事合作研究;

2004年-2013年,任中科院武汉病毒所党委书记,副所长;

2012年至今,任中国科学院武汉分院院长、武汉国家生物安全实验室主任。

近五年承担项目

1、科技部国家重点研发计划项目项目名称:新型冠状病毒(2019-nCov)动物模型研究;

2、国家重点研发项目, 项目名称:新型冠状病毒基因组变异的生物学功能的动物模型评估技术体系与临床验证;

3、科技部科技部基础性工作专项项目名称:我国重要自然宿主及媒介昆虫的病毒病原调查;

4、新药创制重大专项课题项目名称:埃博拉病毒病马和猴抗血清的应急制备;

5、传染病重大专项课题课题名称:四级危害病原检测技术及实验室安全评价指标

6、国家自然科学基金-联合基金项目,项目名称:埃博拉病毒、尼帕病毒、拉沙病毒的新型载体疫苗研究

7、中科院国际伙伴计划, 项目名称马尔堡和克里米亚-刚果出血热病毒检测方法的标准化研究;

8、中科院科技促进发展项目:生物安全关键防护技术与产品研发;

近五年代表性论文

发表论文:

发表论文:

1.Fei Wang,Cihan Yang,Shunlong Wang,Qun Wu,Christabel   Ochieng,Zhiming Yuan,Han Xia*Experimental Viral Infection in Adult Mosquitoes by Oral Feeding   and Microinjection, J Vis Exp, 2022, 28: (185).

2.Gao G, Hu X, Zhou Y, Rao J, Zhang X, Peng   Y, Zhao J, Yao Y, Liu K, Liang M, Liu H, Deng F, Xia H*, Shan C*, Yuan Z*,Infection and   pathogenesis of the Delta variant of SARS-CoV-2 in Rhesus macaque.Virol Sin. 2022, 37(2):299-302.

3.Huang Y, Xiao   S, Song D, Yuan Z*, Evaluating the virucidal activity of four disinfectants   against SARS-CoV-2.Am J Infect Control. 2022; 50(3):319-324.

4.Huang Y, Xiao S, Song D, Yuan Z*, Evaluation   and comparison of three virucidal agents on inactivation of Nipah virus. Sci   Rep. 2022, 12(1):11365.

5.Huang Y, Zhang H, Li X, Zhao L, Cai D,   Wang S, Ren N, Ma H, Huang D, Wang F, Yuan Z, Zhang B*, Xia H*,In Vitro and   In Vivo Characterization of a New Strain of Mosquito Flavivirus Derived from Culicoides.Viruses. 2022, 14(6):1298.

6.Liang M, Tai W, Wang Y, Dai Y, Yao Y, Min   J, Zhou Y, Liu L, Shan C, Xia H, Yuan Z*.SARS-CoV-2 infection induces   testicular injury in Rhesus macaque.Virol Sin. 2022 Oct 28:S1995-820X(22)00183-3. doi:   10.1016/j.virs.2022.10.008. Online ahead of print.

7.Lu M, Liu K, Peng Y, Ding Z, Li Y, Tendu   A, Hu X, Gao G, Guo W, Liu H, Rao J, Zhao J, Chen M, Yuan Z, Wong G*, Shan C*,   Yao Y*, Lan J*, Recombinant chimpanzee adenovirus vector vaccine expressing   the spike protein provides effective and lasting protection against   SARS-CoV-2 infection in mice, Virol Sin. 2022, 37(4):581-590.

8.Ren N, Wang F, Zhao L, Wang S, Zhang G,   Li J, Zhang B, Wang J, Bergeron E, Yuan Z*, Xia H*Efficient rescue of a newly   classified Ebinur lake orthobunyavirus with GFP reporter and its application   in rapid antiviral screening, Antiviral Res. 2022 Sep 20:105421. doi:   10.1016/j.antiviral.2022.105421

9.Wang Haomeng, Zhao   Chen, Zhenghua Wang, Jin Li, Zhihong Yan, Jinbo Yuan, Airu Zhu, Lan Chen, Ye Liu,   Chenlong Hu, Ali Zhu, Guowei Li, Yuehu Li, Jie Deng, Liqiao Ma, Xiuwen Sui, Wei   Miao, Junqiang Li, Xiuyu Zheng, Jinhua Piao, Yanfeng Yao, Juhong Rao, Chao Shan,   Zhiming Yuan, Jincun Zhao*,and Tao Zhu*, mRNA based vaccines provide broad   protection against different SARS-CoV-2 variants of concernEmerging Microbes   & Infections, 2022, 11:1550-1553

