宁云佳

研究方向

1.病毒与宿主的相互作用及感染、致病机理

2. 抗病毒干预靶点及靶向性抗病毒药物或疫苗策略

3. 病毒载体及实验评测模型研发

教育及工作经历

2023/10 –至今中国科学院武汉病毒研究所 研究员

2021/08– 2023/09中国科学院武汉病毒研究所 青年研究员

2017/09 – 2021/08  中国科学院武汉病毒研究所 副研究员

2015/07 – 2017/08  中国科学院武汉病毒研究所 助理研究员

2008/09 – 2015/06  中国科学院大学/中国科学院武汉病毒研究所 微生物学 博士

2004/09 – 2008/06  青岛科技大学 化学工程 学士

近五年承担项目

近五年主持国家自然科学基金面上项目（2项）、国家自然科学基金青年基金项目、中国科学院青年创新促进会人才项目、湖北省自然科学基金项目等，作为项目骨干等角色承担国家重点研发计划（3项）、国家自然科学基金中俄国际合作项目、国家自然科学基金创新群体项目、研究所“一四五”规划项目、青年“突击队”项目、院地合作及企业委托课题等。

近五年代表性论文

1. Mo Q, Xu Z, Deng F, Wang H*, Ning YJ*. Host restriction of emerging high-pathogenic bunyaviruses via MOV10 by targeting viral nucleoprotein and blocking ribonucleoprotein assembly. PLoS Pathog. 2020 Dec 7; 16(12): e1009129. doi: 10.1371/journal.ppat.1009129. Epub ahead of print. PMID: 33284835. (Top Journal) *通讯作者

2. Min YQ, Shi C, Yao T, Feng K, Mo Q, Deng F*, Wang H*, Ning YJ*. The Nonstructural Protein of Guertu Virus Disrupts Host Defenses by Blocking Antiviral Interferon Induction and Action. ACS Infect Dis. 2020 May 8;6(5):857-870. doi: 10.1021/acsinfecdis.9b00492. Epub 2020 Mar 20. PMID: 32167734. (Top 10%) *通讯作者

3. Min YQ, Ning YJ*, Wang H, Deng F*. A RIG-I-like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination. J Biol Chem. 2020 Jul 10; 295(28):9691-9711. doi: 10.1074/ jbc.RA120.013973. (Nature Index; Top Journal) *通讯作者

4. Ren F, Zhou M, Deng F, Wang H*, Ning YJ*. Combinatorial Minigenome Systems for Emerging Banyangviruses Reveal Viral Reassortment Potential and Importance of a Protruding Nucleotide in Genome "Panhandle" for Promoter Activity and Reassortment. Front Microbiol. 2020 Apr 8; 11:599. doi: 10.3389/fmicb.2020.00599. *通讯作者

5. Min YQ#, Mo Q#, Wang J, Deng F, Wang H and Ning YJ*. SARS-CoV-2 nsp1: Bioinformatics, Potential Structural and Functional Features, and Implications for Drug/Vaccine Designs. Front Microbiol. 2020 Sep; 11:587317. doi: 10.3389/ fmicb.2020.587317 *通讯作者

6. Ning YJ, Mo Q, Feng K, Min YQ, Li M, Hou D, Peng C, Zheng X, Deng F, Hu Z, Wang H*. Interferon-γ-Directed Inhibition of a Novel High-Pathogenic Phlebovirus and Viral Antagonism of the Antiviral Signaling by Targeting STAT1. Front Immunol. 2019 May 28; 10:1182. doi: 10.3389/fimmu.2019.01182.

7. Feng K, Deng F, Hu Z, Wang H, Ning YJ*. Heartland virus antagonizes type I and III interferon antiviral signaling by inhibiting phosphorylation and nuclear translocation of STAT2 and STAT1.   J Biol Chem. 2019 Jun 14; 294(24):9503-9517. doi: 10.1074/jbc.RA118.006563. (Nature Index; Top Journal) *通讯作者

8. Ning YJ#, Kang Z#, Xing J, Min YQ, Liu D, Feng K, Wang M, Deng F, Zhou Y, Hu Z, Wang H*. Ebola virus mucin-like glycoprotein (Emuc) induces remarkable acute inflammation and tissue injury: evidence for Emuc pathogenicity in vivo. Protein Cell. 2018 Apr; 9(4):389-393. doi: 10.1007/s13238-017-0471-x. (Top Journal)

9. Ning YJ, Deng F, Hu Z, Wang H*. The roles of ebolavirus glycoproteins in viral pathogenesis. Virol Sin. 2017 Feb;32(1):3-15. doi: 10.1007/s12250-016-3850-1. PMID: 27853993; PMCID: PMC6791933.

