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姓 名：杨航 职称职务：研究员 电子邮箱：yangh@wh.iov.cn |
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研究方向 1.抗微生物耐药与治疗（Antimicrobial Resistance and Therapy） 2.噬菌体药物学（Phage-derived drug discovery） 3.噬菌体药物展示（Phage-mediated drug display） 4.细菌免疫治疗（Immunotherapy strategies against bacterial infection） 教育及工作经历 | |
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2003.09-2007.06 武汉轻工大学生物工程学士 2007.09-2010.06 华中农业大学发酵工程硕士 2010.09-2013.06 中国科学院武汉病毒研究所微生物学博士 2013.07-2015.08 中国科学院武汉病毒研究所助理研究员 2015.08-2017.12 中国科学院武汉病毒研究所副研究员 2018.01-2021.10 中国科学院武汉病毒研究所青年研究员 2021.10- 中国科学院武汉病毒研究所研究员 近五年承担项目 | |
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1.主持国家自然科学基金4项（青年基金1项，面上项目2项，国际合作与交流项目1项）； 2.主持人才项目2项（武汉市黄鹤英才科技计划以及中科院青促会项目）； 3.以研究骨干参与国家自然科学基金、科学院知识创新工程、科技部重点专项等项目多项。 近五年代表性论文 | |
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代表性论文： 2022 1.Yi Y#, Zhang M#, Xue H#, Yu R, Bao YO, Kuang Y, Chai Y, Ma W, Wang J, Shi X, Li W, Hong W, Li J, Muturi E, Wei H, Wlodarz J, Roszak S, Qiao X*, Yang H*, Ye M*. Schaftoside inhibits 3CL(pro) and PL(pro) of SARS-CoV-2 virus and regulates immune response and inflammation of host cells for the treatment of COVID-19. Acta Pharm Sin B 12:4154-4164，2022 2.Dai W#, Jochmans D#, Xie H#, Yang H#, Li J, Su H, Chang D, Wang J, Peng J, Zhu L, Nian Y, Hilgenfeld R, Jiang H, Chen K, Zhang L*, Xu Y*, Neyts J*, Liu H*. Design, synthesis, and biological evaluation of peptidomimetic aldehydes as broad-spectrum inhibitors against enterovirus and SARS-CoV-2. J Med Chem 65:2794-2808, 2022. 3.Muturi E, Hong W, Li J, Yang W, He J, Wei H*, Yang H*. Effects of simeprevir on the replication of SARS-CoV-2 in vitro and in transgenic hACE2 mice. Int J Antimicrob Agents 59:106499，2022. 4.Yi Y#, Li J#, Lai X#, Zhang M#, Kuang Y, Hong W, Wei H, Li T, Zhuang H, Qiao X, Xiang K*, Yang H*, Ye M*, Natural triterpenoids from licorice potently inhibit SARS-CoV-2 infection. J Adv Res 36:201-210, 2022.