10.Wang Z, An J, Liu K, Yu P, Fang X, Li J,   Zhu H, Zhu Q, Huang C, Zhang C, Zhao B, Bao L, Song Y, Cao X, Hu D, Jiang Y,   Shi L, Zhou L, Fan J, Guan W, Zhou C, Hu Z, Yuan Z*, Liu J*, Shan C,* Liu G*,   A potent, broadly protective vaccine against SARS-CoV-2 variants of concern, NPJ   Vaccines. 2022 Nov 12;7(1):144. doi: 10.1038/s41541-022-00571-0.

11.Xia Han, Yuan   Zhiming*, High-containment facilities and the role they play in global health   security, JOBB, 2022, 4(1): 1-4

12.Yang C, Wang F, Huang D, Ma H, Zhao L,   Zhang G, Li H, Han Q, Bente D, Salazar FV, Yuan Z*, Xia H*Vector   competence and immune response of Aedes aegypti for Ebinur Lake virus, a   newly classified mosquito-borne orthobunyavirus.PLoS Negl Trop Dis. 2022 Jul   18;16(7):e0010642. doi: 10.1371/journal.pntd.0010642

13.Gu C, Cao X, Wang   Z, Hu X, Yao Y, Zhou Y, Liu P, Liu X, Gao G, Hu X, Zhang Y, Chen Z, Gao L,   Peng Y, Jia F, Shan C, Yu L, Liu K, Li N, Guo W, Jiang G, Min J, Zhang J,   Yang L, Shi M, Hou T, Li Y, Liang W, Lu G, Yang C, Wang Y, Xia K, Xiao Z, Xue   J, Huang X, Chen X, Ma H, Song D, Pan Z, Wang X, Guo H, Liang H, Yuan Z*,   Guan W*, Deng SJ*.,A human   antibody of potent efficacy against SARS-CoV-2 in rhesus macaques showed   strong blocking activity to B.1.351.MAbs. 2021 Jan-Dec; 13(1):1930636.   doi: 10.1080/19420862.2021.1930636.

14.Guo Y, Huang L,   Zhang G, Yao Y, Zhou H, Shen S, Shen B, Li B, Li X, Zhang Q, Chen M, Chen D,   Wu J, Fu D, Zeng X, Feng M, Pi C, Wang Y, Zhou X, Lu M, Li Y, Fang Y, Lu YY,   Hu X, Wang S, Zhang W, Gao G, Adrian F, Wang Q, Yu F, Peng Y, Gabibov AG, Min   J, Wang Y, Huang H, Stepanov A, Zhang W, Cai Y, Liu J, Yuan Z, Zhang C, Lou   Z, Deng F, Zhang H, Shan C, Schweizer L, Sun K, Rao ZA SARS-CoV-2   neutralizing antibody with extensive Spike binding coverage and modified for   optimal therapeutic outcomes, Nat Commun. 2021 May 11;12(1):2623. doi:   10.1038/s41467-021-22926-2

15.Lu Zhao, Huanle Luo, Doudou Huang,Ping Yu, Qiannan Dong,Caroline Mwaliko,Evans Atoni, Raphael   Nyaruaba, Jiangling Yuan, Guilin Zhang,Dennis Bente, Zhiming Yuan*, and,Han Xia*, Pathogenesis   and Immune Response of Ebinur Lake Virus: A Newly Identified Orthobunyavirus That   Exhibited Strong Virulence in Mice, Front. Microbiol., 01 February 2021https://doi.org/10.3389/fmicb.2020.625661

16.Mwaliko C,   Nyaruaba R, Zhao L, Atoni E, Karungu S, Mwau M, Lavillette D, Xia H*, Yuan   Z*,Zika virus   pathogenesis and current therapeutic advances.Pathog Glob   Health. 2021, 115(1):21-39.

