王延轶

研究方向

病毒与宿主相互作用

炎症反应调控机制

教育及工作经历

2000.09-2004.06   北京大学生命科学学院                    学士

2004.08-2006.06   美国科罗拉多大学医学院免疫学系       硕士

2007.09-2010.06   武汉大学生命科学学院                    博士

2006.09-2010.10   武汉大学生命科学学院                    讲师

2010.11-2012.02   武汉大学生命科学学院                    副教授

2012.03--           中国科学院武汉病毒所分子免疫学学科组     研究员/学科组长

2014.12--2015.12  中国科学院武汉病毒所                         所长助理

2015.12--2018.10  中国科学院武汉病毒所                         副所长

2018.10.15--        中国科学院武汉病毒所                        所长

近五年承担项目

国家自然科学基金联合基金项目，U23A20168, 克里米亚-刚果出血热病毒（CCHFV）感染复制与宿主天然免疫应答机制，2024.01- 2027.12, 260万元。

国家重点研发计划，2023YFC2306100, 病毒与宿主固有免疫互作机制及干预靶点研究，2023.12-2026.11,1200万元。

中国科学院战略性先导科技专项（B类），XDB29010302, 病毒与宿主天然免疫的相互作用机制，2018.06-2023.07,419.19万元。

中国科学院重点部署项目,KJZD-SW-L06,非洲猪瘟病毒免疫应答与疫苗策略研究，2019.01-2021.12, 2070万元。

中国科学院前沿科学重点研究项目，QYZDB-SSW-SMC007,DNA病毒与宿主天然免疫相互作用的分子机制，2016.01-2020.12，250万元。

近五年代表性论文

1. Zhi-Sheng Xu#, Wen-Tian Du#, Su-Yun Wang#, Mo-Yu Wang#, Yi-Ning Yang, Yu-Hui Li, Zhen-Qi Li, Li-Xin Zhao, Yan Yang, Wei-Wei Luo and  Yan-Yi Wang*.LDLR is an entry receptor for Crimean-Congo hemorrhagic fever virus. Cell Research,2024，34(2):140-150.

2. Yu-Hui Li, Jiang-Ling Peng, Zhi-Sheng Xu, Mei-Guang Xiong, Huang-Ning Wu, Su-Yun Wang, Dan Li, Guo-Qiang Zhu, Yong Ran, Yan-Yi Wang*.African Swine Fever Virus Cysteine Protease pS273R Inhibits Type I Interferon Signaling by Mediating STAT2 Degradation. Journal of Virology,2023, 97(3):e0194222.

3. Wei-Wei Luo, Zhen Tong, Pan Cao, Fu-Bing Wang, Ying Liu, Zhou-Qin Zheng, Su-Yun Wang, Shu Li, Yan-Yi Wang*. Transcription-independent regulation of STING activation and innate immune responses by IRF8 in monocytes. Nature Communications,2022,13(1):4822.

4. Zhou-Qin Zheng, Yu-Zhi Fu*, Su-Yun Wang, Zhi-Sheng Xu, Hong-Mei Zou, Yan-Yi Wang*. Herpes simplex virus protein UL56 inhibits cGAS-Mediated DNA sensing to evade antiviral immunity. Cell Insight, 2022, 1:100014.

5. Yong Ran, Dan Li, Mei-Guang Xiong, Hua-Nan Liu, Tao Feng, Zheng-Wang Shi, Yu-Hui Li, Huang-Ning Wu, Su-Yun Wang, Hai-Xue Zheng*, Yan-Yi Wang*. African swine fever virus I267L acts as an important virulence factor by inhibiting RNA polymerase III-RIG-I-mediated innate immunity. PLoS Pathogens, 2022, 18(1): e1010270.

6. Yan Yang#, Su-Yun Wang#,Zhen-Qi Li, Huang-Ning Wu. Mex3B inhibits DC-STAMP mRNA level and osteoclastogenesis. Cell Insight, 2022, 1:100002.

7. Bo-Wei Liao, Hong-Yan Zhang, Wen-Tian Du, Yong Ran, Yan-Yi Wang*, Zhi-Sheng Xu*. FAM177A1 Inhibits IL-1β–Induced Signaling by Impairing TRAF6–Ubc13 Association. Journal of Immunology, 2021, 207 (12) 3090-3097. 

