沈姝

研究方向

1.发现、鉴定和分离（蜱传）新病毒

2.蜱传病毒潜在感染致病风险调查

3.病毒感染诱导血小板应答及出血的机制研究

4.蜱携带和传播病毒的机理与防治手段

教育及工作经历

2021.10-至今       中国科学院武汉病毒研究所   青年研究员

2018.11-2021.09    中国科学院武汉病毒研究所   副研究员

2012.08-2018.10   中国科学院武汉病毒研究所   助理研究员

2006.09-2012.07   中国科学院武汉病毒研究所   微生物学     博士

2001.09-2005.07   武汉大学生命科学院         生物科学     学士

近五年承担项目

国家自然科学基金指南引导类原创探索计划项目、国家自然科学基金面上项目、国家重点研发计划生物安全专项、中国科学院国际伙伴计划未来伙伴网络专项、中国科学院战略生物资源能力建设项目等。

近五年代表性论文

1. Shen S*, Zhang J*, Fang Y*, Lu S, Wu J, Zheng X#, Deng F#. SARS-CoV-2 interacts with platelets and megakaryocytes via ACE2-independent mechanism. J Hematol Oncol. 2021 Apr 29;14(1):72. 

2. Fu D*, Zhang G*, Wang Y*, Zhang Z*, Hu H*, Shen S*, Wu J, Li B, Li X, Fang Y, Liu J, Wang Q, Zhou Y, Wang W, Li Y, Lu Z, Wang X, Nie C, Tian Y, Chen D, Wang Y, Zhou X, Wang Q, Yu F, Zhang C, Deng C, Zhou L, Guan G, Shao N, Lou Z#, Deng F#, Zhang H#, Chen X#, Wang M#, Liu L#, Rao Z#, Guo Y#. Structural basis for SARS-CoV-2 neutralizing antibodies with novel binding epitopes. PLoS Biol. 2021 May 7;19(5):e3001209. 

3. Guo Y*, Huang L*, Zhang G*, Yao Y*, Zhou H*, Shen S*, Shen B, Li B, Li X, Zhang Q, Chen M, Chen D, Wu J, Fu D, Zeng X, Feng M, Pi C, Wang Y, Zhou X, Lu M, Li Y, Fang Y, Lu YY, Hu X, Wang S, Zhang W, Gao G, Adrian F, Wang Q, Yu F, Peng Y, Gabibov AG, Min J, Wang Y, Huang H, Stepanov A, Zhang W, Cai Y, Liu J, Yuan Z, Zhang C, Lou Z#, Deng F#, Zhang H#, Shan C#, Schweizer L#, Sun K#, Rao Z#. A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes. Nat Commun. 2021 May 11;12(1):2623. 

4. Zhang Y*, Hu B*, Agwanda B*, Fang Y, Wang J, Kuria S, Yang J, Masika M, Tang S, Lichoti J, Fan Z, Shi Z, Ommeh S#, Wang H#, Deng F#, Shen S#. Viromes and surveys of RNA viruses in camel-derived ticks revealing transmission patterns of novel tick-borne viral pathogens in Kenya. Emerg Microbes Infect. 2021 Dec;10(1):1975-1987. 

5. Shen S, Zhang Y, Yin Z, Zhu Q, Zhang J, Wang T, Fang Y, Wu X, Bai Y, Dai S, Liu X, Jin J, Tang S, Liu J, Wang M, Guo Y, Deng F. Antiviral activity and mechanism of the antifungal drug, anidulafungin, suggesting its potential to promote treatment of viral diseases. BMC Med. 2022 Oct 21;20(1):359. 

6. Wen Q*, Yin X*, Moming A, Liu G, Jiang B, Wang J, Fan Z, Sajjad W, Ge Y, Kang S#, Shen S#, Deng F#. Viral communities locked in high elevation permafrost up to 100 m in depth on the Tibetan Plateau. Sci Total Environ. 2024 Jul 1;932:172829. doi: 10.1016/j.scitotenv.2024.172829. Epub 2024 Apr 29. PMID: 38692332.

7. Yang P*, Wu X*, Shang H*, Sun Z, Wang Z, Song Z, Yuan H, Deng F, Shen S#, Guo Y#, Zhang N#. Molecular mechanism and structure-guided humanization of a broadly neutralizing antibody against SFTSV. PLoS Pathog. 2024 Sep 25;20(9):e1012550. 

8. Liang B*, Xu L*, Li M, Wang H, Lu S, Fan L, Wang T, Li J, Zhu B, Wang J, Wang B, Peng C, Shen S#, Zheng X#. The Association Between Elevated Myocardial Injury-Related Biomarker (TnI) and Increased Mortality in Patients With Severe Fever With Thrombocytopenia Syndrome. Crit Care Med. 2024 Oct 1;52(10):1509-1519. 

9. Fang Y*, Shen S*, Zhang J, Xu L, Wang T, Fan L, Zhu Q, Xiao J, Wu X, Jin J, Wu Q, Zhang Y, Tang S, Zheng X#, Deng F#. Thrombocytopenia in Severe Fever with Thrombocytopenia Syndrome Due to Platelets With Altered Function Undergoing Cell Death Pathways. J Infect Dis. 2025 Feb 4;231(1):e183-e194. 

10. Zhang J*, Fang Y*, Lin C, Wu X, Yue C, Deng F#, Shen S#. Elevated interferon-induced transmembrane protein 3 in platelets and megakaryocytes suppresses Crimean-Congo hemorrhagic fever viral infection by interacting with glycoprotein Gc. Virol Sin. 2025 Jun;40(3):361-373.