17.Pan X, Shi J, Hu   X, Wu Y, Zeng L, Yao Y, Shang W, Liu K, Gao G, Guo W, Peng Y, Chen S, Gao X,   Peng C, Rao J, Zhao J, Gong C, Zhou H, Lu Y, Wang Z, Hu X, Cong W, Fang L,   Yan Y, Zhang J, Xiong H, Yi J, Yuan Z*, Zhou P*, Shan C*, Xiao G*.,RBD-homodimer, a COVID-19 subunit vaccine candidate, elicits   immunogenicity and protection in rodents and nonhuman primates.Cell Discov.   2021,7(1): 82. .

18.Peiling Geng,Jiao Cheng,Zhiming Yuan,Hairong Xiong,Haiying Wang,Xiaomin Hu*, Horizontal transfer of large plasmid with type IV   secretion system and mosquitocidal genomic island with excision and   integration capabilities in Lysinibacillus sphaericus, Environ Microbiol, 2021,   23(9):5131-5146.

19.Ren N, Wang X,   Liang M, Tian S, Ochieng C, Zhao L, Huang D, Xia Q, Yuan Z*, Xia H*.Characterization of a novel reassortment Tibet orbivirus isolated from   Culicoides spp. in Yunnan, PR China.J Gen Virol. 2021 Sep;102(9). doi:   10.1099/jgv.0.001645.

20.Wan X, Geng P,   Sun J, Yuan Z*, Hu X*,Characterization   of two newly isolated bacteriophages PW2 and PW4 and derived endolysins with   lysis activity against Bacillus cereus group strains.Virus Res. 2021   Jun 16:198489. doi: 10.1016/j.virusres.2021.198489. Online ahead of   print.PMID: 34146612

21.Yao YF, Wang ZJ,   Jiang RD, Hu X, Zhang HJ, Zhou YW, Gao G, Chen Y, Peng Y, Liu MQ, Zhang YN,   Min J, Lu J, Gao XX, Guo J, Peng C, Shen XR, Li Q, Zhao K, Yang L, Wan X,   Zhang B, Wang WH, Wu J, Zhou P, Yang XL, Shen S*, Shan C*, Yuan ZM*, Shi ZL*,  Protective Efficacy of Inactivated Vaccine against SARS-CoV-2 Infection   in Mice and Non-Human Primates.Virol Sin. 2021, 36(5):879-889.

22.Zhang YN, Liu SQ,   Deng CL, Yuan ZM, Zhang B, Li XD, Ye HQ*, Development and Characterization of   SYBR Green I Based RT-PCR Assay for Detection of Omsk Hemorrhagic Fever   Virus., Virol Sin. 2021, 36(6):1644-1647.

23.Zhang YN, Zhang   ZR, Zhang HQ, Li XD, Li JQ, Zhang QY, Liu J, Li Q, Deng CL, Shi ZL, Yuan ZM,   Ye HQ, Zhang B, Increased morbidity of obese mice infected with mouse-adapted   SARS-CoV-2, Cell Discov. 2021, 7(1):74.

24.Atoni EvansLu Zhao, Cheng Hu,   Ren Najie, Xiaoyu Wang, Mengying Liang,Caroline Mwaliko, Zhiming Yuan*, Han Xia*, A dataset of distribution   and diversity of mosquito-associated viruses and their mosquito vectors in   ChinaScientific Data, 2020, 7(1): 342.

25.FengLiqiang,Qian Wang,Chao Shan,Chenchen Yang,Ying Feng,Jia Wu,Xiaolin Liu,Yiwu Zhou,Rendi Jiang,Peiyu Hu,Xinglong Liu,Fan Zhang,Pingchao Li,Xuefeng Niu,Yichu Liu,Xuehua Zheng,Jia Luo,Jing Sun,Yingying Gu,Bo Liu,Yongcun Xu,Chufang Li,Weiqi Pan,Jincun Zhao,Changwen Ke,Xinwen Chen,Tao Xu,Nanshan Zhong,Suhua Guan,Zhiming Yuan*,Ling Chen*, An adenovirus-vectored COVID-19 vaccine confers   protection from SARS-COV-2 challenge in rhesus macaques, Nature   Communications, 2020, 11(1):4207.

26.Hu X, Huang D,   Ogalo J, Geng P, Yuan Z, Xiong H, Wan X, Sun J, Application of Bacillus   thuringiensis strains with conjugal and mobilizing capability drives gene   transmissibility within Bacillus cereus group populations in confined   habitats, BMC Microbiol. 2020 Nov 26;20(1):363. doi:   10.1186/s12866-020-02047-4.