8. Zhou-Qin Zheng#, Su-Yun Wang#, Zhi-Sheng Xu#, Yu-Zhi Fu*, Yan-Yi Wang*. SARS-CoV-2 nucleocapsid protein impairs stress granule formation to promote viral replication. Cell Discovery, 2021,7(1):38. 

9. Wei-Wei Li, Ying Nie, Yan Yang, Yong Ran, Wei-Wei Luo, Mei-Guang Xiong, Su-Yun Wang, Zhi-Sheng Xu*, Yan-Yi Wang*. Ubiquitination of TLR3 by TRIM3 signals its ESCRT mediated trafficking to the endolysosomes for innate antiviral response. PNAS, 2020, 117(38): 23707-23716.

10. Yu-Zhi Fu#*, Su-Yun Wang#, Zhou-Qin Zheng#, Yi Huang, Wei-Wei Li, Zhi-Sheng Xu, Yan-Yi Wang*. SARS-CoV-2 membrane glycoprotein M antagonizes the MAVS-mediated innate antiviral response. Cellular & Molecular Immunology, 2021,18(3): 613-620. 

11. Zhi-Sheng Xu#, Ting Shu#, Liang Kang#, Di Wu #, Xing Zhou#, Bo-Wei Liao, Xiu-Lian Sun, Xi Zhou, Yan-Yi Wang*. Temporal profiling of plasma cytokines, chemokines and growth factors from mild, severe and fatal COVID-19 patients. Signal Transduction and Targeted Therapy, 2020,5(1):100. 

12. Hong-Mei Zou, Zhe-Fu Huang, Yan Yang, Wei-Wei Luo, Su-Yun Wang, Min-Hua Luo, Yu-Zhi Fu*, Yan-Yi Wang*. Human Cytomegalovirus Protein UL94 Targets MITA to Evade Antiviral Immune Response. Journal of Virology, 2020, 93(12): e00022-20. 

13. Mei-Guang Xiong, Zhi-Sheng Xu, Wei-Wei Luo, Yu-Hui Li, Su-Yun Wang, Yan-Yi Wang*, Yong Ran*. RNF152 positively regulates TLR/IL-1R signaling by enhancing signaling MyD88 oligomerization. EMBO Reports, 2020, 21(3): e48860. 

14. Hong-Yan Zhang, Bo-Wei Liao, Zhi-Sheng Xu, Yong Ran, Dong-Peng Wang, Yan Yang, Wei-Wei Luo*, Yan-Yi Wang*. USP44 positively regulates innate immune response to DNA viruses through deubiquitinating MITA. PLoS Pathogens, 2019,16(1): e1008178. 

15. Yong Ran*, Mei-Guang Xiong, Zhi-Sheng Xu, Wei-Wei Luo, Su-Yun Wang, Yan-Yi Wang. YIPF5 Is Essential for Innate Immunity to DNA Virus and Facilitates COPII-Dependent STING Trafficking. Journal of Immunology, 2019, 203(6):1560-1570.

16. Yu-Zhi Fu, Yi Guo, Hong-Mei Zou, Shan Su, Su-Yun Wang, Qing Yang, Min-Hua Luo, Yan-Yi Wang*. Human cytomegalovirus protein UL42 antagonizes cGAS/MITA-mediated innate antiviral response. PLoS Pathogens, 2019,15(5): e1007691.

17. Zhi-Sheng Xu#, Hong-Xia Zhang#, Wei-Wei Li, Yong Ran, Tian-Tian Liu, Mei-Guang Xiong, Qing-Lan Li, Su-Yun Wang, Min Wu, Hong-Bing Shu, Huimin Xia *, Yan-Yi Wang*. FAM64A positively regulates STAT3 activity to promoteTh17 differentiation and colitis-associated carcinogenesis. PNAS, 2019, 116(21):10447-10452.

18. Yu-Zhi Fu, Shan Su, Hong-Mei Zou, Yi Guo, Su-Yun Wang, Shu Li, Min-Hua Luo, Yan-Yi Wang*. Human Cytomegalovirus DNA Polymerase Subunit UL44 Antagonizes Antiviral Immune Responses by Suppressing IRF3- and NF-kappa B-Mediated Transcription. Journal of Virology, 2019, 93(11): e00181-19.