王延轶

研究方向

主要开展病毒与宿主相互作用机制研究，具体包括：（1）鉴定高致病性病毒感染复制所依赖的关键宿主因子并解析其作用机制；（2）利用RNA/DNA病毒、急性/慢性感染病毒、高致病性/低致病性病毒等多种感染模型研究宿主抗病毒天然免疫及病毒免疫逃逸的动态调控机制。

在国际上首次报道了低密度脂蛋白受体（LDLR）是生物安全四级病原克里米亚-刚果出血热病毒（CCHFV）的入侵受体，解决了该病毒受体数十年来一直未被鉴定的难题；发现了高致病性病毒西方马脑炎病毒（WEEV）入侵神经细胞的受体原钙粘蛋白10（PCDH10）；阐释了宿主抗病毒天然免疫应答及时启动、适时终止的重要调控机制；解析了疱疹、新冠等病毒的免疫逃逸策略。

教育及工作经历

2012.03-至今，中国科学院武汉病毒研究所，研究员/学科组长

2010.11-2012.02，武汉大学生命科学学院，副教授

2006.09-2010.10，武汉大学生命科学学院，讲师

2007.09-2010.06，武汉大学生命科学学院，博士

2004.08-2006.06，美国科罗拉多大学医学院免疫学系，硕士

2000.09-2004.06，北京大学生命科学学院，学士

近五年承担项目

国家自然科学基金联合基金项目，克里米亚-刚果出血热病毒（CCHFV）感染复制与宿主天然免疫应答机制，2024.01- 2027.12。

国家重点研发计划，病毒与宿主固有免疫互作机制及干预靶点研究，2023.12-2026.11。

关键宿主细胞器调控重要呼吸道病毒感染与致病机理研究，广州国家实验室专项，2024.04-2028.09。

重要布尼亚病毒感染和出血机制研究，建制化攻关重点项目，2024.06-2027.05。

中国科学院战略性先导科技专项（B类），病毒与宿主天然免疫的相互作用机制，2018.06-2023.07。

近五年代表性论文

1. Yan Yang#, Li-Xin Zhao#, Zhen-Qi Li, Su-Yun Wang, Zhi-Sheng Xu ,Yan-Yi Wang*. PCDH10 is a neuronal receptor for western equine encephalitis virus. Cell Research,2024, 34(11),802–805.

2. Zhi-Sheng Xu#, Wen-Tian Du#, Su-Yun Wang#, Mo-Yu Wang#, Yi-Ning Yang, Yu-Hui Li, Zhen-Qi Li, Li-Xin Zhao, Yan Yang, Wei-Wei Luo and  Yan-Yi Wang*.LDLR is an entry receptor for Crimean-Congo hemorrhagic fever virus. Cell Research,2024，34(2):140-150.

3. Yu-Hui Li, Jiang-Ling Peng, Zhi-Sheng Xu, Mei-Guang Xiong, Huang-Ning Wu, Su-Yun Wang, Dan Li, Guo-Qiang Zhu, Yong Ran, Yan-Yi Wang*.African Swine Fever Virus Cysteine Protease pS273R Inhibits Type I Interferon Signaling by Mediating STAT2 Degradation. Journal of Virology,2023, 97(3):e0194222.

4. Wei-Wei Luo, Zhen Tong, Pan Cao, Fu-Bing Wang, Ying Liu, Zhou-Qin Zheng, Su-Yun Wang, Shu Li, Yan-Yi Wang*. Transcription-independent regulation of STING activation and innate immune responses by IRF8 in monocytes. Nature Communications,2022,13(1):4822.

5. Zhou-Qin Zheng, Yu-Zhi Fu*, Su-Yun Wang, Zhi-Sheng Xu, Hong-Mei Zou, Yan-Yi Wang*. Herpes simplex virus protein UL56 inhibits cGAS-Mediated DNA sensing to evade antiviral immunity. Cell Insight, 2022, 1:100014.

6. Yong Ran, Dan Li, Mei-Guang Xiong, Hua-Nan Liu, Tao Feng, Zheng-Wang Shi, Yu-Hui Li, Huang-Ning Wu, Su-Yun Wang, Hai-Xue Zheng*, Yan-Yi Wang*. African swine fever virus I267L acts as an important virulence factor by inhibiting RNA polymerase III-RIG-I-mediated innate immunity. PLoS Pathogens, 2022, 18(1): e1010270.

7. Yan Yang#, Su-Yun Wang#,Zhen-Qi Li, Huang-Ning Wu. Mex3B inhibits DC-STAMP mRNA level and osteoclastogenesis. Cell Insight, 2022, 1:100002.

8. Bo-Wei Liao, Hong-Yan Zhang, Wen-Tian Du, Yong Ran, Yan-Yi Wang*, Zhi-Sheng Xu*. FAM177A1 Inhibits IL-1β–Induced Signaling by Impairing TRAF6–Ubc13 Association. Journal of Immunology, 2021, 207 (12) 3090-3097. 

9. Zhou-Qin Zheng#, Su-Yun Wang#, Zhi-Sheng Xu#, Yu-Zhi Fu*, Yan-Yi Wang*. SARS-CoV-2 nucleocapsid protein impairs stress granule formation to promote viral replication. Cell Discovery, 2021,7(1):38. 

10. Wei-Wei Li, Ying Nie, Yan Yang, Yong Ran, Wei-Wei Luo, Mei-Guang Xiong, Su-Yun Wang, Zhi-Sheng Xu*, Yan-Yi Wang*. Ubiquitination of TLR3 by TRIM3 signals its ESCRT mediated trafficking to the endolysosomes for innate antiviral response. PNAS, 2020, 117(38): 23707-23716.

11. Yu-Zhi Fu#*, Su-Yun Wang#, Zhou-Qin Zheng#, Yi Huang, Wei-Wei Li, Zhi-Sheng Xu, Yan-Yi Wang*. SARS-CoV-2 membrane glycoprotein M antagonizes the MAVS-mediated innate antiviral response. Cellular & Molecular Immunology, 2021,18(3): 613-620. 

12. Zhi-Sheng Xu#, Ting Shu#, Liang Kang#, Di Wu #, Xing Zhou#, Bo-Wei Liao, Xiu-Lian Sun, Xi Zhou, Yan-Yi Wang*. Temporal profiling of plasma cytokines, chemokines and growth factors from mild, severe and fatal COVID-19 patients. Signal Transduction and Targeted Therapy, 2020,5(1):100. 

13. Hong-Mei Zou, Zhe-Fu Huang, Yan Yang, Wei-Wei Luo, Su-Yun Wang, Min-Hua Luo, Yu-Zhi Fu*, Yan-Yi Wang*. Human Cytomegalovirus Protein UL94 Targets MITA to Evade Antiviral Immune Response. Journal of Virology, 2020, 93(12): e00022-20. 

14. Mei-Guang Xiong, Zhi-Sheng Xu, Wei-Wei Luo, Yu-Hui Li, Su-Yun Wang, Yan-Yi Wang*, Yong Ran*. RNF152 positively regulates TLR/IL-1R signaling by enhancing signaling MyD88 oligomerization. EMBO Reports, 2020, 21(3): e48860.