27.Li N, Zhang ZR,   Zhang YN, Liu J, Deng CL, Shi PY, Yuan ZM, Ye HQ, Zhang B,A replication-defective Japanese encephalitis virus (JEV) vaccine   candidate with NS1 deletion confers dual protection against JEV and West Nile   virus in mice.NPJ Vaccines. 2020, 5:73.

28.Shan C, Yao YF,   Yang XL, Zhou YW, Gao G, Peng Y, Yang L, Hu X, Xiong J, Jiang RD, Zhang HJ,   Gao XX, Peng C, Min J, Chen Y, Si HR, Wu J, Zhou P, Wang YY, Wei HP, Pang W,   Hu ZF, Lv LB, Zheng YT, Shi ZL,Yuan ZM*Infection with   Novel Coronavirus (SARS-CoV-2) Causes Pneumonia in the Rhesus Macaques,   Cell Res. 2020, 30(8):670-677

29.Shi C, Zhao L, Atoni E, Zeng W, Hu X, Matthijnssens J, Yuan Z*, Xia H*,   Stability of the Virome in Lab- and Field-Collected Aedes albopictus   Mosquitoes across Different Developmental Stages and Possible Core Viruses in   the Publicly Available Virome Data of Aedes Mosquitoes.mSystems. 2020   Sep 29;5 (5):e00640-20. doi: 10.1128/mSystems.00640-20.

30.Shi R, Shan C,   Duan X, Chen Z, Liu P, Song J, Song T, Bi X, Han C, Wu L, Gao G, Hu X, Zhang   Y, Tong Z, Huang W, Liu WJ, Wu G, Zhang B, Wang L, Qi J, Feng H, Wang FS, Wang   Q, Gao GF, Yuan Z*, Yan J*. A human neutralizing antibody targets the   receptor binding site of SARS-CoV-2. Nature. 2020, 584(7819):120-124.

31.Shuang Wang,Yun Peng,Rongjuan Wang,Shasha Jiao,Min Wang,Weijin Huang,Chao Shan,Wen Jiang,Zepeng Li,Chunying Gu,Ben Chen,Xue Hu,Yanfeng Yao,Juan Min,Huajun Zhang,Ying Chen,Ge Gao,Peipei Tang,Gang Li,An Wang,Lan Wang,Jinchao Zhang,Shuo Chen,Xun Gui,Zhiming Yuan*Datao Liu, Characterization of neutralizing   antibody with prophylactic and therapeutic efficacy against SARS-CoV-2 in   rhesus monkeys,Nature   Communications, 2020, 11(1):5752

32.Wang ZJ, Zhang   HJ, Lu J, Xu KW, Peng C, Guo J, Gao XX, Wan X, Wang WH, Shan C, Zhang SC, Wu   J, Yang AN, Zhu Y, Xiao A, Zhang L, Fu L, Si HR, Cai Q, Yang XL, You L, Zhou   YP, Liu J, Pang DQ, Jin WP, Zhang XY, Meng SL, Sun YX, Desselberger U, Wang   JZ, Li XG, Duan K, Li CG, Xu M, Shi ZL, Yuan ZM*, Yang XM*, Shen S*, Low   Toxicity and High Immunogenicity of an Inactivated Vaccine Candidate against   COVID-19 in different animal modelsEmerg Microbes Infect. 2020 Nov   26;1-49. doi: 10.1080/22221751.2020.1852059. Online ahead of print.

33.Xia H, Atoni E,   Zhao L, Ren N, Huang D, Pei R, Chen Z, Xiong J, Nyaruaba R, Xiao S, Zhang B,   Yuan Z*,SARS-CoV-2   Does Not Replicate in Aedes Mosquito Cells nor Present in Field-Caught   Mosquitoes from Wuhan.Virol Sin. 2020, 35(3):355-358.

34.Xia H, Liu R,   Zhao L, Sun X, Zheng Z, Atoni E, Hu X, Zhang B, Zhang G, Yuan Z*, Characterization of Ebinur Lake Virus and Its Human Seroprevalence at   the China-Kazakhstan Border.Front Microbiol. 2020, 10:3111.