2021 1.Muturi E, Meng F, Liu H, Jiang M, Wei H*, Yang H*, Comprehensive analysis of G-quadruplexes in ASFV genome reveals potential antiviral targets by G-quadruplex stabilizers. Front Microbiol, 2021. 2.Hong W, Nyaruaba R, Li X, Liu H, Yang H*, Wei H*, In-situ and real-time monitoring of the interaction between lysins andStaphylococcus aureusbiofilm by surface plasmon resonance. Front Microbiol, 2021. 3.Yang W, Gondil VS, Luo D, He J, Wei H, Yang H*. Optimized silica-binding peptide-mediated delivery of bactericidal lysin efficiently preventsStaphylococcus aureusfrom adhering to device surfaces. Int J Mol Sci, 2021, 22. 4.Li C, Jiang M, Khan FM, Zhao X, Wang G, Zhou W, Li J, Yu J, Li Y, Wei H*, Yang H*. Intrinsic Antimicrobial Peptide Facilitates a New Broad-Spectrum Lysin LysP53 to KillAcinetobacter baumanniiIn Vitro and in a Mouse Burn Infection Model. ACS Infect Dis, 2021. 5.Hong W#, Xiong J#, Nyaruaba R, Li J, Muturi E, Liu H, Yu J, Yang H*, Wei H*. Rapid determination of infectious SARS-CoV-2 in PCR-positive samples by SDS-PMA assisted RT-qPCR. Sci Total Environ, 2021, 797:149085. 6.Li X, Wang S, Nyaruaba R, Liu H, Yang H*, Wei H*. A highly active chimeric lysin with a calcium-enhanced bactericidal activity againstStaphylococcus aureusin vitro and in vivo. Antibiotics (Basel), 2021, 10. 7.Yang H, Xu J, Gong Y, Tang Y, Li W, Zheng Z, Li Y, He J, Wei H*. Internal cell-penetrating peptide-mediated internalization enables a chimeric lysin to target intracellular pathogens. Int J Pharm 2021, 599:120449. 8.Khan FM, Gondil VS, Li C, Jiang M, Li J, Yu J, Wei H*, Yang H*. A novelAcinetobacter baumanniibacteriophage endolysin LysAB54 with high antibacterial activity against multiple Gram-negative microbes. Front Cell Infect Microbiol, 2021, 11:637313. 2020 1.Luo D, Huang L, Gondil VS, Zhou W, Yang W, Jia M, Hu S, He J*, Yang H*, Wei H*. 2020. A Choline-Recognizing Monomeric Lysin, ClyJ-3m, Shows Elevated Activity against Streptococcus pneumoniae. Antimicrob Agents Chemother 64. 2.Huang L, Luo D, Gondil VS, Gong Y, Jia M, Yan D, He J, Hu S*, Yang H*, Wei H*. 2020. Construction and characterization of a chimeric lysin ClyV with improved bactericidal activity against Streptococcus agalactiae in vitro and in vivo. Appl Microbiol Biotechnol 104:1609-1619. 3.Wang Y, Khanal D, Yoon Kyung Chang R, Shang X, Yang H, Britton WJ, Nelson D, Chan HK. 2020. Can bacteriophage endolysins be nebulised for inhalation delivery against Streptococcus pneumoniae? Int J Pharm 2019 1.Yang H, Luo D, Etobayeva I, Li X, Gong Y, Wang S, Li Q, Xu P, Yin W, He J, Nelson DC, Wei H. 2019. Linker editing of pneumococcal lysin ClyJ conveys improved bactericidal activity. Antimicrob Agents Chemother doi:10.1128/AAC.01610-19. 2.Yang H, Gong Y, Zhang H, Etobayeva I, Miernikiewicz P, Luo D, Li X, Zhang X, Dabrowska K, Nelson DC, He J, Wei H. 2019. ClyJ Is a Novel Pneumococcal Chimeric Lysin with a Cysteine- and Histidine-Dependent Amidohydrolase/Peptidase Catalytic Domain. Antimicrob Agents Chemother 63. 2018 1.Yang H, Xu J, Li W, Wang S, Li J, Yu J, Li Y, Wei H. 2018. Staphylococcus aureus virulence attenuation and immune clearance mediated by a phage lysin-derived protein. EMBO J 37. 