杨航

研究方向

1.噬菌体来源抗菌药物发现

2.噬菌体与哺乳动物细胞互作

3.噬菌体编辑

教育及工作经历

2021.10-            中国科学院武汉病毒研究所    研究员

2018.04-2019.04    马里兰大学帕克分校          访问学者

2018.01-2021.10    中国科学院武汉病毒研究所    青年研究员

2015.08-2017.12    中国科学院武汉病毒研究所    副研究员

2013.07-2015.08    中国科学院武汉病毒研究所    助理研究员

2010.09-2013.06    中国科学院武汉病毒研究所    微生物学   博士

2007.09-2010.06    华中农业大学                发酵工程    硕士

2003.09-2007.06    武汉轻工大学                生物工程    学士

近五年承担项目

1. 主持国家自然科学基金3项（面上项目2项，国际合作与交流项目1项）；

2. 主持人才项目3项（湖北省杰青、武汉市黄鹤英才科技计划以及中科院青促会项目）；

3. 以研究骨干参与国家自然科学基金、科学院知识创新工程、科技部重点专项等项目多项。

近五年代表性论文

2025

1. Hu F#, Zhang X#, Gong Z#, Wu P, Zhao Q, Zheng Y, Gao H, Chou SH, Li X,   Zhong M, Zhao Z, Shi N, Wei H, He J*, Yang H*. 2025. Domain interactions   in a chimeric dual-domain lysin lead to broad bactericidal activity. J Mol   Biol 437:169373.

2. Li X, Wang Y, Zhong M, Liu   L, Xue H, Chuai X, Wei H, Chiu S*, Yang H*. 2025. From Good to Better:   Comparative Epitope Profiling Facilitates Rational Design of Effective   Multi-Epitope Vaccines Against Viruses. J Med Virol 97:e70366.

2024

1. Zhang L#, Hu F#, Zhao   Z#, Li X, Zhong M, He J, Yao F, Zhang X, Mao Y, Wei H, He J*,   Yang H*. 2024. Dimer-monomer transition defines a hyper-thermostable   peptidoglycan hydrolase mined from bacterial proteome by lysin-derived   antimicrobial peptide-primed screening. Elife 13.

2. Yi Y#*, Yu R#, Xue H,   Jin Z, Zhang M, Bao YO, Wang Z, Wei H, Qiao X, Yang H*. 2024. Chrysin   7-O-beta-D-glucuronide, a dual inhibitor of SARS-CoV-2 3CL(pro) and PL(pro),   for the prevention and treatment of COVID-19. Int J Antimicrob Agents   63:107039.

2023

1.Wu L#,   Zheng A#, Tang Y#, Chai Y#, Chen J, Cheng L,   Hu Y, Qu J, Lei W, Liu WJ, Wu G, Zeng S, Yang H*, Wang Q*, Gao GF*. 2023.   A pan-coronavirus peptide inhibitor prevents SARS-CoV-2 infection in mice by   intranasal delivery. Sci China Life Sci 66:2201-2213.

2.Yi Y#,   Li W#, Liu K#, Xue H#, Yu R, Zhang M, Bao   YO, Lai X, Fan J, Huang Y, Wang J, Shi X, Li J, Wei H, Xiang K, Li L, Zhang   R, Zhao X, Qiao X, Yang H*, Ye M*. 2023. Licorice-saponin A3 is a   broad-spectrum inhibitor for COVID-19 by targeting viral spike and   anti-inflammation. J Pharm Anal 14:115-27.

3.Jia   M, Zhou W, Luo D, Xue H, Hu F, Zhang X, Zhao Z, Zhong M, Li X, He J, Wei H, Yang   H*. 2023. Calcium-binding motif-mediated binding of redundant calcium   offers a chimeolysin enhanced bactericidal activity and extended host range   under physiological conditions. J Antimicrob Chemother   78:1182-1190.

2022

1.Yi Y#, Li J#, Lai X#,   Zhang M#, Kuang Y, Hong W, Wei H, Li T, Zhuang H, Qiao X, Xiang   K*, Yang H*, Ye M*, Natural triterpenoids from licorice potently   inhibit SARS-CoV-2 infection. J Adv Res, 2022, 36:201-210.

2.Muturi E, Hong W, Li J, Yang W, He J, Wei H*, Yang   H*. 2022. Effects of simeprevir on the replication of SARS-CoV-2 in vitro   and in transgenic hACE2 mice. Int J Antimicrob Agents 59:106499.

3.Dai W#, Jochmans D#, Xie   H#, Yang H#, Li J, Su H, Chang D, Wang J, Peng   J, Zhu L, Nian Y, Hilgenfeld R, Jiang H, Chen K, Zhang L*, Xu Y*, Neyts J*,   Liu H*. 2022. Design, Synthesis, and Biological Evaluation of Peptidomimetic   Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2. J   Med Chem 65:2794-2808.

2021

1.Muturi E, Meng F, Liu H, Jiang M, Wei H*, Yang   H*, Comprehensive analysis of G-quadruplexes in ASFV genome reveals   potential antiviral targets by G-quadruplex stabilizers. Front Microbiol,   2021, 12:798431.

2.Li C, Jiang M, Khan FM, Zhao X, Wang G, Zhou W,   Li J, Yu J, Li Y, Wei H*, Yang H*. Intrinsic Antimicrobial Peptide   Facilitates a New Broad-Spectrum Lysin LysP53 to Kill Acinetobacter   baumannii In Vitro and in a Mouse Burn Infection Model. ACS Infect Dis,   2021, 7(12):3336-3344.

3.Yang H, Xu J, Gong   Y, Tang Y, Li W, Zheng Z, Li Y, He J, Wei H*.    Internal cell-penetrating peptide-mediated internalization enables a   chimeric lysin to target intracellular pathogens. Int J Pharm 2021,   599:120449.

4.Khan FM, Gondil VS, Li C, Jiang M, Li J, Yu J,   Wei H*, Yang H*. A novel Acinetobacter baumannii bacteriophage   endolysin LysAB54 with high antibacterial activity against multiple   Gram-negative microbes. Front Cell Infect Microbiol, 2021, 11:637313.

2020

1.Luo D, Huang L, Gondil VS, Zhou W, Yang W, Jia   M, Hu S, He J*, Yang H*, Wei H*.   2020. A Choline-Recognizing Monomeric Lysin, ClyJ-3m, Shows Elevated   Activity against Streptococcus pneumoniae. Antimicrob Agents Chemother 64.

2.Huang L, Luo D, Gondil VS, Gong Y, Jia M, Yan   D, He J, Hu S*, Yang H*, Wei H*.   2020. Construction and characterization of a chimeric lysin ClyV with   improved bactericidal activity against Streptococcus agalactiae in vitro and   in vivo. Appl Microbiol Biotechnol 104:1609-1619.

3.Yang H, Luo D, Etobayeva I, Li X, Gong Y, Wang S, Li   Q, Xu P, Yin W, He J*, Nelson DC*, Wei H*. 2020. Linker Editing of Pneumococcal Lysin ClyJ Conveys Improved   Bactericidal Activity. Antimicrob Agents Chemother 64.