胡葭

姓    名：胡葭

职称职务：副研究员

电子邮箱：hujia@wh.iov.cn

研究方向

1.病原微生物致病机制

2.新发/再发病毒细胞过程调控

教育及工作经历

2002-09至2006-06，华中农业大学，生命科学与技术人才基地，本科；

2006-09至2009-06，华中农业大学，作物生物技术，硕士；

2009-08至2013-08，美国怀俄明大学，分子细胞生物学，博士；

2013-10至2015-05，美国德州大学医学院,微生物与免疫系,博士后；

2015-10至今,中国科学院武汉病毒研究所,微生物技术及应用学科组,副研究员。

近五年承担项目

1、科学科技部，国家重点研发计划“政府间国际科技创新合作/港澳台科技创新合作”重点专项，2018YFE0121900，基于杆状病毒的夜蛾科和其它鳞翅目害虫生物防治技术的开发，2020-01至2021-12，结题，主持；

2、国家自然科学基金委员会，青年科学基金项目，31600112，c-di-AMP信号通路在炭疽杆菌致病机制中的功能研究，2017-01至2019-12，结题，主持；

3、2019-nCoV病毒的环境影响因素及风险防控策略，工程院项目，2020.2-2021.2，参加；

4、空气和固体表面传播新型冠状病毒的机制研究，国家自然科学基金，2020.4-2020.12，参加

近五年代表性论文

1.    Hu J#, Min YQ#, Sun XL. 2022. Cis-regulatory disrupts autorepression: a potential escape-resistant anti-viral therapy. Signal Transduction Target Therapy. 7(1): 338.

2.     Hu J#, Lei CF#, Chen Z#, Liu WH#, Hu XJ, Pei RJ, Su ZY, Deng F, Huang Y, Sun XL, Cao JJ, Guan WX. 2020. Distribution of Airborne SARS-CoV-2 and possible aerosol transmission in Wuhan hospitals, China. National Science Review, nwaa250, https://doi.org/10.1093/nsr/nwaa250.

3.     Hu J, Zhang GB, Liang LQ, Lei CF, Sun XL. 2020. Increased excess intracellular cyclic di-AMP levels impair growth and virulence of Bacillus anthracis. Journal of bacteriology. 202(9):e00653-19.

4.     Hu J; Ross N. B; Cieza J. R; Torres G. Alfredo*; Finding Regulators Associated with the Expression of the Long Polar Fimbriae in Enteropathogenic Escherichia coli, Journal of Bacteriology, 2015, 197(23): 3658~3665 

5.     Wang, J; Yang, J; Lei, CF; Sun, XL#; Hu, J#. 2022. Phosphorylation of the Autographa californica multiple nucleopolyhedrovirus polyhedron envelope protein plays an important role in the formation of the occlusion body envelope. Journal of general virology. 103(6).

6.     Yang, J; Wang, J; Peng, XW; Lei, CF; Sun, XL#; Hu, J#. 2021. Heat shock protein 70, glutamate dehydrogenase, and angiotensin-converting enzyme of Bombyx mori mediate the cell attachment of Cypovirus 1. Journal of general virology. 102(12).

7.     Chen, XG; Yang, J; Yang, XQ; Lei, CF; Sun, XL#; Hu, J#. 2021. A conserved phenylalanine residue of Autographa Californica Multiple Nucleopolyhedrovirus AC75 protein is required for occlusion body formation. Frontiers in Microciology.12:663506.

8.     Chen, XG; Yang, XQ; Lei, CF; Qin, FJ; Sun, XL#; Hu, J#.2020 Autographa californica Multiple Nucleopolyhedrovirus orf13 is Required for Efficient Nuclear Egress of Nucleocapsids. Virologica Sinica. Accepted.

9.     Qin FJ, Xu CR, Hu J, Lei CF, Zheng ZH, Peng K, Wang HZ, Sun XL. 2019. Dissecting the cell entry pathway of baculovirus by single particle tracking and quantitative electron microscopic analysis. Journal of Virology. 93(8): e00033-19.

10.  Xu CR, Wang J, Yang J, Lei CF, Hu J, Sun XL. 2019. NSP2 forms viroplasms during Dendrolimus punctatus cypovirus infection. Virology, 533, 68–76.

11.  Lei CF, Yang SL, Lei WX, Nyamwasa I, Hu J, Sun XL. 2019. Displaying enhancing factors on the surface of occlusion bodies improves the insecticidal efficacy of a baculovirus. Pest Management Science. 76: 1363–1370.