2.Li W#, Yang H#*, Gong Y, Wang S, Li Y*, Wei H*. 2018. Effects of a Chimeric Lysin against Planktonic and Sessile Enterococcus faecalis Hint at Potential Application in Endodontic Therapy. Viruses 10. 3.Xu J#, Yang H#, Bi Y, Li W, Wei H, Li Y*. 2018. Activity of the Chimeric Lysin ClyR against Common Gram-Positive Oral Microbes and Its Anticaries Efficacy in Rat Models. Viruses 10. 2012-2017 1. Yang H, Zhang H, Wang J, Yu J, Wei H*. 2017. A novel chimeric lysin with robust antibacterial activity against planktonic and biofilm methicillin-resistant Staphylococcus aureus. Sci Rep 7:40182. 2. Yang H#, Bi Y#, Shang X, Wang M, Linden SB, Li Y, Li Y*, Nelson DC*, Wei H*. 2016. Antibiofilm Activities of a Novel Chimeolysin against Streptococcus mutans under Physiological and Cariogenic Conditions. Antimicrob Agents Chemother 60:7436-7443. 3. Yang H#, Wang M#, Yu J, Wei H*. 2015. Antibacterial Activity of a Novel Peptide-Modified Lysin Against Acinetobacter baumannii and Pseudomonas aeruginosa. Front Microbiol 6:1471. 4. Yang H, Wang M, Yu J, Wei H*. 2015. Aspartate inhibits Staphylococcus aureus biofilm formation. FEMS Microbiol Lett 362. 5. Yang H, Linden SB, Wang J, Yu J, Nelson DC*, Wei H*. 2015. A chimeolysin with extended-spectrum streptococcal host range found by an induced lysis-based rapid screening method. Sci Rep 5:17257. 6. Huang Y#, Yang H#, Yu J, Wei H*. 2015. Molecular dissection of phage lysin PlySs2: integrity of the catalytic and cell wall binding domains is essential for its broad lytic activity. Virol Sin 30:45-51. 7.杨航，余军平，危宏平. 2015.裂解酶治疗的研究进展与应用前景.微生物学通报42:178-184. 8. Yang H, Zhang Y, Yu J, Huang Y, Zhang XE, Wei H*. 2014. Novel chimeric lysin with high-level antimicrobial activity against methicillin-resistant Staphylococcus aureus in vitro and in vivo. Antimicrob Agents Chemother 58:536-42. 9. Yang H, Zhang Y, Huang Y, Yu J, Wei H*. 2014. Degradation of methicillin-resistant Staphylococcus aureus biofilms using a chimeric lysin. Biofouling 30:667-74. 10. Yang H, Yu J, Wei H*. 2014. Engineered bacteriophage lysins as novel anti-infectives. Front Microbiol 5:542. 11. Yang H, Wang DB, Dong Q, Zhang Z, Cui Z, Deng J, Yu J, Zhang XE, Wei H*. 2012. Existence of separate domains in lysin PlyG for recognizing Bacillus anthracis spores and vegetative cells. Antimicrob Agents Chemother 56:5031-9. 专利： 1.危宏平，杨航，一种高效肺炎链球菌嵌合裂解酶及其突变体与应用，2018.7.10，专利申请号：201810751086.X；中国科学院武汉病毒研究所； 2.危宏平，杨航，V12CBD蛋白及其编码基因的一种新用途，2017.10.10，专利申请号：201710935099.8 3.危宏平，杨航，洪伟，卢刚，一种广谱新型嵌合裂解酶GBS PlySb及其编码基因和应用，2017.6.5，专利申请号：201710413547.8； 4.危宏平，杨航，洪伟，一种广谱新型嵌合裂解酶GBS V12b及其编码基因和应用，2017.6.5，专利申请号：201710413374.X； 5.危宏平，杨航，余军平，一种自内裂解大肠杆菌的裂解酶及其应用，2015.04.23，专利申请号：201510197003.3；授权日期：2017-10-27； 6.危宏平，杨航，余军平，一种葡萄球菌裂解酶及其应用，2015.05.18，专利号：201510252947.6；授权日期：2018-4-24； 7.危宏平，杨航，王靖，余军平，一种广谱的链球菌裂解酶及其应用，2015.04.13，中国，专利号：201510171835.8；授权日期：2017-11-14； 8.危宏平，胡伟，杨航，余军平，基于金黄色葡萄球菌的生物探针、制备方法及其应用，2014.09.11，专利号：201410462482.2;授权日期：2016-7-6； 9.危宏平，滕铁山，杨航，余军平，一株能够产生细菌素的分散泛菌以及筛选方法与应用，2014.12.15，专利号：201410777726.6;授权日期：2017-10-13； 10.危宏平，杨航，张云，余军平，张先恩，一种杀灭葡萄球菌的裂解酶及其应用，2013.02.01，中国，专利号：201310043837.x 11.危宏平，杨航，王殿冰，张先恩，识别炭疽芽胞杆菌芽孢的多肽序列及其应用，2012.01.06，中国，专利号：201210006227.8. | |
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