彭珂

姓       名：彭珂

职称职务：学科组长，研究员

电子邮箱：pengke@wh.iov.cn

研究方向

1.新发突发病毒（新型冠状病毒，布尼亚病毒）复制及致病机制的研究

2.抗病毒感染药物研发

3.病毒与宿主相互作用的系统性解析

教育及工作经历

2002年 华中农业大学生命科学技术学院 学士

2007年 中国科学院武汉病毒研究所     博士

2012年 荷兰Wageningen University     博士

2012–2016德国海德堡大学(Heidelberg University)医学院 博士后

2016– 至今 中国科学院武汉病毒研究所 学科组长，研究员

近五年承担项目

1.  国家自然科学基金面上项目，2021.01-2024.12，在研，主持

2.  国家自然科学基金面上项目，2018.01-2021.12，在研，主持

3.  中国科学院率先行动，2017.07-2022.12,在研，主持

4.  国家重点研发计划重点专项，2019.01-2022.12，在研，课题负责人

5. 国家重点研发计划重点专项，2022.11-2025.10，在研，课题负责人

6.  国家重点研发计划重点专项，2021.09-2024.08，在研，骨干

7.  中科院战略性先导专项B，2018.07-2023.06，在研，子课题负责人

近五年代表性论文

1.Yujie Fang, Ke Peng*. Regulation of innate immune responses by cell death-associated caspases during virus infection. 289(14):4098-4111. 2022. FEBS Journal.

2. Zhiwei Sui？, Xinhua Dai？, Qingbin Lu？, Yulan Zhang？, Min Huang？, Shufen Li, Tao Peng, Jie Xie, Yongzhuo Zhang, Chunchen Wu, Jianbo Xia, Lianhua Dong, Jiayi Yang, Wenfeng Huang, Siyuan Liu, Ziquan Wang, Ke Li, Qingfang Yang, Xi Zhou, Ying Wu, Wei Liu*, Xiang Fang* and Ke Peng*. Viral dynamics and antibody responses in people with asymptomatic SARS-CoV-2 infection. 2021. Signal Transduction and Targeted Therapy.

3. Shufen Li*#, Meidi Ye#, Yuanqiao Chen, Yulan Zhang, Jiachen Li, Wei Liu, Hao Li* and Ke Peng*. Screening of a Small Molecule Compound Library Identifies Toosendanin as an Inhibitor Against Bunyavirus and SARS-CoV-2. 2021. Frontiers in Pharmacology.

4. Xu-Rui Shen#, Qian Li#, Hui-Ling Li#, Xi Wang, Qi Wang, Xiao-Shuang Zheng, Rong Geng, Yu-Lan Zhang, Bei Li, Ren-Di Jiang, Mei-Qin Liu, Yan Zhu, Wei Zhang, Xing-Lou Yang, Ke Peng*, Peng Zhou* . Antibody-Dependent Enhancement of SARS-CoV-2 Infection of Human Immune Cells: In Vitro Assessment Provides Insight in COVID-19 Pathogenesis. 2021. Viruses. 

5. Shufen Li#, Yulan Zhang#, Zhenqiong Guan#, Huiling Li, Meidi Ye, Xi Chen, Jun Shen, Yiwu Zhou, Zhengli Shi, Peng Zhou*, Peng K *. SARS-CoV-2 triggers inflammatory responses and cell death through caspase-8 activation.2020. Signal Transduction and Targeted Therapy

6. Shufen Li#, Hao Li#, YuLan Zhang, Qi-Lin Xin, Zhen-Qiong Guan, Xi Chen Xiao-Ai Zhang, Xiao-Kun Li, Geng-Fu Xiao, Pierre-Yves Lozach, Jun Cui, Wei Liu * Lei-Ke Zhang* and Peng K*. SFTSV Infection Induces BAK/BAX-Dependent Mitochondrial DNA Release to Trigger NLRP3 Inflammasome Activation. 30(13):4370-4385. 2020. Cell Reports

7. Min Huang, Qing-Bin Lu, Han Zhao, Yulan Zhang, Zhiwei Sui, Liqun Fang, Di Liu, Xiulian Sun, Peng K*, Wei Liu* and Wuxiang Guan*. Temporal antibody responses to SARS-CoV-2 in patients of coronavirus disease 2019. 2020. Cell Discovery

8. Wan W, Zhu S, Li S, Shang W, Zhang R, Li H, Liu W, Xiao G*, Peng K*, Zhang L*. High-Throughput Screening of an FDA-Approved Drug Library Identifies Inhibitors against Arenaviruses and SARS-CoV-2. 2020. ACS Infectious Diseases.

9. Lei-Ke Zhang#, Yuan Sun#, Haolong Zeng#, Qingxing Wang#, Xiaming Jiang, Wei-Juan Shang, Yan Wu, Shufen Li, Yu-Lan Zhang, Zhao-Nian Hao, Hongbo Chen, Runming Jin, Wei Liu, Hao Li*, Ke Peng* and Gengfu Xiao*. Calcium channel blocker amlodipine besylate therapy is associated with reduced case fatality rate of COVID-19 patients with hypertension. 2020.Cell Discovery

10. Hao Li ？, Lei-Ke Zhang ？, Shufen Li, Shao-Fei Zhang, Wei-Wei Wan, Yu-Lan Zhang, Qi-Lin Xin, Ke Dai, Yuan-Yuan Hu, Zhi-Bo Wang, Xiang-Tao Zhu, Yu-Jie Fang, Ning Cui, Pan-He Zhang, Chun Yuan, Qing-Bin Lu, Jie-Ying Bai, Fei Deng, Geng-Fu Xiao*, Wei Liu* and Ke Peng*. Calcium channel blockers reduce severe fever with thrombocytopenia syndrome virus related fatality. 29(9):739-753. 2019. Cell Research

11. Bejarano DA#, Peng K#*, Laketa V, B？rner K, Jost KL, Lucic B, Glass B, Lusic M, M ller B, Kr？usslich HG*. HIV-1 nuclear import in macrophages is regulated by CPSF6-capsid interactions at the nuclear pore complex. 8. pii: e41800.2019. eLIFE

12. Li S, Zhu X, Guan Z, Huang W, Zhang Y, Kortekaas J, Lozach PY, Peng K*. NSs filament formation is important but not sufficient for RVFV Virulence In Vivo. 11(9). pii: E834.2019. Viruses

13. Novikova M#, Zhang Y#, Freed EO*, Peng K*. Multiple Roles of HIV-1 Capsid during the Virus Replication Cycle. 34(2):119-134. 2019. Virologica Sinica