XiaShengli,Kai Duan,Yuntao Zhang,Dongyang Zhao,Huajun Zhang,Zhiqiang Xie,Xinguo Li,Cheng Peng,Yanbo Zhang,Wei Zhang,Yunkai Yang,Wei Chen,Xiaoxiao Gao,Wangyang You,Xuewei Wang,Zejun Wang,Zhengli Shi,Yanxia Wang,Xuqin Yang,Lianghao Zhang,Lili Huang,Qian Wang,Jia Lu,Yongli Yang,Jing Guo,Wei Zhou,Xin Wan,Cong Wu,Wenhui Wang,Shihe Huang,Jianhui Du,Ziyan Meng,An Pan,Zhiming Yuan,Shuo Shen,Wanshen Guo,Xiaoming Yang. Effect of an Inactivated Vaccine Against SARS-CoV-2   on Safety and Immunogenicity Outcomes: Interim Analysis of 2 Randomized   Clinical Trials, JAMA, 2020 324(10):1-10.

35.Ye G, Wang Y, Liu   X, Dong Q, Cai Q, Yuan Z*, Xia H*Transmission competence of a new   mesonivirus, Yichang virus, in mosquitoes and its interference with   representative flaviviruses., PLoS Negl Trop Dis. 2020 Nov 30;14(11):e0008920.   doi: 10.1371/journal.pntd.0008920. Online ahead of

36.Zhang QY, Li XF,   Niu X, Li N, Wang HJ, Deng CL, Ye HQ, Huang XY, Chen Q, Xu YP, Dong HL, Li   XD, Zhao H, Shi PY, Yuan ZM, Gong P, Fang X, Qin CF, Zhang B.,Short direct repeats in the 3'-untranslated region are involved in   subgenomic flaviviral RNA production.J Virol. 2020 Jan 2. pii:   JVI.01175-19. doi: 10.1128/JVI.01175-19. [Epub ahead of print]

37.Zhang XY, Guo J,   Wan X, Zhou JG, Jin WP, Lu J, Wang WH, Yang AN, Liu DX, Shi ZL, Yuan ZM, Li   XG, Meng SL, Duan K, Wang ZJ, Yang XM, Shen SBiochemical and antigenic   characterization of the structural proteins and their post-translational   modifications in purified SARS-CoV-2 virions of an inactivated vaccine   candidate, Emerg Microbes Infect. 2020 Nov 26:1-49. doi:   10.1080/22221751.2020.1852059. Online ahead of print.PMID: 33241728.

38.ZhangYa-Nan,Xiao-Dan Li,Zhe-Rui Zhang,Hong-Qing Zhang,Na Li,Jing Liu,Jia-Qi Li,Hua-Jun Zhang,Ze-Jun Wang,Shuo Shen,Zheng-Li Shi,Hong-Ping Wei,Zhi-Ming Yuan,Han-Qing Ye,Bo ZhangA mouse model for SARS-CoV-2 infection by exogenous   delivery of hACE2 using alphavirus replicon particles, Cell Res., 2020, 25:   1-3.

39.Zhang YN, Zhang   QY, Li XD, Xiong J, Xiao SQ, Wang Z, Zhang ZR, Deng CL, Yang XL, Wei HP, Yuan   ZM, Ye HQ, Zhang BGemcitabine,   lycorine and oxysophoridine inhibit novel coronavirus (SARS-CoV-2) in cell   culture, Emerg Microbes Infect. 2020, 9(1): 1170-1173.

40.Zhang Zhe-Rui,   Ya-Nan Zhang, Xiao-Dan Li, Hong-Qing Zhang, Shu-Qi Xiao, Fei Deng, Zhi-Ming   Yuan, Han-Qing Ye & Bo Zhang,A cell-based large-scale screening of natural compounds for inhibitors   of SARS-CoV-2, Signal Transduction and Targeted Therapy, 2020, 5(1):218

41.Evans Atoni,Lu Zhao,Samuel, Karungu, Vincent Obanda, Bernard, Agwanda, Han Xia, Zhiming   Yuan*, The discovery and global distribution of novel to- associated viruses   in the last decade  (2007-2017)Rev Med Virol.2019 29(6):e2079.

42.Hou M., D.L.   Song, Z.L. Shi, Z.M. Yuan*,Quality management in a high-containment laboratory, J. Biosafety   Biosecurity, 2019, 1(34-38).