10. Ning YJ#, Feng K#, Min YQ, Deng F, Hu Z, Wang H*. Heartland virus NSs protein disrupts host defenses by blocking the TBK1 kinase-IRF3 transcription factor interaction and signaling required for interferon induction. J Biol Chem. 2017 Oct 6; 292(40):16722-16733. doi: 10.1074/jbc.M117.805127. Epub 2017 Aug 28. PMID: 28848048; PMCID: PMC5633133. (Nature Index; Top Journal)

11. Ning YJ, Wang M, Deng M, Shen S, Liu W, Cao WC, Deng F, Wang YY, Hu Z*, Wang H*. Viral suppression of innate immunity via spatial isolation of TBK1/IKKε from mitochondrial antiviral platform. J Mol Cell Biol. 2014 Aug; 6(4):324-37. doi:10.1093/jmcb/mju015. PMID: 24706939; PMCID: PMC7107466. (IF2013=8.432; Top Journal)

12. Ning YJ, Feng K, Min YQ, Cao WC, Wang M, Deng F, Hu Z, Wang H*. Disruption of type I interferon signaling by the nonstructural protein of severe fever with thrombocytopenia syndrome virus via the hijacking of STAT2 and STAT1 into inclusion bodies. J Virol. 2015 Apr;89(8):4227-36. doi: 10.1128/JVI.00154-15. Epub 2015 Jan 28. PMID: 25631085; PMCID: PMC4442386. (Top Journal)

13. Du R, Wang L, Xu H, Wang Z, Zhang T, Wang M, Ning Y, Deng F, Hu Z, Wang H, Li Y*. A novel glycoprotein D-specific monoclonal antibody neutralizes herpes simplex virus. Antiviral Res. 2017 Nov; 147:131-141. doi:10.1016/j.antiviral.2017.10.013. (Top 20%)

14. Hu L, Li Y, Ning YJ, Deng F, Vlak JM, Hu Z, Wang H*, Wang M*. The Major Hurdle for Effective Baculovirus Transduction into Mammalian Cells Is Passing Early Endosomes. J Virol. 2019 Jul 17; 93(15): e00709-19. doi: 10.1128/JVI.00709-19. (Top Journal)

15. Dai S, Deng F*, Wang H*, Ning Y*. Crimean-Congo Hemorrhagic Fever Virus: Current Advances and Future Prospects of Antiviral Strategies. Viruses. 2021 Jun 22; 13(7):1195. doi: 10.3390/v13071195. PMID: 34206476; PMCID: PMC8310003. *通讯作者

16. Wang H, Zhang Z, Zhou J, Han S, Kang Z, Chuang H, Fan H, Zhao H, Wang L, Ning Y, Sarapultsev A, Li WX, Li J, Lin Z, Luo S, Xiong N, Hu D. Next-Generation Sequencing and Proteomics of Cerebrospinal Fluid From COVID-19 Patients With Neurological Manifestations. Front Immunol. 2021 Dec 9; 12:782731. doi: 10.3389/fimmu.2021.782731. PMID: 34956212; PMCID: PMC8695435.

17. Min YQ#, Huang M#, Sun X, Deng F, Wang H, Ning YJ*. Immune evasion of SARS-CoV-2 from interferon antiviral system. Comput Struct Biotechnol J. 2021; 19:4217-4225. doi: 10.1016/j.csbj.2021.07.023. Epub 2021 Jul 26. PMID: 34336145; PMCID: PMC8310780. *通讯作者

18. Ren F, Shen S, Wang Q, Wei G, Huang C*, Wang H*, Ning YJ*, Zhang DY*, Deng F*. Recent Advances in Bunyavirus Reverse Genetics Research: Systems Development, Applications, and Future Perspectives. Front Microbiol. 2021 Dec 7; 12:771934. doi: 10.3389/fmicb.2021.771934. PMID: 34950119; PMCID: PMC8689132. *通讯作者

19. Feng K#, Min YQ#, Sun X, Deng F, Li P*, Wang H*, Ning YJ*. Interactome profiling reveals interaction of SARS-CoV-2 NSP13 with host factor STAT1 to suppress interferon signaling. J Mol Cell Biol. 2021 Dec 30; 13(10):760-762. doi: 10.1093/jmcb/mjab068. PMID: 34687317; PMCID: PMC8574307.  *通讯作者

20. Ren F, Shen S, Ning YJ, Wang Q, Dai S, Shi J, Zhou M, Wang H, Huang C, Zhang DY, Deng F. Non-structural Proteins of Severe Fever With Thrombocytopenia Syndrome Virus Suppress RNA Synthesis in a Transcriptionally Active cDNA-Derived Viral RNA Synthesis System. Front Microbiol. 2021 Aug 16; 12:709517. doi: 10.3389/fmicb.2021.709517. PMID: 34484148; PMCID: PMC8415556.

