刘雅兰

研究方向

1、HIV-1感染的防治策略研究

2、HSV-2与宿主相互作用机制及HSV-2/HIV-1的共感染及抑制

3、自复制RNA疫苗平台

教育及工作经历

2010年-至今，中国科学院武汉病毒研究所，先后任助理研究员，副研究员

2005-2010年，中国科学院武汉病毒研究所，理学博士

2003年，湖北大学生命科学学院，理学学士

近五年承担项目

1.主持国家自然科学基金面上项目2项

2.作为任务负责人参与国家重点研发计划1项

3.参与艾滋病和病毒性肝炎等重大传染病防治科技重大专项1项

4．主持多项合作研发及横向项目

近五年代表性论文

1. Fengfeng Ni, Kai Hu, Miaomiao Li, Mengshi Yang,   Yingying Xiao, Ming Fu, Zhiyuan Zhu, Yalan Liu*, Qinxue Hu*.   Tat-dependent conditionally replicating adenoviruses expressing diphtheria   toxin A for specifically killing HIV-1-infected cells. Mol Ther. 2024   Jul 3;32(7):2316-2327.

2. Linjing Zhu#, Bilian Huang#, Xiangyao Wang#, Fengfeng Ni#, Mingjun Ao#, Ruoke Wang, Bin Zheng, Chen Chen, Jing Xue, Lin   Zhu, Chenbo Yang, Lingen Shi, Shengya Geng, Jiaqian Hu, Mengshi Yang, Doudou   Zhang, Ping Yang, Miaomiao Li, Yuncheng Li, Qinxue Hu, Sheng Ye, Peng Zheng,   Hongxia Wei, Zhiwei Wu*, Linqi Zhang*, Yaxin Wang*, Yalan Liu*,   Xilin Wu*. Highly potent and broadly neutralizing anti-CD4 trimeric   nanobodies inhibit HIV-1 infection by inducing CD4 conformational alteration.   Nat Commun. 2024 Aug 13;15(1):6961.

3. Yalan Liu*, Zhiyuan Zhu, Yuncheng Li, Mengshi Yang, Qinxue Hu*. Migrasomes released   by HSV-2-infected cells serve as a conveyance for virus spread. Virol Sin.   2023 Jun 7;S1995-820X(23)00061-5.

4. Chuntian Li, Mudan Zhang, Xinmeng Guan, Huimin   Hu, Ming Fu, Yalan Liu*, Qinxue Hu*. Herpes Simplex Virus Type   2 Glycoprotein D Inhibits NF-κB Activation by Interacting with p65. J   Immunol. 2021 Jun 15;206(12):2852-2861.

5. Xilin Wu, Lin Cheng, Ming Fu, Bilian Huang,   Linjing Zhu, Shijie Xu, Haixia Shi, Doudou Zhang, Huanyun Yuan, Waqas Nawaz,   Ping Yang, Qinxue Hu, Yalan Liu*, Zhiwei Wu*. A potent   bispecific nanobody protects hACE2 mice against SARS-CoV-2 infection via   intranasal administration. Cell Rep. 2021 Oct 6;37(3):109869.

6. Xilin Wu#, Yaxing Wang#, Lin Cheng#, Ni   Fengfeng#, Linjing Zhu#, Sen Ma, Bilian Huang, Mengmeng Ji, Huimin Hu,   Yuncheng Li, Shijie Xu, Haixia Shi, Doudou Zhang, Linshuo Liu, Waqas Nawaz,   Qinxue Hu, Sheng Ye*, Yalan Liu*, Zhiwei Wu*. Short-term   instantaneous prophylaxis and efficient treatment against SARS-CoV-2 in hACE2   mice conferred by an intranasal nanobody (Nb22). Front Immunol. 2022   Mar 17;13:865401.