James W. LeDuc,   Yuan Zhiming, Safety and Security in the Age of Synthetic Biology, J.   Biosafety Biosecurity, 2019, 1(77-79).

43.Li N, Zhang YN,   Deng CL, Shi PY, Yuan ZM, Zhang B*.Replication-Defective   West Nile Virus with NS1 Deletion as a New Vaccine Platform for Flavivirus, J Virol. 2019,   93(17). pii: e00720-19. doi: 10.1128/JVI.00720-19.

44.Li XD, Deng CL,   Yuan ZM, Ye HQ, Zhang B*.Different   Degrees of 5'-3' DAR Interactions Modulate Zika Virus Genome Cyclization and   Host Specific Replication.J Virol. 2019 Dec 11. pii:   JVI.01602-19. doi: 10.1128/JVI.01602-19.

45.Samuel Karungu,Evans Atoni,Joseph Ogalo,Caroline Mwaliko, Bernard Agwanda, Zhiming Yuan*,Xiaomin Hu*Mosquitoes of Etiological Concern in Kenya and Possible Control   Strategies, June 2019, Insects, 10(6), DOI:10.3390/insects10060173

46.Tian S,Xiong H,Geng P,Yuan Z*,Hu X*, HesH Represses Cereulide Synthesis as an   Alpha/Beta Fold Hydrolase in Bacillus cereus, Toxins.2019, 21;11(4).

47.Xia H,Huang Y,Ma H,Liu B,Xie W,Song D,Yuan Z*, Biosafety Level 4 Laboratory User Training Program,   China,Emerg Infect   Dis.2019 May;25(5). doi: 10.3201/eid2505.180220.

48.Xia H,Zhao N,Zhao L,Wang Y,Zhao W,Yuan Z*. Rapid detection of    Banna virus by reverse transcription-loop-mediated isothermal   amplification  (RT-LAMP)Int J Infect   Dis.2019, Jan; 78:93-98. doi: 10.1016/j.ijid.2018.10.025. Epub   2018 Nov. 3.

49.Xu Jianguo,   Zhiming Yuan,Inaugural editorial: Towards evidence-based biosafety and biosecurity, J. Biosafety   Biosecurity, 2019, 1(1-2).

50.Yuan Zhiming,   Current Status and Future Challenges of High-level Biosafety Laboratories in   China, J. Biosafety Biosecurity, 2019, 1(123-127).

51.Zhang HL, Dong   HL, Zhang YN, Xu LL, Deng CL, Li XF, Li XD, Ye HQ, Yuan ZM, Qin CF, Zhang B.Visualization of chikungunya virus infection in vitro and in vivo, Emerg Microbes   Infect. 2019, 8(1):1574-1583. doi: 10.1080/22221751.2019.1682948.

52.Zhang X,Karungu S,Cai Q,Yuan Z*,Hu X*,Effects of Propoxur Exposure on   Insecticidal Susceptibility and Developmental Traits in Culex pipiens quinquefasciatus, Insect, 2019   Sep 7;10(9). pii: E288. doi: 10.3390/insects10090288.

53.Zhao L,Mwaliko C,Atoni E,Wang Y,Zhang Y,Zhan J,Hu X,Xia H*,Yuan Z*. Characterization of a Novel Tanay Virus Isolated   From Anopheles sinensis Mosquitoes in Yunnan, China,Front Microbiol.2019 Aug   22;10:1963. doi: 10.3389/fmicb.2019.01963. eCollection 2019.

54.Atoni E, Waruhiu   C, Nganga S, Xia H, Yuan Z*, Arboviruses of Human Health significance in   Kenya, Afr J Health Sci. 2018; 31(1):121-141

55.Atoni E,Wang Y,Karungu S,Waruhiu C,Zohaib A,Obanda V,Agwanda B,Mutua M,Xia H,Yuan Z*Metagenomic Virome   Analysis of Culex Mosquitoes from Kenya and ChinaViruses.2018, Jan. 12;10(1). pii: E30. doi: 10.3390/v10010030.

56.Fu P,Ge Y,Hu Y,Yuan Z*,Hu X*A toxin-antitoxin system is essential for the stability of   mosquitocidal plasmid pBsph of Lysinibacillus sphaericus.Microbiol Res.2018,   214:114-122.