21. Sun J#, Min YQ#, Li Y, Sun X, Deng F, Wang H*, Ning YJ*. Animal Model of Severe Fever With Thrombocytopenia Syndrome Virus Infection. Front Microbiol. 2022 Jan 11; 12:797189. doi: 10.3389/fmicb.2021.797189. PMID: 35087498; PMCID: PMC8787146. *通讯作者

22. Ni L, Li Y, Wu K, Deng F, Wang H*, Ning YJ*. Antitumor efficacy of CRISPR/Cas9-engineered ICP6 mutant herpes simplex viruses in a mouse xenograft model for lung adenocarcinoma. J Med Virol. 2022 Dec; 94(12):6000-6015. doi: 10.1002/jmv.28069. Epub 2022 Sep 1. PMID: 35965331. *通讯作者

23. Mo Q#, Feng K#, Dai S, Wu Q, Zhang Z, Ali A, Deng F*, Wang H*, Ning YJ*. Transcriptome profiling highlights regulated biological processes and type III interferon antiviral responses upon Crimean-Congo hemorrhagic fever virus infection. Virol Sin. 2022 Sep 5: S1995-820X (22)00150-X. doi: 10.1016/j.virs.2022.09.002. Epub ahead of print. PMID: 36075566.  *通讯作者

24. Feng K, Zhang H, Jiang Z, Zhou M, Min YQ, Deng F, Li P*, Wang H*, Ning YJ*. SFTS bunyavirus NSs protein sequestrates mTOR into inclusion bodies and deregulates mTOR-ULK1 signaling, provoking pro-viral autophagy. J Med Virol. 2022 Dec. doi: 10.1002/jmv.28371.  *通讯作者

25. Chang M, Min Y-Q, Xu Z, Deng F, Wang H*, Ning Y-J*. Host factor MxA restricts Dabie bandavirus infection by targeting the viral NP protein to inhibit NP-RdRp interaction and ribonucleoprotein activity. J Virol. 2023 Dec 6: e0156823. doi: 10.1128/jvi.01568-23. Epub ahead of print. PMID: 38054738. 通讯作者

26. Dai S#, Min YQ#, Li Q, Feng K, Jiang Z, Wang Z, Zhang C, Ren F, Fang Y, Zhang J, Zhu Q, Wang M, Wang H*, Deng F*, Ning YJ*. Interactome profiling of Crimean-Congo hemorrhagic fever virus glycoproteins. Nat Commun. 2023 Nov 14;14(1):7365. doi: 10.1038/s41467-023-43206-1. PMID: 37963884; PMCID: PMC10646030. 通讯作者

27. Hu LF*, Ning YJ*, Li JB*. Editorial: Severe fever with thrombocytopenia syndrome. Front Microbiol. 2023 Sep 5; 14: 1281600. doi: 10.3389/fmicb.2023.1281600. PMID: 37736093; PMCID: PMC10509281. 通讯作者

28. Min YQ, Huang M, Feng K, Jia Y, Sun X*, Ning YJ*. A New Cellular Interactome of SARS-CoV-2 Nucleocapsid Protein and Its Biological Implications. Mol Cell Proteomics. 2023 Jul; 22(7): 100579. doi: 10.1016/j.mcpro.2023.100579. Epub 2023 May 20. PMID: 37211047; PMCID: PMC10198743. 通讯作者

29. Feng K, Zhang HJ, Min YQ, Zhou M, Deng F, Wang HL*, Li PQ*, Ning YJ*. SARS-CoV-2 NSP13 interacts with host IRF3, blocking antiviral immune responses. J Med Virol. 2023 Jun; 95(6): e28881. doi: 10.1002/jmv.28881. 通讯作者

30. Mo Q, Feng K, Dai S, Wu Q, Zhang Z, Ali A, Deng F*, Wang H*, Ning YJ*. Transcriptome profiling highlights regulated biological processes and type III interferon antiviral responses upon Crimean-Congo hemorrhagic fever virus infection. Virol Sin. 2023 Feb; 38(1): 34-46. doi: 10.1016/j.virs.2022.09.002. Epub 2022 Sep 6. PMID: 36075566; PMCID: PMC10006212. 通讯作者