57.Geng P,Wan X,Cheng J,Yuan Z*, Hu X*, vB_LspM-01: A novel myovirus displaying   pseudolysogeny in Lysinibacillus sphaericus C3-41,Appl Microbiol   Biotechnol.2018, 102(24):10691-1070

58.Hu Y,Cai Q,Tian S,Ge Y,Yuan Z*,Hu X*Regulator DegU is   required for multicellular behavior in Lysinibacillus sphaericus,Res Microbiol.2018,   169(3):177-18.

59.Le Duc JW,Yuan Z, Network for safe and secure labs.,Science, 2018,   362(6412):267.

60.Liu X, Liu Y,   Zhang Q, Zhang B, Xia H,Yuan Z*,Homologous RNA   secondary structure duplications in 3' untranslated region influence subgenomic   RNA production and replication of dengue virus.Virology. 2018,   30;524:114-126.

61.Samuel KarunguDoudou HuangEvans AtoniCecilia RumberiaBernard AgwandaXiaomin HuZhi-ming Yuan*Isolation, identification   and evaluation of mosquito entomopathogenic Bacillus species and related   genera from randomly selected sites in Kenya, Afr. J. Microbiol. Res. March   2018, 12(12), DOI10.5897/AJMR2018.8824

62.Xia H, Wang Y,   Atoni E, Zhang B,Yuan Z*Mosquito-Associated   Viruses in China.Virol Sin. 2018, 33(1):5-20.

63.Xia H, Wang Y,   Shi C, Atoni E, Zhao L,Yuan Z*Comparative   Metagenomic Profiling of Viromes Associated with Four Common Mosquito Species   in China.Virol Sin. 2018, 33(1):59-66.

64.Xia H,Liu H,Zhao L,Atoni E,Wang Y,Yuan Z*First Isolation and characterization of a Group C Banna Virus   (BAV) from Anopheles sinensis Mosquitoes in Hubei, China,Viruses.2018 Oct 11;10(10). pii: E555. doi:   10.3390/v10100555.

65.Yuan Z*Investigation   of Viral Pathogen Profiles in Some Natural Hosts and Vectors in China.Virol Sin. 2018,   33(1):1-4.

出版专著:

1.    法国生物安全法律法规选编,袁志明主编,科学出版社,20156月出版

2.  Collection of Laws, Regulations and   Standards of the Peoples Republic of China on   Biosafety》即:《中国生物安全法律法规标准英文汇编》,袁志明主编,科学出版社201112月出版。

专利申请:

3.  防护实验室围护结构。中华人民共和国国家知识产权局发明专利,授权专利号:ZL   2014 10714141.X

4.  高级别防护实验室围护结构。中华人民共和国国家知识产权局实用新型专利,授权专利号:ZL 2014 20740059.X

5.  一种登革病毒/黄热病毒/西尼罗病毒/基孔肯雅病毒鉴别检测试剂盒。中华人民共和国国家知识产权局发明专利,授权专利号:ZL201210282195.4

6.  一种带有荧光素酶基因的JEV感染性克隆及构建方法和应用 。发明人:张波,李晓丹,秦成峰,李晓峰,袁志明,邓成林,单超,叶寒青   。申请(专利)号:CN201310441707.1

7.  一种拉沙热病毒核蛋白及制备方法和应用。发明人:袁志明、黄弋、杨梦诗。申请号:201610011711.8

8.  一种带有双报告基因的登革病毒2型复制子的细胞系及应用。发明人:张波,商宝娣,张盼涛,邓成林,袁志明,史佩勇。申请(专利)号:201410104868.6

9.  一种表达埃博拉GP蛋白的重组黄热病毒的制备方法及应用.发明人:袁志明;张振清;黄弋;张波;蔡全信。申请(专利)号:CN201410500030.9

10.一种带有绿色荧光蛋白基因的CA16感染性克隆及构建方法和应用。发明人:张波;邓成林;徐琳琳;秦成峰;李晓丹;袁志明;叶寒青。申请(专利)号:CN201410077204.5

检验检疫行业标准制定:

11.马尔堡病毒RT-PCR和实时荧光RT-PCR检测方法。检验检疫行业标准(SN/T 3558-2013)

12.国境口岸拉沙热病毒的荧光PCR快速检测方法。检验检疫行业标准(SN/T 4163-2015)

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